|Decreased striatal dopamine transporters in codeine-containing cough syrup abusers|
|Hou, Haifeng1; Yin, Shugui2; Jia, Shaowei1,3; Hu, Shu1; Sun, Taotao1; Chen, Qing1; Fan, Rong1|
|关键词||Codeine-containing cough syrups Cough medicine Dopamine transporter (DAT) SPECT Dependence Abuse|
|刊名||DRUG AND ALCOHOL DEPENDENCE|
|WOS标题词||Science & Technology|
|类目[WOS]||Substance Abuse ; Psychiatry|
|研究领域[WOS]||Substance Abuse ; Psychiatry|
|关键词[WOS]||DEPENDENT PATIENTS ; HEROIN USERS ; DRUG-ABUSE ; BLOOD-FLOW ; METHAMPHETAMINE ; RECOVERY ; MORPHINE ; NEUROTOXICITY ; ADDICTION ; MAINTENANCE|
Background: In recent years, codeine-containing cough syrups (CCS) have been reported as substances of abuse, especially in adolescents. Chronic CCS abuse can induce physical and psychological dependence. However, the potential brain impairment caused by chronic CCS abuse has not been reported previously. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in CCS-dependent subjects and to explore the CCS-caused brain impairment.
Methods: SPECT brain scans were acquired on 22 CCS-dependent subjects and 27 healthy age matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the 99mTc-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models.
Results: It was displayed that DAT availability of striatum was significantly decreased and the V. Wand Ra were greatly reduced in the CCS-dependent group compared to controls (for each comparison p < 0.01).
Conclusion: Taken together, these results suggest that chronic CCS abuse may cause serious damage to the brain and the neuroimaging findings further illustrate the mechanism of CCS dependence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
|项目编号||2008B090500129 ; 2009B090300204 ; 06027973 ; A2007592|
|资助机构||Guangdong Science and Technology Department (Guangdong Province and Ministry of Education) ; Guangdong Natural Science Fund Committee (Natural Science Foundation of Guangdong Province) ; Guangdong Health Department|
|作者单位||1.Shenzhen Civil Life Sci & Technol Co Ltd, Shenzhen, Peoples R China|
2.Peking Univ, Dept Nucl Med, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Grad Sch, Shenzhen 518036, Peoples R China
|Hou, Haifeng,Yin, Shugui,Jia, Shaowei,et al. Decreased striatal dopamine transporters in codeine-containing cough syrup abusers[J]. DRUG AND ALCOHOL DEPENDENCE,2011,118(2-3):148-151.|
|APA||Hou, Haifeng.,Yin, Shugui.,Jia, Shaowei.,Hu, Shu.,Sun, Taotao.,...&Fan, Rong.(2011).Decreased striatal dopamine transporters in codeine-containing cough syrup abusers.DRUG AND ALCOHOL DEPENDENCE,118(2-3),148-151.|
|MLA||Hou, Haifeng,et al."Decreased striatal dopamine transporters in codeine-containing cough syrup abusers".DRUG AND ALCOHOL DEPENDENCE 118.2-3(2011):148-151.|