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Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma
Chen, Ya-Hong1; Wu, Rui1; Geng, Bin2; Qi, Yong-Fen2; Wang, Pei-Pei1; Yao, Wan-Zhen1; Tang, Chao-Shu2
关键词Asthma Hydrogen sulfide Airway inflammation Airway remodeling inducible nitric oxide synthase
刊名CYTOKINE
2009-02-01
DOI10.1016/j.cyto.2008.11.009
45期:2页:117-123
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]NF-KAPPA-B ; PULMONARY-HYPERTENSION ; LIPOPOLYSACCHARIDE ; INHIBITOR ; INJURY ; NEUROMODULATOR ; EXPRESSION ; CYTOKINES ; MEDIATOR ; PATHWAY
英文摘要

Endogenous hydrogen sulfide (H(2)S) is hypothesized to have an important role in systemic inflammation. We investigated if endogenous H(2)S may be a crucial mediator in airway inflammation and airway remodeling in a rat model of asthma and if endogenous H(2)S may exert its anti-inflammatory effect by inhibiting inducible nitric oxide synthase (iNOS)/NO pathway. Cystathionine-gamma-lyase (CSE; a H(2)S-synthesizing enzyme) was mainly expressed in airway and vascular smooth muscle cells in rat lung tissue. Levels of endogenous H(2)S was decreased in pulmonary tissue in ovalbumin (OVA)-treated rats. Exogenous administration of NaHS alleviated airway inflammation and airway remodeling: peak expiratory flow (PEF) increased, goblet cell hyperplasia and collagen deposition score decreased, with decreased total cells recovered from bronchoalveolar fluid (BALF) and influx of eosinophils and neutrophils. The H(2)S levels of serum and lung tissue were positively correlated with PEF and negatively correlated with the level of eosinophils and neutrophils in BALF, score of lung pathology. NaHS treatment significantly attenuated pulmonary iNOS activation in OVA-treated rats. These results suggest that the CSE/H(2)S pathway plays an anti-inflammatory and anti-remodeling part in asthma pathogenesis and could be a novel target in prevention and treatment of asthma. (C) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000264038900011
项目编号985-2-082-113 ; 2005A07 ; 30871127
资助机构Program for New Century Excellent Talents in University ; Program of Beijing Scientific and Technological New Star ; National Natural Science Foundation of China
引用统计
被引频次:81[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59159
专题北京大学第三临床医学院_呼吸科
北京大学基础医学院
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Resp Dept, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, Ya-Hong,Wu, Rui,Geng, Bin,et al. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma[J]. CYTOKINE,2009,45(2):117-123.
APA Chen, Ya-Hong.,Wu, Rui.,Geng, Bin.,Qi, Yong-Fen.,Wang, Pei-Pei.,...&Tang, Chao-Shu.(2009).Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma.CYTOKINE,45(2),117-123.
MLA Chen, Ya-Hong,et al."Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma".CYTOKINE 45.2(2009):117-123.
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