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Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain
Huang, C; Li, HT; Shi, YS; Han, JS; Wan, Y
关键词neuropathic pain allodynia ketamine NMDA receptor electroacupuncture opioid peptide
刊名NEUROSCIENCE LETTERS
2004-09-30
DOI10.1016/j.neulet.2004.07.073
368期:3页:327-331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MORPHINE-TOLERANCE ; PERIPHERAL MONONEUROPATHY ; ELECTRICAL-STIMULATION ; NERVE INJURY ; 2 HZ ; RECEPTOR ; HYPERALGESIA ; ACUPUNCTURE ; EFFICACY ; MK-801
英文摘要

Mu-opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists have been shown to attenuate mechanical allodynia in neuropathic pain models. We have previously reported that 2 Hz electroacupuncture (EA) produced analgesia via releasing endogenous opioid peptides (i.e. beta-endorphin and endomorphin) and the activated mu-opioid receptors. The present study aimed to examine whether ketamine, an NMDA receptor antagonist, can enhance the anti-allodynic effects induced by 2 Hz EA in a rat model of neuropathic pain following spinal nerve ligation (SNL). The results are as follows: (1) EA itself or i.p. injection of ketamine reduced mechanical allodynia (i.e. increase in withdrawal threshold). (2) Although injection of ketamine at a low dose (1.0 mg/kg) alone did not influence mechanical withdrawal threshold, combination of ketamine at this dose with EA produced more potent anti-allodynic effect than that induced by EA alone. (3) The anti-allodynic effect of EA combined with ketamine could be reversed by i.p. injection of naloxone (2.0 mg/kg). These results suggested that ketamine potentiate the anti-allodynic of EA in rats with spinal nerve ligation, and endogenous opioid system is likely to be involved, in this process. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000224288700018
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被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59135
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China
2.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Peoples R China
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GB/T 7714
Huang, C,Li, HT,Shi, YS,et al. Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain[J]. NEUROSCIENCE LETTERS,2004,368(3):327-331.
APA Huang, C,Li, HT,Shi, YS,Han, JS,&Wan, Y.(2004).Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain.NEUROSCIENCE LETTERS,368(3),327-331.
MLA Huang, C,et al."Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain".NEUROSCIENCE LETTERS 368.3(2004):327-331.
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