IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population
Zhang, YB; Yu, X; Yuan, YB; Ling, YS; Ruan, Y; Si, TM; Lu, TL; Wu, SP; Gong, XH; Zhu, ZJ; Yang, JZ; Wang, F; Zhang, D
关键词schizophrenia FZD3 single nucleotidepolymorphisms (SNPs) haplotype analysis case-control based association study
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2004-08-15
DOI10.1002/ajmg.b.30076
129B期:1页:16-19
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]WORKSHOP REPORT ; LOCUS ; DISEQUILIBRIUM ; SPECIFICATION ; LINKAGE ; DISEASE ; BRAIN
英文摘要

Frizzled 3 (FZD3) gene is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies. The FZD3 is a transmembrane receptor required for Wnt signal transduction cascades that have been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Previous work has showed a strong association between FZD3 locus and schizophrenia in family-based study. To confirm this issue further, we investigated a genetic association between four single nucleotide polymorphisms (SNPs) located in the FZD3 gene and schizophrenia by case-control study using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) in the Chinese Han population. Our studies showed the SNPs rs2323019 and rs880481 have significant differences in both genotype and allele frequencies between control subjects and schizophrenic patients (rs2323019: Allele A>G, chi(2) = 6.7277, df = 1, P = 0.0095; Genotype, chi(2) = 10.6583, df = 2, P = 0.0049; rs880481: Allele A > G, chi(2) = 10.3945, df = 1, P = 0.0013; Genotype, chi(2) = 16.8049, df = 2, P = 0.0002). In addition, we constructed three-locus haplotypes to test their association with schizophrenia. The globe chi-squared test for haplotype analysis showed a significant association (chi(2) = 66.38, df = 7, P < 0.000001). These results suggested that the FZD3 gene might be involved in the predisposition to schizophrenia. (C) 2004 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000222975700004
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59128
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, YB,Yu, X,Yuan, YB,et al. Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2004,129B(1):16-19.
APA Zhang, YB.,Yu, X.,Yuan, YB.,Ling, YS.,Ruan, Y.,...&Zhang, D.(2004).Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,129B(1),16-19.
MLA Zhang, YB,et al."Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 129B.1(2004):16-19.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, YB]的文章
[Yu, X]的文章
[Yuan, YB]的文章
百度学术
百度学术中相似的文章
[Zhang, YB]的文章
[Yu, X]的文章
[Yuan, YB]的文章
必应学术
必应学术中相似的文章
[Zhang, YB]的文章
[Yu, X]的文章
[Yuan, YB]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。