IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Coexistence of Anti-Glomerular Basement Membrane Antibodies and Anti-Neutrophil Cytoplasmic Antibodies in a Child With Human Leukocyte Antigen Susceptibility and Detailed Antibody Description A Case Report
Xie, Li-jun1,2,3,4,6; Cui, Zhao1,2,3,4,5; Jia, Xiao-yu1,2,3,4; Chen, Zhi; Liu, Xiao-rong5; Zhao, Ming-hui1,2,3,4,7
刊名MEDICINE
2015-07-01
DOI10.1097/MD.0000000000001179
94期:29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Chinese 973 Program ; Natural Science Fund of China ; National Natural Science Fund of China ; Beijing Municipal Science and Technology Commission ; Chinese 973 Program ; Natural Science Fund of China ; National Natural Science Fund of China ; Beijing Municipal Science and Technology Commission
研究领域[WOS]General & Internal Medicine
关键词[WOS]PULMONARY RENAL SYNDROME ; SEQUENTIAL DEVELOPMENT ; GBM ANTIBODIES ; DISEASE ; GLOMERULONEPHRITIS ; AUTOANTIBODIES ; ANCA ; MYELOPEROXIDASE ; VASCULITIS ; SPECIFICITY
英文摘要

Anti-glomerular basement membrane (anti-GBM) disease and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis both could cause rapidly progressive glomerulonephritis. The coexistence of ANCAs and anti-GBM antibodies was known as double positive, which was extremely rare in children. We report a pediatric case with coexistence of ANCAs and anti-GBM antibodies.A 6-year-old girl presented with acute renal failure, hematuria, proteinuria, and oliguria. She was double positive of ANCAs specific to myeloperoxidase, and anti-GBM antibodies. Kidney biopsy confirmed linear immunoglobulin (Ig)G deposit along GBM and 100% of crescent formation in glomeruli; among them 83.3% were cellular crescents. Human leukocyte antigen (HLA) gene typing showed DRB11501, an allele strongly associated with anti-GBM disease, and DRB10405, an independent risk factor for renal failure in patients with ANCA-associated vasculitis. The titer of anti-GBM antibodies was 1:800, and the predominant IgG subclass was IgG1, which was closely related with severe kidney injury and worse outcome. The target antigen of anti-GBM antibodies was restricted on the noncollagen domain 1 of the 3 chain of type IV collagen (3[IV]NC1), with recognitions to both epitopes, E-A (3(17-31)) and E-B (3(127-141)).This is the first reported pediatric case with coexistence of ANCAs and anti-GBM antibodies, in which the HLA typing and immunologic characters of autoantibodies were identified. The findings on this early-onset patient are meaningful for understanding the mechanisms of both anti-GBM disease and ANCA-associated vasculitis.

语种英语
所属项目编号2012CB517702 ; 81321064 ; 81170645 ; 81330020 ; 81370801 ; 81400703 ; Z121107001012052
资助者Chinese 973 Program ; Natural Science Fund of China ; National Natural Science Fund of China ; Beijing Municipal Science and Technology Commission ; Chinese 973 Program ; Natural Science Fund of China ; National Natural Science Fund of China ; Beijing Municipal Science and Technology Commission
WOS记录号WOS:000359921500001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59176
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing, Peoples R China
4.Minist Hlth China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
5.Capital Med Univ, Beijing Childrens Hosp, Dept Nephrol, Beijing 100045, Peoples R China
6.Guangxi Med Univ, Affiliated Hosp 1, Dept Med, Div Renal, Nanning 530021, Guangxi Zhuang, Peoples R China
7.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xie, Li-jun,Cui, Zhao,Jia, Xiao-yu,et al. Coexistence of Anti-Glomerular Basement Membrane Antibodies and Anti-Neutrophil Cytoplasmic Antibodies in a Child With Human Leukocyte Antigen Susceptibility and Detailed Antibody Description A Case Report[J]. MEDICINE,2015,94(29).
APA Xie, Li-jun,Cui, Zhao,Jia, Xiao-yu,Chen, Zhi,Liu, Xiao-rong,&Zhao, Ming-hui.(2015).Coexistence of Anti-Glomerular Basement Membrane Antibodies and Anti-Neutrophil Cytoplasmic Antibodies in a Child With Human Leukocyte Antigen Susceptibility and Detailed Antibody Description A Case Report.MEDICINE,94(29).
MLA Xie, Li-jun,et al."Coexistence of Anti-Glomerular Basement Membrane Antibodies and Anti-Neutrophil Cytoplasmic Antibodies in a Child With Human Leukocyte Antigen Susceptibility and Detailed Antibody Description A Case Report".MEDICINE 94.29(2015).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Xie, Li-jun]'s Articles
[Cui, Zhao]'s Articles
[Jia, Xiao-yu]'s Articles
百度学术
百度学术Similar articles in
[Xie, Li-jun]'s Articles
[Cui, Zhao]'s Articles
[Jia, Xiao-yu]'s Articles
必应学术
必应学术Similar articles in
[Xie, Li-jun]'s Articles
[Cui, Zhao]'s Articles
[Jia, Xiao-yu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.