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学科主题: 基础医学
题名:
Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms
作者: Zhang, YH; Fang, LH
关键词: antinociception ; 5-HT ; morphine ; serotonergic ; tail flick ; tetrandrine
刊名: LIFE SCIENCES
发表日期: 2001-08-10
卷: 69, 期:12, 页:1429-1439
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: RECEPTOR-MEDIATED BEHAVIOR ; HEAD-TWITCH RESPONSE ; THERMAL ALGESIC TESTS ; FORMALIN TEST ; UP-REGULATION ; D-AMPHETAMINE ; SPINAL-CORD ; ANALGESIA ; MICE ; TOLERANCE
英文摘要:

(1)Tetrandrine (TET), a non-specific calcium antagonist, inhibited morphine-induced antinociception. in the tail-flick test in mice. This study was undertaken to assess the mechanism of the antagonism of morphine-induced antinociception by TET. Morphine-induced antinociception. was prevented by pretreatment with TET in the tail-flick but not in the tail-pinch tests carried out in mice and this antagonism was abolished by pretreatment of a serotonin precursor, 5-hydroxytryptophan (5-HTP), but not by the pretreatment of a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA), in the tail-flick test. These results indicate that serotonergic mechanisms are involved in the antagonism of morphine-induced antinociception by TET. On the other hand, the development of morphine-induced analgesic tolerance was not prevented by TET. This result, in agreement with other reports, also indicates the possible dissociation of morphine analgesic effect from its tolerance-inducing effect. In addition, TET suppressed the 5-hydroxytryptamine (5-HT)-induced head twtch response. This result provides additional evidence that TET may modulate serotonergic function and the antagonism of morphine-induced antinociception by TET is dependent on serotonergic mechanisms. (C) 2001 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000170530500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59140
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Chungbuk Natl Univ, Coll Med, Dept Pharmacol, Kaeshin Dong 361763, Cheongju, South Korea
2.Beijing Univ, Dept Pharmacol, Sch Basic Med, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, YH,Fang, LH. Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms[J]. LIFE SCIENCES,2001,69(12):1429-1439.
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