北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis
作者: Yang, Xiao-wei1,2,3,4; Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Zhao, Ming-hui1,2,3,4
关键词: anti-C1q autoantibody ; anti-dsDNA autoantibody ; autoantibodies ; lupus nephritis
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2012-09-01
DOI: 10.1093/ndt/gfs179
卷: 27, 期:9, 页:3552-3559
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: C-REACTIVE PROTEIN ; STRANDED-DNA ; LABORATORY TESTS ; CHINESE PATIENTS ; ERYTHEMATOSUS ; AUTOANTIBODIES ; COHORT ; SERA ; CLASSIFICATION ; IDENTIFICATION
英文摘要:

Although nephritogenic autoantibodies are considered to play a central role in the initiation of lupus nephritis, whether these autoantibodies are associated with renal clinical and pathological activity or renal outcome is still controversial. Here, we investigated the associations of certain serum autoantibodies with renal disease activity and renal outcome in a large cohort of Chinese patients with lupus nephritis.

One hundred and thirty-six Chinese patients with biopsy-proven lupus nephritis and with long-term follow up data were studied. Sera at renal biopsy were tested for a panel of autoantibodies, including anti-nuclear antibodies, anti-double-stranded DNA (anti-dsDNA) antibodies, anti-extractable nuclear antigen antibodies, anti-C-reactive protein antibodies, anti-C1q antibodies, anti-cardiolipin antibodies and anti-2-glycoprotein I antibodies. Associations of these autoantibodies with clinical features, laboratory findings, histopathological data and renal outcomes were further investigated.

Among the various autoantibodies, anti-dsDNA and anti-C1q antibodies were better than other antibodies to evaluate the renal disease activity. Anti-dsDNA antibodies were correlated with higher incidence of leukocyturia (P 0.05), total pathological activity index (AI) score (P 0.05), endocapillary hypercellularity (P 0.05), subendothelial hyaline deposits (P 0.05) and leukocyte infiltration (P 0.05). Anti-C1q antibodies were correlated with leukocyturia (P 0.01), hematuria (P 0.003) and the majority of the histopathological AIs including total AI score (P 0.003), endocapillary hypercellularity (P 0.003), cellular crescents (P 0.05), karyorrhexis/fibrinoid necrosis (P 0.003), subendothelial hyaline deposits (P 0.003) and leukocyte infiltration (P 0.01). Patients with both anti-dsDNA and anti-C1q antibodies had higher renal disease activity and poorer renal outcome (log-rank test: P 0.048) compared with those without the two antibodies. In univariate survival analysis of renal prognosis, neither the presence of anti-C1q nor the presence of anti-dsDNA antibodies was a risk factor of renal survival. However, the combination of the two antibodies predicted renal prognosis (hazard ratio 4.40, 95 confidence interval: 1.26815.269, P 0.02).

Anti-C1q antibodies are more closely correlated with renal disease activity than the other autoantibodies. The combination of anti-C1q and anti-dsDNA autoantibodies indicates higher renal disease activity and predicts poor renal outcome.

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81100497 ; 7102150
项目资助者: Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000308244400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59175
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China
4.Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China

Recommended Citation:
Yang, Xiao-wei,Tan, Ying,Yu, Feng,et al. Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,27(9):3552-3559.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Xiao-wei]'s Articles
[Tan, Ying]'s Articles
[Yu, Feng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Xiao-wei]‘s Articles
[Tan, Ying]‘s Articles
[Yu, Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace