北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain
作者: Huang, C; Li, HT; Shi, YS; Han, JS; Wan, Y
关键词: neuropathic pain ; allodynia ; ketamine ; NMDA receptor ; electroacupuncture ; opioid peptide
刊名: NEUROSCIENCE LETTERS
发表日期: 2004-09-30
DOI: 10.1016/j.neulet.2004.07.073
卷: 368, 期:3, 页:327-331
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MORPHINE-TOLERANCE ; PERIPHERAL MONONEUROPATHY ; ELECTRICAL-STIMULATION ; NERVE INJURY ; 2 HZ ; RECEPTOR ; HYPERALGESIA ; ACUPUNCTURE ; EFFICACY ; MK-801
英文摘要:

Mu-opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists have been shown to attenuate mechanical allodynia in neuropathic pain models. We have previously reported that 2 Hz electroacupuncture (EA) produced analgesia via releasing endogenous opioid peptides (i.e. beta-endorphin and endomorphin) and the activated mu-opioid receptors. The present study aimed to examine whether ketamine, an NMDA receptor antagonist, can enhance the anti-allodynic effects induced by 2 Hz EA in a rat model of neuropathic pain following spinal nerve ligation (SNL). The results are as follows: (1) EA itself or i.p. injection of ketamine reduced mechanical allodynia (i.e. increase in withdrawal threshold). (2) Although injection of ketamine at a low dose (1.0 mg/kg) alone did not influence mechanical withdrawal threshold, combination of ketamine at this dose with EA produced more potent anti-allodynic effect than that induced by EA alone. (3) The anti-allodynic effect of EA combined with ketamine could be reversed by i.p. injection of naloxone (2.0 mg/kg). These results suggested that ketamine potentiate the anti-allodynic of EA in rats with spinal nerve ligation, and endogenous opioid system is likely to be involved, in this process. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000224288700018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59135
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain.pdf(91KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China
2.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Peoples R China

Recommended Citation:
Huang, C,Li, HT,Shi, YS,et al. Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain[J]. NEUROSCIENCE LETTERS,2004,368(3):327-331.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, C]'s Articles
[Li, HT]'s Articles
[Shi, YS]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, C]‘s Articles
[Li, HT]‘s Articles
[Shi, YS]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace