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学科主题: 精神卫生
题名:
Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population
作者: Zhang, YB; Yu, X; Yuan, YB; Ling, YS; Ruan, Y; Si, TM; Lu, TL; Wu, SP; Gong, XH; Zhu, ZJ; Yang, JZ; Wang, F; Zhang, D
关键词: schizophrenia ; FZD3 ; single nucleotidepolymorphisms (SNPs) ; haplotype analysis ; case-control based association study
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2004-08-15
DOI: 10.1002/ajmg.b.30076
卷: 129B, 期:1, 页:16-19
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: WORKSHOP REPORT ; LOCUS ; DISEQUILIBRIUM ; SPECIFICATION ; LINKAGE ; DISEASE ; BRAIN
英文摘要:

Frizzled 3 (FZD3) gene is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies. The FZD3 is a transmembrane receptor required for Wnt signal transduction cascades that have been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Previous work has showed a strong association between FZD3 locus and schizophrenia in family-based study. To confirm this issue further, we investigated a genetic association between four single nucleotide polymorphisms (SNPs) located in the FZD3 gene and schizophrenia by case-control study using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) in the Chinese Han population. Our studies showed the SNPs rs2323019 and rs880481 have significant differences in both genotype and allele frequencies between control subjects and schizophrenic patients (rs2323019: Allele A>G, chi(2) = 6.7277, df = 1, P = 0.0095; Genotype, chi(2) = 10.6583, df = 2, P = 0.0049; rs880481: Allele A > G, chi(2) = 10.3945, df = 1, P = 0.0013; Genotype, chi(2) = 16.8049, df = 2, P = 0.0002). In addition, we constructed three-locus haplotypes to test their association with schizophrenia. The globe chi-squared test for haplotype analysis showed a significant association (chi(2) = 66.38, df = 7, P < 0.000001). These results suggested that the FZD3 gene might be involved in the predisposition to schizophrenia. (C) 2004 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000222975700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59128
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, YB,Yu, X,Yuan, YB,et al. Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2004,129B(1):16-19.
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