IR@PKUHSC  > 北京大学第二临床医学院  > 妇科
学科主题临床医学
Evaluation of whether serum tumor markers in patients with epithelial ovarian carcinoma change following chemotherapy
Li Xiao-ping; Xu Qi-ying; Wang Jian-liu; Wang Shi-jun; Zhao Yan; Wei Li-hui
关键词epithelial ovarian carcinoma primary serous peritoneal carcinoma tumor marker chemotherapy recurrence
刊名CHINESE MEDICAL JOURNAL
2012-02-05
DOI10.3760/cma.j.issn.0366-6999.2012.03.002
125期:3页:410-415
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]STEM-CELLS ; CANCER ; EXPRESSION ; HETEROGENEITY
英文摘要

Background Phenotypic and genotypic heterogeneity is a known feature of many cancers. Whether serum tumor marker kinds vary and change following chemotherapy is still unclear. The aim of this study was to investigate whether there is a change in the expression of serum tumor markers following chemotherapy, and the potential clinical significance in patients with epithelial ovarian carcinoma (EOC) or primary serous peritoneal carcinoma (PSPC).

Methods Samples were collected before surgery, during chemotherapy and during follow-up for enzyme-linked immunosorbent assay (ELISA)-based evaluation of serum CA-125, CA19-9 and CP2 levels in patients with EOC or PSPC who had received primary debulking surgery followed by adjuvant chemotherapy. In total, 72 patients were examined, including 37 patients with recurrent lesions and 35 patients receiving first-line chemotherapy.

Results In 35 de novo patients, 20% (7/35) demonstrated a significant changed serum tumor marker kinds among whom the patients with mucinous carcinoma (57.1%, 4/7) showed resistance to chemotherapy. In the 37 recurrent patients, 51.4% (19/37) had changed serum tumor markers, of whom 57.9% (11/19) presented with serous carcinoma. There was no significant difference in median progression-free survival or overall survival in patients with drug-sensitive or drug-resistant recurrence in patients with changed tumor marker kinds relative to those with unchanged markers. However, for patients with changed serum tumor markers there was a trend towards prolonged survival compared with the unchanged serum tumor marker group. In the 17 patients with secondary recurrence, 37.5% (6/17) had changed tumor marker levels. The ratios of CA-125/CP2 and CA-125/CA19-9 were significantly different after either chemotherapy or recurrence.

Conclusions Serum tumor marker expression in patients with EOC or PSPC may change after chemotherapy or recurrence, indicating that in addition to the markers that are abnormal before surgery, those markers that are normal should also be monitored during chemotherapy and follow-up. Chin Med J 2012;125(3):410-415

语种英语
WOS记录号WOS:000300749600002
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59167
专题北京大学第二临床医学院_妇科
北京大学第三临床医学院_麻醉科
作者单位Peking Univ, Peoples Hosp, Dept Gynecol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Li Xiao-ping,Xu Qi-ying,Wang Jian-liu,et al. Evaluation of whether serum tumor markers in patients with epithelial ovarian carcinoma change following chemotherapy[J]. CHINESE MEDICAL JOURNAL,2012,125(3):410-415.
APA Li Xiao-ping,Xu Qi-ying,Wang Jian-liu,Wang Shi-jun,Zhao Yan,&Wei Li-hui.(2012).Evaluation of whether serum tumor markers in patients with epithelial ovarian carcinoma change following chemotherapy.CHINESE MEDICAL JOURNAL,125(3),410-415.
MLA Li Xiao-ping,et al."Evaluation of whether serum tumor markers in patients with epithelial ovarian carcinoma change following chemotherapy".CHINESE MEDICAL JOURNAL 125.3(2012):410-415.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li Xiao-ping]的文章
[Xu Qi-ying]的文章
[Wang Jian-liu]的文章
百度学术
百度学术中相似的文章
[Li Xiao-ping]的文章
[Xu Qi-ying]的文章
[Wang Jian-liu]的文章
必应学术
必应学术中相似的文章
[Li Xiao-ping]的文章
[Xu Qi-ying]的文章
[Wang Jian-liu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。