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Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock
Jiang, W; Jiang, HF; Cai, DY; Pan, CS; Qi, YF; Pang, YZ; Tang, CS
关键词septic shock adrenomedullin neutral endopeptidase
刊名REGULATORY PEPTIDES
2004-05-15
DOI10.1016/j.regpep.2003.12.013
118期:3页:199-208
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Physiology
关键词[WOS]BINDING PROTEIN-1 ; SEPSIS ; PEPTIDE ; PROADRENOMEDULLIN ; ABNORMALITIES ; MODULATION ; MICE
英文摘要

Adrenomedullin (ADM), a multifunction peptide with important roles in regulating cardiovascular homeostasis, has the vasodilatory proper-ties and is of particular interest in the pathophysiology of sepsis. ADM levels in plasma and tissues are regulated by the proteolysis of neutral endopeptidase (NEP), the major enzyme of ADM degradation. We observed the NEP activity in the plasma, the activity and distribution of NEP and its mRNA expression in the tissues of rats in septic shock to study the possible role of NEP in elevating tissue ADM concentration during sepsis. ADM level increases progressively during sepsis except in the jejunum. Rats in early phase of shock (ES) showed diverse changes in tissue NEP activity. Plasma NEP activity, tissue NEP activity and its protein and mRNA expression in the left ventricle, aorta, jejunum and lung in the late phase of shock (LS) rats were lower than those in ES and the control, but no statistical change of NEP activity in the kidney was observed. The level of ADM was inversely correlated with NEP activity in the plasma, ventricle and aorta and positively correlated with NEP activity in the jejunum. Thus, in sepsis, the local concentration and action of ADM in tissues may be differentially regulated by NEP. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000220320300011
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59157
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Physiol, Beijing 100083, Peoples R China
3.Minist Hlth Cardiovasc Mol Biol & Regulatory Pept, Reference Lab, Beijing 100083, Peoples R China
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Jiang, W,Jiang, HF,Cai, DY,et al. Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock[J]. REGULATORY PEPTIDES,2004,118(3):199-208.
APA Jiang, W.,Jiang, HF.,Cai, DY.,Pan, CS.,Qi, YF.,...&Tang, CS.(2004).Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock.REGULATORY PEPTIDES,118(3),199-208.
MLA Jiang, W,et al."Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock".REGULATORY PEPTIDES 118.3(2004):199-208.
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