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学科主题: 临床医学
题名:
Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs
作者: Li Li-juan; Chen Wei; Xu Hui; Wan Zhe; Li Ruo-yu; Liu Wei
关键词: aspergillus spp. ; ibuprofen ; antifungal susceptibility ; drug interaction
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-10-05
DOI: 10.3760/cma.j.issn.0366-6999.2010.19.015
卷: 123, 期:19, 页:2701-2705
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INVASIVE ASPERGILLOSIS ; IN-VITRO ; CANDIDA-ALBICANS ; SYNERGY ; FLUCONAZOLE ; INFECTIONS ; ANTAGONISM ; AGENTS
英文摘要:

Background The incidence of invasive aspergillosis (IA) has increased in frequency in immunocompromised patients with a variety of diseases. The poor prognosis might be due to limited treatment option. This study aimed to evaluate antifungal activity of ibuprofen against clinical isolates of aspergillus species, as well as its interaction with azoles or with amphotericin B or with micafungin.

Methods Antifungal activity of ibuprofen against 10 strains of Aspergillus fumigatus, Aspergillus flavus, and Aspergillus terreus were tested with both disk diffusion assay and standard broth microdilution method. To determine whether ibuprofen combined with itraconazole, voriconazole, amphotericin B, or micafungin had interactive effects on aspergillus spp., we used both disk diffusion assay and Chequerboard method.

Results As for disk diffusion method, ibuprofen produced a zone of growth inhibition with diameters of (20.1 +/- 3.9) mm at 48 hours of incubation. As for broth microdilution method, the minimal inhibitory concentration (MIC) ranges of ibuprofen against aspergillus spp. were 1000-2000 mu g/ml, and the minimal fungicidal concentration (MFC) ranges of that was 2000-8000 mu g/ml. For 2 of 5 isolates, when ibuprofen combined with itraconazole or voriconazole, the zones of growth inhibition were larger than those of the individual drug. The results of Chequerboard method showed that fractional inhibitory concentration index (FICI) ranges were 1.125-2.500.

Conclusions Ibuprofen is active against aspergillus spp.. And ibuprofen does not affect the in vitro activity of itraconazole, voriconazole, amphotericin B or micafungin against aspergillus spp.. Chin Med J 2010;123(19):2701-2705

语种: 英语
所属项目编号: 30970131 ; 107002
项目资助者: National Natural Science Foundation of China ; Chinese Ministry of Education
WOS记录号: WOS:000283562300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59160
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: Peking Univ, Res Ctr Med Mycol, Peking Univ Hosp 1, Dept Dermatovenerol, Beijing 100034, Peoples R China

Recommended Citation:
Li Li-juan,Chen Wei,Xu Hui,et al. Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs[J]. CHINESE MEDICAL JOURNAL,2010,123(19):2701-2705.
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