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Decreased striatal dopamine transporters in codeine-containing cough syrup abusers
Hou, Haifeng1; Yin, Shugui2; Jia, Shaowei1,3; Hu, Shu1; Sun, Taotao1; Chen, Qing1; Fan, Rong1
关键词Codeine-containing cough syrups Cough medicine Dopamine transporter (DAT) SPECT Dependence Abuse
刊名DRUG AND ALCOHOL DEPENDENCE
2011-11-01
DOI10.1016/j.drugalcdep.2011.03.011
118期:2-3页:148-151
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse ; Psychiatry
研究领域[WOS]Substance Abuse ; Psychiatry
关键词[WOS]DEPENDENT PATIENTS ; HEROIN USERS ; DRUG-ABUSE ; BLOOD-FLOW ; METHAMPHETAMINE ; RECOVERY ; MORPHINE ; NEUROTOXICITY ; ADDICTION ; MAINTENANCE
英文摘要

Background: In recent years, codeine-containing cough syrups (CCS) have been reported as substances of abuse, especially in adolescents. Chronic CCS abuse can induce physical and psychological dependence. However, the potential brain impairment caused by chronic CCS abuse has not been reported previously. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in CCS-dependent subjects and to explore the CCS-caused brain impairment.

Methods: SPECT brain scans were acquired on 22 CCS-dependent subjects and 27 healthy age matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the 99mTc-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models.

Results: It was displayed that DAT availability of striatum was significantly decreased and the V. Wand Ra were greatly reduced in the CCS-dependent group compared to controls (for each comparison p < 0.01).

Conclusion: Taken together, these results suggest that chronic CCS abuse may cause serious damage to the brain and the neuroimaging findings further illustrate the mechanism of CCS dependence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000296173800009
项目编号2008B090500129 ; 2009B090300204 ; 06027973 ; A2007592
资助机构Guangdong Science and Technology Department (Guangdong Province and Ministry of Education) ; Guangdong Natural Science Fund Committee (Natural Science Foundation of Guangdong Province) ; Guangdong Health Department
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59142
专题北京大学深圳医院_核医学科
作者单位1.Shenzhen Civil Life Sci & Technol Co Ltd, Shenzhen, Peoples R China
2.Peking Univ, Dept Nucl Med, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Grad Sch, Shenzhen 518036, Peoples R China
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GB/T 7714
Hou, Haifeng,Yin, Shugui,Jia, Shaowei,et al. Decreased striatal dopamine transporters in codeine-containing cough syrup abusers[J]. DRUG AND ALCOHOL DEPENDENCE,2011,118(2-3):148-151.
APA Hou, Haifeng.,Yin, Shugui.,Jia, Shaowei.,Hu, Shu.,Sun, Taotao.,...&Fan, Rong.(2011).Decreased striatal dopamine transporters in codeine-containing cough syrup abusers.DRUG AND ALCOHOL DEPENDENCE,118(2-3),148-151.
MLA Hou, Haifeng,et al."Decreased striatal dopamine transporters in codeine-containing cough syrup abusers".DRUG AND ALCOHOL DEPENDENCE 118.2-3(2011):148-151.
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