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学科主题: 临床医学
题名:
Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma
作者: Chen, Ya-Hong1; Wu, Rui1; Geng, Bin2; Qi, Yong-Fen2; Wang, Pei-Pei1; Yao, Wan-Zhen1; Tang, Chao-Shu2
关键词: Asthma ; Hydrogen sulfide ; Airway inflammation ; Airway remodeling ; inducible nitric oxide synthase
刊名: CYTOKINE
发表日期: 2009-02-01
DOI: 10.1016/j.cyto.2008.11.009
卷: 45, 期:2, 页:117-123
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]: NF-KAPPA-B ; PULMONARY-HYPERTENSION ; LIPOPOLYSACCHARIDE ; INHIBITOR ; INJURY ; NEUROMODULATOR ; EXPRESSION ; CYTOKINES ; MEDIATOR ; PATHWAY
英文摘要:

Endogenous hydrogen sulfide (H(2)S) is hypothesized to have an important role in systemic inflammation. We investigated if endogenous H(2)S may be a crucial mediator in airway inflammation and airway remodeling in a rat model of asthma and if endogenous H(2)S may exert its anti-inflammatory effect by inhibiting inducible nitric oxide synthase (iNOS)/NO pathway. Cystathionine-gamma-lyase (CSE; a H(2)S-synthesizing enzyme) was mainly expressed in airway and vascular smooth muscle cells in rat lung tissue. Levels of endogenous H(2)S was decreased in pulmonary tissue in ovalbumin (OVA)-treated rats. Exogenous administration of NaHS alleviated airway inflammation and airway remodeling: peak expiratory flow (PEF) increased, goblet cell hyperplasia and collagen deposition score decreased, with decreased total cells recovered from bronchoalveolar fluid (BALF) and influx of eosinophils and neutrophils. The H(2)S levels of serum and lung tissue were positively correlated with PEF and negatively correlated with the level of eosinophils and neutrophils in BALF, score of lung pathology. NaHS treatment significantly attenuated pulmonary iNOS activation in OVA-treated rats. These results suggest that the CSE/H(2)S pathway plays an anti-inflammatory and anti-remodeling part in asthma pathogenesis and could be a novel target in prevention and treatment of asthma. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 985-2-082-113 ; 2005A07 ; 30871127
项目资助者: Program for New Century Excellent Talents in University ; Program of Beijing Scientific and Technological New Star ; National Natural Science Foundation of China
WOS记录号: WOS:000264038900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59159
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Resp Dept, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Ya-Hong,Wu, Rui,Geng, Bin,et al. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma[J]. CYTOKINE,2009,45(2):117-123.
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