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Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats
Ma, Yao-Ying1,2,3,4; Meng, Li1,2,3; Guo, Chang-Yong1,2,3,4; Han, Ji-Sheng1,2,3,4; Lee, David Yue-Wei4; Cui, Cai-Lian1,2,3,4
关键词Conditioned Place Preference (Cpp) Mesolimbic Dopamine System (Mlds) Hplc Drug-associated Environmental Cue
刊名BEHAVIOURAL BRAIN RESEARCH
2009-12-01
DOI10.1016/j.bbr.2009.06.017
204期:1页:192-199
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; INCENTIVE SALIENCE ; GENE-EXPRESSION ; NMDA RECEPTOR ; REWARD ; REINSTATEMENT ; COCAINE ; STRESS ; REINFORCERS ; INHIBITION
英文摘要

The dopamine (DA) projections from the ventral tegmental area to the nucleus accumbens (NAc) are the key component of the brain reward circuitry. The encoded information by DA in reward-related memory within this circuit during opiate reinforcement requires further clarification. The present study was designed to explore the correlations between morphine dose, retention of morphine-induced conditioned place preference (CPP), morphine-induced changes in levels of DA and its metabolites in the NAc in expression and retention of CPP in Sprague-Dawley male rats. A dose-effect curve for morphine-induced CPP (0.01-10 mg/kg, i.p.) was obtained using 4-day conditioning sessions followed by a CPP test; the retention of morphine CPP was measured with CPP tests after the development of CPP. We found a dose-dependent effect of morphine (from 0.01 to 10.0 mg/kg, i.p.) on both the magnitude and the retention of CPP. During the retention of morphine-induced CPP, a morphine-dose- and time-dependent elevation of DA and its metabolites was observed in the NAc. These changes were absent if the same dose of morphine was injected outside of the conditioning environment (i.e., in the home cage). These results suggest that that the long-lasting elevation of DA and its metabolites in the NAc is attributable mainly to drug-associated context, rather than the residual effect of morphine. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000269459700021
项目编号30570583 ; 2009CB522003
资助机构National Natural Science Foundation ; National Basic Research Program
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59158
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
3.Minist Publ Hlth, Beijing 100083, Peoples R China
4.Harvard Univ, Sch Med, McLean Hosp, Alternat Med Ctr, Belmont, MA 02478 USA
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Ma, Yao-Ying,Meng, Li,Guo, Chang-Yong,et al. Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats[J]. BEHAVIOURAL BRAIN RESEARCH,2009,204(1):192-199.
APA Ma, Yao-Ying,Meng, Li,Guo, Chang-Yong,Han, Ji-Sheng,Lee, David Yue-Wei,&Cui, Cai-Lian.(2009).Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats.BEHAVIOURAL BRAIN RESEARCH,204(1),192-199.
MLA Ma, Yao-Ying,et al."Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats".BEHAVIOURAL BRAIN RESEARCH 204.1(2009):192-199.
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