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学科主题: 临床医学
题名:
Decreased striatal dopamine transporters in codeine-containing cough syrup abusers
作者: Hou, Haifeng1; Yin, Shugui2; Jia, Shaowei1,3; Hu, Shu1; Sun, Taotao1; Chen, Qing1; Fan, Rong1
关键词: Codeine-containing cough syrups ; Cough medicine ; Dopamine transporter (DAT) ; SPECT ; Dependence ; Abuse
刊名: DRUG AND ALCOHOL DEPENDENCE
发表日期: 2011-11-01
DOI: 10.1016/j.drugalcdep.2011.03.011
卷: 118, 期:2-3, 页:148-151
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse ; Psychiatry
研究领域[WOS]: Substance Abuse ; Psychiatry
关键词[WOS]: DEPENDENT PATIENTS ; HEROIN USERS ; DRUG-ABUSE ; BLOOD-FLOW ; METHAMPHETAMINE ; RECOVERY ; MORPHINE ; NEUROTOXICITY ; ADDICTION ; MAINTENANCE
英文摘要:

Background: In recent years, codeine-containing cough syrups (CCS) have been reported as substances of abuse, especially in adolescents. Chronic CCS abuse can induce physical and psychological dependence. However, the potential brain impairment caused by chronic CCS abuse has not been reported previously. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in CCS-dependent subjects and to explore the CCS-caused brain impairment.

Methods: SPECT brain scans were acquired on 22 CCS-dependent subjects and 27 healthy age matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the 99mTc-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models.

Results: It was displayed that DAT availability of striatum was significantly decreased and the V. Wand Ra were greatly reduced in the CCS-dependent group compared to controls (for each comparison p < 0.01).

Conclusion: Taken together, these results suggest that chronic CCS abuse may cause serious damage to the brain and the neuroimaging findings further illustrate the mechanism of CCS dependence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2008B090500129 ; 2009B090300204 ; 06027973 ; A2007592
项目资助者: Guangdong Science and Technology Department (Guangdong Province and Ministry of Education) ; Guangdong Natural Science Fund Committee (Natural Science Foundation of Guangdong Province) ; Guangdong Health Department
WOS记录号: WOS:000296173800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59142
Appears in Collections:北京大学深圳医院_核医学科_期刊论文

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作者单位: 1.Shenzhen Civil Life Sci & Technol Co Ltd, Shenzhen, Peoples R China
2.Peking Univ, Dept Nucl Med, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Grad Sch, Shenzhen 518036, Peoples R China

Recommended Citation:
Hou, Haifeng,Yin, Shugui,Jia, Shaowei,et al. Decreased striatal dopamine transporters in codeine-containing cough syrup abusers[J]. DRUG AND ALCOHOL DEPENDENCE,2011,118(2-3):148-151.
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