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学科主题: 基础医学
题名:
Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats
作者: Ma, Yao-Ying1,2,3,4; Meng, Li1,2,3; Guo, Chang-Yong1,2,3,4; Han, Ji-Sheng1,2,3,4; Lee, David Yue-Wei4; Cui, Cai-Lian1,2,3,4
关键词: Conditioned place preference (CPP) ; Mesolimbic dopamine system (MLDS) ; HPLC ; Drug-associated environmental cue
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2009-12-01
DOI: 10.1016/j.bbr.2009.06.017
卷: 204, 期:1, 页:192-199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; INCENTIVE SALIENCE ; GENE-EXPRESSION ; NMDA RECEPTOR ; REWARD ; REINSTATEMENT ; COCAINE ; STRESS ; REINFORCERS ; INHIBITION
英文摘要:

The dopamine (DA) projections from the ventral tegmental area to the nucleus accumbens (NAc) are the key component of the brain reward circuitry. The encoded information by DA in reward-related memory within this circuit during opiate reinforcement requires further clarification. The present study was designed to explore the correlations between morphine dose, retention of morphine-induced conditioned place preference (CPP), morphine-induced changes in levels of DA and its metabolites in the NAc in expression and retention of CPP in Sprague-Dawley male rats. A dose-effect curve for morphine-induced CPP (0.01-10 mg/kg, i.p.) was obtained using 4-day conditioning sessions followed by a CPP test; the retention of morphine CPP was measured with CPP tests after the development of CPP. We found a dose-dependent effect of morphine (from 0.01 to 10.0 mg/kg, i.p.) on both the magnitude and the retention of CPP. During the retention of morphine-induced CPP, a morphine-dose- and time-dependent elevation of DA and its metabolites was observed in the NAc. These changes were absent if the same dose of morphine was injected outside of the conditioning environment (i.e., in the home cage). These results suggest that that the long-lasting elevation of DA and its metabolites in the NAc is attributable mainly to drug-associated context, rather than the residual effect of morphine. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30570583 ; 2009CB522003
项目资助者: National Natural Science Foundation ; National Basic Research Program
WOS记录号: WOS:000269459700021
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59158
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
3.Minist Publ Hlth, Beijing 100083, Peoples R China
4.Harvard Univ, Sch Med, McLean Hosp, Alternat Med Ctr, Belmont, MA 02478 USA

Recommended Citation:
Ma, Yao-Ying,Meng, Li,Guo, Chang-Yong,et al. Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats[J]. BEHAVIOURAL BRAIN RESEARCH,2009,204(1):192-199.
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