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学科主题: 基础医学
题名:
Recurrent hepatocellular carcinoma cells with stem cell-like properties: possible targets for immunotherapy
作者: Xu, Xiaolan1,2; Xing, Baocai3; Hu, Meihao2; Xu, Zuoliang1; Xie, Yong4; Dai, Guanghai5; Gu, Jun; Wang, Yu1; Zhang, Zhiqian1
刊名: CYTOTHERAPY
发表日期: 2010-04-01
DOI: 10.3109/14653240903390803
卷: 12, 期:2, 页:190-200
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Hematology ; Medicine, Research & Experimental
研究领域[WOS]: Cell Biology ; Biotechnology & Applied Microbiology ; Hematology ; Research & Experimental Medicine
关键词[WOS]: CANCER STEM/PROGENITOR CELLS ; ACUTE MYELOID-LEUKEMIA ; LIVER-CANCER ; T-CELLS ; IDENTIFICATION ; GENERATION ; CHEMOTHERAPY ; HEPATOCYTES ; LYMPHOCYTES ; GAMMA
英文摘要:

Background aims: Hepatocellular carcinoma (HCC) recurs with high frequency. Characterization of recurrent HCC cells will facilitate the design of future therapeutic strategies for recurrent HCC. Methods: Two cell lines, Hep-11 and Hep-12, were established from the same HCC patient′s primary and recurrent tumor tissues, respectively, and then analyzed for stem cell-like properties, immune evasion strategies and immunogenicity. Results: Compared with Hep-11 cells, Hep-12 cells expressed higher levels of liver progenitor cell makers and displayed persistent tumorigenic potential in the serial transplantation assay. Although Hep-12 cells down-regulated human leukocyte antigen (HLA) class I expression, they could still be recognized and killed by autologous-activated tumor-infiltrating lymphocytes (TIL) in vitro. Pre-treatment with cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) increased the expression of HLA class I molecules on Hep-12 cells, and rendered them more susceptible to CD8

语种: 英语
所属项目编号: 30670413 ; 30671060 ; 2010CB529402 ; NCET-07-0031
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000275110600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59154
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Cell Biol, Beijing Canc Hosp & Inst,Sch Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Inst Life Sci, Natl Key Lab Prot Engn & Plant Gene Engn, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Hepatobilliary Surg 1, Beijing 100142, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China
5.Gen Hosp Chinese Peoples Liberat Army, Dept Med Oncol, Beijing, Peoples R China

Recommended Citation:
Xu, Xiaolan,Xing, Baocai,Hu, Meihao,et al. Recurrent hepatocellular carcinoma cells with stem cell-like properties: possible targets for immunotherapy[J]. CYTOTHERAPY,2010,12(2):190-200.
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