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Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms
Zhang, YH; Fang, LH
关键词antinociception 5-HT morphine serotonergic tail flick tetrandrine
刊名LIFE SCIENCES
2001-08-10
69期:12页:1429-1439
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]RECEPTOR-MEDIATED BEHAVIOR ; HEAD-TWITCH RESPONSE ; THERMAL ALGESIC TESTS ; FORMALIN TEST ; UP-REGULATION ; D-AMPHETAMINE ; SPINAL-CORD ; ANALGESIA ; MICE ; TOLERANCE
英文摘要

(1)Tetrandrine (TET), a non-specific calcium antagonist, inhibited morphine-induced antinociception. in the tail-flick test in mice. This study was undertaken to assess the mechanism of the antagonism of morphine-induced antinociception by TET. Morphine-induced antinociception. was prevented by pretreatment with TET in the tail-flick but not in the tail-pinch tests carried out in mice and this antagonism was abolished by pretreatment of a serotonin precursor, 5-hydroxytryptophan (5-HTP), but not by the pretreatment of a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA), in the tail-flick test. These results indicate that serotonergic mechanisms are involved in the antagonism of morphine-induced antinociception by TET. On the other hand, the development of morphine-induced analgesic tolerance was not prevented by TET. This result, in agreement with other reports, also indicates the possible dissociation of morphine analgesic effect from its tolerance-inducing effect. In addition, TET suppressed the 5-hydroxytryptamine (5-HT)-induced head twtch response. This result provides additional evidence that TET may modulate serotonergic function and the antagonism of morphine-induced antinociception by TET is dependent on serotonergic mechanisms. (C) 2001 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000170530500008
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59140
专题北京大学基础医学院_药理学系
作者单位1.Chungbuk Natl Univ, Coll Med, Dept Pharmacol, Kaeshin Dong 361763, Cheongju, South Korea
2.Beijing Univ, Dept Pharmacol, Sch Basic Med, Beijing 100083, Peoples R China
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Zhang, YH,Fang, LH. Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms[J]. LIFE SCIENCES,2001,69(12):1429-1439.
APA Zhang, YH,&Fang, LH.(2001).Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms.LIFE SCIENCES,69(12),1429-1439.
MLA Zhang, YH,et al."Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms".LIFE SCIENCES 69.12(2001):1429-1439.
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