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Embryotoxic and Teratogenic Effects of the Combination of Bisphenol A and Genistein on In Vitro Cultured Postimplantation Rat Embryos
Xing, Lina; Xu, Yajun2; Xiao, Yang; Shang, Lanqin; Liu, Ran; Wei, Xuetao; Jiang, Jianjun; Hao, Weidong1
关键词bisphenol A genistein embryotoxicity teratogenicity combined effects whole-embryo culture
刊名TOXICOLOGICAL SCIENCES
2010-06-01
DOI10.1093/toxsci/kfq081
115期:2页:577-588
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
资助者National Natural Sciences Foundations of the People&prime ; s Republic of China ; Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan Period ; National Natural Sciences Foundations of the People&prime ; s Republic of China ; Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan Period
研究领域[WOS]Toxicology
关键词[WOS]PURIFIED SOY ISOFLAVONES ; ENVIRONMENTAL ESTROGEN ; ENDOCRINE DISRUPTORS ; AMNIOTIC-FLUID ; XENOPUS-LAEVIS ; EXPOSURE ; PHYTOESTROGENS ; BRAIN ; PHARMACOKINETICS ; DIFFERENTIATION
英文摘要

The potential teratogenic effects and fetal toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years, and they have yet to be fully characterized. In the present study, the teratogenic effects of bisphenol A (BPA) and genistein (GEN) on rat embryos during their critical period of organogenesis were investigated using a whole-embryo culture experiment. The combined exposure effects of BPA and GEN were explored using a 4 x 4 full factorial design. Both BPA and GEN produced concentration-dependent inhibition of embryonic development, beginning at 32.0 and 10.0 mu g/ml, respectively. Full factorial and isobologram analyses revealed a significant synergistic interaction between BPA and GEN for most end points (12 out of 20 tested), as indicated by the enhanced developmental toxicity of BPA after coexposure with different dose levels of GEN. In particular, serious malformations and a higher abnormal frequency of the central nervous system were induced by the combination of BPA and GEN. Our findings suggest that GEN may be embryotoxic and teratogenic to humans. BPA alone may not be a potential teratogen, but these two estrogenic chemicals have a synergistic effect on embryonic development when present together during the critical period of major organ formation. The current findings suggest that pregnant women should not take soy supplements, but more studies are necessary to provide a conclusive recommendation.

语种英语
所属项目编号30771821 ; 2006BKA02A02
资助者National Natural Sciences Foundations of the People&prime ; s Republic of China ; Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan Period ; National Natural Sciences Foundations of the People&prime ; s Republic of China ; Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan Period
WOS记录号WOS:000277997100027
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59138
专题北京大学公共卫生学院_毒理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xing, Lina,Xu, Yajun,Xiao, Yang,et al. Embryotoxic and Teratogenic Effects of the Combination of Bisphenol A and Genistein on In Vitro Cultured Postimplantation Rat Embryos[J]. TOXICOLOGICAL SCIENCES,2010,115(2):577-588.
APA Xing, Lina.,Xu, Yajun.,Xiao, Yang.,Shang, Lanqin.,Liu, Ran.,...&Hao, Weidong.(2010).Embryotoxic and Teratogenic Effects of the Combination of Bisphenol A and Genistein on In Vitro Cultured Postimplantation Rat Embryos.TOXICOLOGICAL SCIENCES,115(2),577-588.
MLA Xing, Lina,et al."Embryotoxic and Teratogenic Effects of the Combination of Bisphenol A and Genistein on In Vitro Cultured Postimplantation Rat Embryos".TOXICOLOGICAL SCIENCES 115.2(2010):577-588.
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