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Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis
Yang, Xiao-wei1,2,3,4; Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Zhao, Ming-hui1,2,3,4
关键词anti-C1q autoantibody anti-dsDNA autoantibody autoantibodies lupus nephritis
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2012-09-01
DOI10.1093/ndt/gfs179
27期:9页:3552-3559
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]C-REACTIVE PROTEIN ; STRANDED-DNA ; LABORATORY TESTS ; CHINESE PATIENTS ; ERYTHEMATOSUS ; AUTOANTIBODIES ; COHORT ; SERA ; CLASSIFICATION ; IDENTIFICATION
英文摘要

Although nephritogenic autoantibodies are considered to play a central role in the initiation of lupus nephritis, whether these autoantibodies are associated with renal clinical and pathological activity or renal outcome is still controversial. Here, we investigated the associations of certain serum autoantibodies with renal disease activity and renal outcome in a large cohort of Chinese patients with lupus nephritis.

One hundred and thirty-six Chinese patients with biopsy-proven lupus nephritis and with long-term follow up data were studied. Sera at renal biopsy were tested for a panel of autoantibodies, including anti-nuclear antibodies, anti-double-stranded DNA (anti-dsDNA) antibodies, anti-extractable nuclear antigen antibodies, anti-C-reactive protein antibodies, anti-C1q antibodies, anti-cardiolipin antibodies and anti-2-glycoprotein I antibodies. Associations of these autoantibodies with clinical features, laboratory findings, histopathological data and renal outcomes were further investigated.

Among the various autoantibodies, anti-dsDNA and anti-C1q antibodies were better than other antibodies to evaluate the renal disease activity. Anti-dsDNA antibodies were correlated with higher incidence of leukocyturia (P 0.05), total pathological activity index (AI) score (P 0.05), endocapillary hypercellularity (P 0.05), subendothelial hyaline deposits (P 0.05) and leukocyte infiltration (P 0.05). Anti-C1q antibodies were correlated with leukocyturia (P 0.01), hematuria (P 0.003) and the majority of the histopathological AIs including total AI score (P 0.003), endocapillary hypercellularity (P 0.003), cellular crescents (P 0.05), karyorrhexis/fibrinoid necrosis (P 0.003), subendothelial hyaline deposits (P 0.003) and leukocyte infiltration (P 0.01). Patients with both anti-dsDNA and anti-C1q antibodies had higher renal disease activity and poorer renal outcome (log-rank test: P 0.048) compared with those without the two antibodies. In univariate survival analysis of renal prognosis, neither the presence of anti-C1q nor the presence of anti-dsDNA antibodies was a risk factor of renal survival. However, the combination of the two antibodies predicted renal prognosis (hazard ratio 4.40, 95 confidence interval: 1.26815.269, P 0.02).

Anti-C1q antibodies are more closely correlated with renal disease activity than the other autoantibodies. The combination of anti-C1q and anti-dsDNA autoantibodies indicates higher renal disease activity and predicts poor renal outcome.

语种英语
WOS记录号WOS:000308244400029
项目编号2012CB517702 ; 81021004 ; 81100497 ; 7102150
资助机构Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59175
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China
4.Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
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GB/T 7714
Yang, Xiao-wei,Tan, Ying,Yu, Feng,et al. Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,27(9):3552-3559.
APA Yang, Xiao-wei,Tan, Ying,Yu, Feng,&Zhao, Ming-hui.(2012).Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis.NEPHROLOGY DIALYSIS TRANSPLANTATION,27(9),3552-3559.
MLA Yang, Xiao-wei,et al."Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis".NEPHROLOGY DIALYSIS TRANSPLANTATION 27.9(2012):3552-3559.
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