|Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis|
|Yang, Xiao-wei1,2,3,4; Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Zhao, Ming-hui1,2,3,4|
|关键词||anti-C1q autoantibody anti-dsDNA autoantibody autoantibodies lupus nephritis|
|刊名||NEPHROLOGY DIALYSIS TRANSPLANTATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Transplantation ; Urology & Nephrology|
|研究领域[WOS]||Transplantation ; Urology & Nephrology|
|关键词[WOS]||C-REACTIVE PROTEIN ; STRANDED-DNA ; LABORATORY TESTS ; CHINESE PATIENTS ; ERYTHEMATOSUS ; AUTOANTIBODIES ; COHORT ; SERA ; CLASSIFICATION ; IDENTIFICATION|
Although nephritogenic autoantibodies are considered to play a central role in the initiation of lupus nephritis, whether these autoantibodies are associated with renal clinical and pathological activity or renal outcome is still controversial. Here, we investigated the associations of certain serum autoantibodies with renal disease activity and renal outcome in a large cohort of Chinese patients with lupus nephritis.
One hundred and thirty-six Chinese patients with biopsy-proven lupus nephritis and with long-term follow up data were studied. Sera at renal biopsy were tested for a panel of autoantibodies, including anti-nuclear antibodies, anti-double-stranded DNA (anti-dsDNA) antibodies, anti-extractable nuclear antigen antibodies, anti-C-reactive protein antibodies, anti-C1q antibodies, anti-cardiolipin antibodies and anti-2-glycoprotein I antibodies. Associations of these autoantibodies with clinical features, laboratory findings, histopathological data and renal outcomes were further investigated.
Among the various autoantibodies, anti-dsDNA and anti-C1q antibodies were better than other antibodies to evaluate the renal disease activity. Anti-dsDNA antibodies were correlated with higher incidence of leukocyturia (P 0.05), total pathological activity index (AI) score (P 0.05), endocapillary hypercellularity (P 0.05), subendothelial hyaline deposits (P 0.05) and leukocyte infiltration (P 0.05). Anti-C1q antibodies were correlated with leukocyturia (P 0.01), hematuria (P 0.003) and the majority of the histopathological AIs including total AI score (P 0.003), endocapillary hypercellularity (P 0.003), cellular crescents (P 0.05), karyorrhexis/fibrinoid necrosis (P 0.003), subendothelial hyaline deposits (P 0.003) and leukocyte infiltration (P 0.01). Patients with both anti-dsDNA and anti-C1q antibodies had higher renal disease activity and poorer renal outcome (log-rank test: P 0.048) compared with those without the two antibodies. In univariate survival analysis of renal prognosis, neither the presence of anti-C1q nor the presence of anti-dsDNA antibodies was a risk factor of renal survival. However, the combination of the two antibodies predicted renal prognosis (hazard ratio 4.40, 95 confidence interval: 1.26815.269, P 0.02).
Anti-C1q antibodies are more closely correlated with renal disease activity than the other autoantibodies. The combination of anti-C1q and anti-dsDNA autoantibodies indicates higher renal disease activity and predicts poor renal outcome.
|项目编号||2012CB517702 ; 81021004 ; 81100497 ; 7102150|
|资助机构||Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation|
|作者单位||1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China|
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China
4.Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
|Yang, Xiao-wei,Tan, Ying,Yu, Feng,et al. Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,27(9):3552-3559.|
|APA||Yang, Xiao-wei,Tan, Ying,Yu, Feng,&Zhao, Ming-hui.(2012).Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis.NEPHROLOGY DIALYSIS TRANSPLANTATION,27(9),3552-3559.|
|MLA||Yang, Xiao-wei,et al."Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis".NEPHROLOGY DIALYSIS TRANSPLANTATION 27.9(2012):3552-3559.|