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学科主题临床医学
Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs
Li Li-juan; Chen Wei; Xu Hui; Wan Zhe; Li Ruo-yu; Liu Wei
关键词aspergillus spp. ibuprofen antifungal susceptibility drug interaction
刊名CHINESE MEDICAL JOURNAL
2010-10-05
DOI10.3760/cma.j.issn.0366-6999.2010.19.015
123期:19页:2701-2705
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INVASIVE ASPERGILLOSIS ; IN-VITRO ; CANDIDA-ALBICANS ; SYNERGY ; FLUCONAZOLE ; INFECTIONS ; ANTAGONISM ; AGENTS
英文摘要

Background The incidence of invasive aspergillosis (IA) has increased in frequency in immunocompromised patients with a variety of diseases. The poor prognosis might be due to limited treatment option. This study aimed to evaluate antifungal activity of ibuprofen against clinical isolates of aspergillus species, as well as its interaction with azoles or with amphotericin B or with micafungin.

Methods Antifungal activity of ibuprofen against 10 strains of Aspergillus fumigatus, Aspergillus flavus, and Aspergillus terreus were tested with both disk diffusion assay and standard broth microdilution method. To determine whether ibuprofen combined with itraconazole, voriconazole, amphotericin B, or micafungin had interactive effects on aspergillus spp., we used both disk diffusion assay and Chequerboard method.

Results As for disk diffusion method, ibuprofen produced a zone of growth inhibition with diameters of (20.1 +/- 3.9) mm at 48 hours of incubation. As for broth microdilution method, the minimal inhibitory concentration (MIC) ranges of ibuprofen against aspergillus spp. were 1000-2000 mu g/ml, and the minimal fungicidal concentration (MFC) ranges of that was 2000-8000 mu g/ml. For 2 of 5 isolates, when ibuprofen combined with itraconazole or voriconazole, the zones of growth inhibition were larger than those of the individual drug. The results of Chequerboard method showed that fractional inhibitory concentration index (FICI) ranges were 1.125-2.500.

Conclusions Ibuprofen is active against aspergillus spp.. And ibuprofen does not affect the in vitro activity of itraconazole, voriconazole, amphotericin B or micafungin against aspergillus spp.. Chin Med J 2010;123(19):2701-2705

语种英语
WOS记录号WOS:000283562300015
项目编号30970131 ; 107002
资助机构National Natural Science Foundation of China ; Chinese Ministry of Education
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59160
专题北京大学第一临床医学院_皮肤性病科
北京大学第三临床医学院_药剂科
作者单位Peking Univ, Res Ctr Med Mycol, Peking Univ Hosp 1, Dept Dermatovenerol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li Li-juan,Chen Wei,Xu Hui,et al. Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs[J]. CHINESE MEDICAL JOURNAL,2010,123(19):2701-2705.
APA Li Li-juan,Chen Wei,Xu Hui,Wan Zhe,Li Ruo-yu,&Liu Wei.(2010).Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs.CHINESE MEDICAL JOURNAL,123(19),2701-2705.
MLA Li Li-juan,et al."Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs".CHINESE MEDICAL JOURNAL 123.19(2010):2701-2705.
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