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学科主题: 临床医学
题名:
Serum antibodies to Helicobacter pylori and the CagA antigen do not explain differences in the prevalence of precancerous gastric lesions in two chinese Populations with contrasting gastric cancer rates
作者: Groves, FD; Perez-Perez, G; Zhang, L; You, WC; Lipsitz, SR; Gail, MH; Fraumeni, JF; Blaser, MJ
刊名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
发表日期: 2002-10-01
卷: 11, 期:10, 页:1091-1094
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: HIGH-RISK ; POSITIVE STRAINS ; 2 COUNTIES ; INFECTION ; STOMACH
英文摘要:

Incidence and mortality rates for gastric cancer in rural People′s Republic of China differ greatly over short distances. In Shandong Province, we studied asymptomatic adult subjects from Bei Duan village (n = 196) in Linqu County (a high-risk area for gastric cancer) and from Shi Huang village (n = 192) in Cangshan County (a low-risk area for gastric cancer). The prevalence of advanced precancerous gastric lesions (APGL) was assessed by microscopic examination of endoscopic stomach biopsies. ELISAs were used to detect serum IgG to Helicobacter pylori whole-cell antigen and to the CagA protein. A logistic regression model was used to quantify the role of the two H. pylori seromarkers in explaining the differences in prevalence of APGL between the two villages after adjusting for age and sex.

The prevalence of APGL was much greater in Bei Duan than in Shi Huang. Although H. pylori seroprevalence by the whole-cell ELISA was similar in the two populations, seroprevalence of CagA was significantly greater in Bei Duan. Although age, sex, and both H. pylori seromarkers were associated with APGL in the logistic regression model, the effect of village of residence remained strong after adjustment for all four covariates. Only a relatively small proportion of the difference in prevalence of APGL between these two rural Chinese populations can be explained by differences in H. pylori or CagA seroprevalence.

语种: 英语
WOS记录号: WOS:000178634100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59177
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Med Univ S Carolina, Dept Biometry & Epidemiol, Charleston, SC 29425 USA
2.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
3.NYU, Sch Med, Dept Internal Med, New York, NY 10016 USA
4.Peking Univ, Beijing Inst Canc Res, Beijing 100034, Peoples R China
5.Peking Univ, Sch Oncol, Beijing 100034, Peoples R China
6.Vet Adm Med Ctr, New York, NY 10010 USA

Recommended Citation:
Groves, FD,Perez-Perez, G,Zhang, L,et al. Serum antibodies to Helicobacter pylori and the CagA antigen do not explain differences in the prevalence of precancerous gastric lesions in two chinese Populations with contrasting gastric cancer rates[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2002,11(10):1091-1094.
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