IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Sustained-Release Oxycodone Tablets for Moderate to Severe Painful Diabetic Peripheral Neuropathy: A Multicenter, Open-Labeled, Postmarketing Clinical Observation
Yao Peng1; Meng Ling-Xin1; Ma Jia-Ming1; Ding Yuan-Yuan1; Wang Zhi-Bin1; Zhao Guo-Li2; Tao Rong3; Wu Yan-Xiang4; Wang Qiu-Shi5; Zhang Zhen6; Zhao Yong-Dong7,8; Zhang Shao-Wei8; Liu Jin-Feng9; Guo Hong-Jie10; Xu Gang11; Wu Bai-Shan12
关键词Diabetic Peripheral Neuropathy Pain Analgesic Sustained-Release Oxycodone Opioid Adverse Reactions
刊名PAIN MEDICINE
2012
DOI10.1111/j.1526-4637.2011.01274.x
13期:1页:107-114
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MANAGEMENT
英文摘要

Objective. To evaluate the efficacy and safety of sustained-release (SR) oxycodone tablets in the treatment of moderate to severe painful diabetic peripheral neuropathy (DPN).

Design. This was a multicenter, randomized, open-labeled study.

Setting. This study was completed in 12 hospitals in China.

Patients. A total of 80 Chinese patients undergoing moderate to severe painful DPN.

Interventions. An initial dose of 10 mg is recommended to be taken orally every 12 hours. Dose titration was done appropriately according to pain intensity and adverse reactions.

Outcome Measures. Data record included days, dosage, analgesic efficacy, quality of sleep, adverse events, and combination therapy when patients were treated with SR oxycodone tablets. The continuous observation period was 6 weeks.

Results. After medication for 1 week, pain was significantly (P < 0.01) relieved from 6.8 +/- 1.4 to 2.8 +/- 1.6. Onset time was within 45 minutes in nearly 60% of the patients, and within 1 hour in nearly 95% of that ones. More than 90% of the patients achieved stable analgesic dose within 3 days. After using SR oxycodone tablets for 1 week, sleep quality was significantly (P < 0.01) improved. In week 1, the average dose of SR oxycodone tablets was 16.63 +/- 7.79 mg. The average daily dose of most patients was about 20 mg after 2 weeks. In all the enrolled patients, 38 (47.5%) had adverse reactions. No serious adverse reactions took place.

Conclusion. The results of this clinical observation further elaborated the efficacy and safety of SR oxycodone tablets in the treatment of moderate to severe painful diabetic peripheral neuropathy in China.

语种英语
WOS记录号WOS:000298954200010
项目编号696
资助机构Mundipharma (China) Pharmaceutical Co. Ltd. ; Liaoning provincial medicine peak construction engineering project
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59165
专题北京大学第一临床医学院
北京大学第一临床医学院_介入血管外科
作者单位1.China Med Univ, Shengjing Hosp, Dept Pain Management, Shenyang, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Pain Management, Beijing, Peoples R China
3.Henan Prov Peoples Hosp, Dept Pain Management, Zhengzhou, Peoples R China
4.Peoples Liberat Army, Dept Endocrinol, Shenyang, Peoples R China
5.China Med Univ, Hosp 1, Dept Pain Management, Shenyang, Peoples R China
6.So Med Univ, Zhujiang Hosp, Dept Endocrinol, Guangzhou, Guangdong, Peoples R China
7.Peoples Liberat Army, AF Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
8.Peoples Liberat Army, Dept Endocrinol, Shenyang, Peoples R China
9.Harbin Med Coll, Hosp 2, Dept Pain Management, Harbin, Peoples R China
10.Peking Univ, Hosp 1, Cardiovascular Dept, Beijing 100871, Peoples R China
11.Dept Pain Management, Beijing, Peoples R China
12.N China Elect Power Hosp, Dept Pain Management, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yao Peng,Meng Ling-Xin,Ma Jia-Ming,et al. Sustained-Release Oxycodone Tablets for Moderate to Severe Painful Diabetic Peripheral Neuropathy: A Multicenter, Open-Labeled, Postmarketing Clinical Observation[J]. PAIN MEDICINE,2012,13(1):107-114.
APA Yao Peng.,Meng Ling-Xin.,Ma Jia-Ming.,Ding Yuan-Yuan.,Wang Zhi-Bin.,...&Wu Bai-Shan.(2012).Sustained-Release Oxycodone Tablets for Moderate to Severe Painful Diabetic Peripheral Neuropathy: A Multicenter, Open-Labeled, Postmarketing Clinical Observation.PAIN MEDICINE,13(1),107-114.
MLA Yao Peng,et al."Sustained-Release Oxycodone Tablets for Moderate to Severe Painful Diabetic Peripheral Neuropathy: A Multicenter, Open-Labeled, Postmarketing Clinical Observation".PAIN MEDICINE 13.1(2012):107-114.
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