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Studies on the cyclosporin A loaded stearic acid nanoparticles
Zhang, QN; Yie, GQ; Li, Y; Yang, QS; Nagai, YT
关键词drug carrier stearic acid nanoparticles cyclosporin A relative bioavailability
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2000-05-10
200期:2页:153-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SOLID LIPID NANOPARTICLES ; STABILITY ; SLN(TM) ; SLN
英文摘要

Stearic acid nanoparticles were prepared in this study by melt-homogenization to investigate the possibility of them as a new kind of drug carrier system. Some physicochemical properties of stearic acid nanoparticles were studied and morphology examined by transmission electron microscope. Cyclosporin A as a model drug was then encapsulated into stearic acid nanoparticles. Following the establishment of high performance liquid chromatography assay for cyclosporin A analysis in stearic acid nanoparticles or blood samples, the encapsulation ratio of cyclosporin A to stearic acid nanoparticles was estimated and pharmacokinetics as well as bioavailability of cyclosporin A stearic acid nanoparticles after oral administration to Wistar rats were studied, using the Sandimmun Neoral(R) (an available microemulsion system of cyclosporin A) as a reference. The mean diameter of cyclosporin A stearic acid nanoparticles was 316.1 nm, while the encapsulation ratio of cyclosporin A to stearic acid nanoparticles reached to 88.36%. It was demonstrated by 1R spectra and differential scanning calorimetry that there was no chemical reaction occurred between the cyclosporin A and stearic acid. The relative bioavailability of cyclosporin A stearic acid nanoparticles over reference was nearly 80%, and the time to reach maximum concentration (T-max) of cyclosporin A after oral administration of cyclosporin A stearic acid nanoparticles was delayed significantly than the reference, suggesting an obvious sustained release effect. The stearic acid nanoparticles might be a very potential drug carrier. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000087551400001
引用统计
被引频次:74[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59132
专题北京大学药学院_药剂学系
作者单位1.Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 142, Japan
2.Beijing Med Univ, Sch Pharmaceut Sci, Dept Pharm, Beijing 100083, Peoples R China
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Zhang, QN,Yie, GQ,Li, Y,et al. Studies on the cyclosporin A loaded stearic acid nanoparticles[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2000,200(2):153-159.
APA Zhang, QN,Yie, GQ,Li, Y,Yang, QS,&Nagai, YT.(2000).Studies on the cyclosporin A loaded stearic acid nanoparticles.INTERNATIONAL JOURNAL OF PHARMACEUTICS,200(2),153-159.
MLA Zhang, QN,et al."Studies on the cyclosporin A loaded stearic acid nanoparticles".INTERNATIONAL JOURNAL OF PHARMACEUTICS 200.2(2000):153-159.
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