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Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study
Li, Qiang1; Wang, Yarong1; Zhang, Yi2; Li, Wei1; Yang, Weichuan1; Zhu, Jia1; Wu, Ning1; Chang, Haifeng1; Zheng, Ying1; Qin, Wei2; Zhao, Liyan3; Yuan, Kai2; Liu, Jixin2; Wang, Wei1; Tian, Jie1,2,4
关键词Abstinence Craving Functional magnetic resonance imaging Heroin dependence
刊名BRAIN RESEARCH
2012-08-21
DOI10.1016/j.brainres.2012.06.024
1469页:63-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DRUG-ADDICTION ; REWARD CIRCUITRY ; NEURAL RESPONSES ; DORSAL STRIATUM ; SMOKING CUES ; BRAIN FMRI ; ACTIVATION ; DOPAMINE ; CORTEX ; DEPENDENCE
英文摘要

Craving is an important factor in relapse to drug abuse, and cue-induced craving is an especially powerful form of this construct. Neuroimaging methods have been utilized to study drug cue-induced craving and neural correlates in the human brain. However, very few studies have focused on characterizing craving and the neural responses to heroin-related cues in short-term abstinent heroin-dependent patients. Twenty-four heroin-dependent subjects and 20 demographically matched drug-naive subjects participated in this study. An event-related cue-reactivity paradigm was employed, while changes in blood oxygen level-dependent (BOLD) signals were acquired by functional magnetic resonance imaging (fMRI). The heroin-dependent group reported significantly increased craving following exposure to heroin-related cues. Direct comparison between the two groups showed that brain activation to heroin-related minus neutral cues was significantly greater for the heroin-dependent group in the bilateral nucleus accumbens (NAc), caudate, putamen, amygdala, hippocampus/parahippocampus, midcingulate cortex, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), medial frontal gyrus (MeFG), midbrain, thalamus, left anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and subcallosal gyrus. Changes in craving in the heroin-dependent group correlated positively with brain activation in the bilateral NAc, caudate, right putamen, and left ACC. The abstinence duration correlated positively with brain activation in the left caudate and right parahippocampal gyrus. In conclusion, the cue-reactivity paradigm significantly activated neural responses in the mesolimbic dopamine (DA) system and prefrontal cortex (PFC) and induced increased craving in short-term abstinent heroin-dependent patients. We suggest that these response patterns characterize the high vulnerability of relapse in short-term abstinent heroin-dependent subjects. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000308265100007
项目编号30870685 ; 81071142 ; 81071143 ; 60901064 ; 2008K12-02 ; 2009K01-65 ; 2010K16-03-01 ; 2010K16-03-02
资助机构National Natural Science Foundation of China ; Development Project of Science and Technology of Shaanxi Province
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59178
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China
2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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GB/T 7714
Li, Qiang,Wang, Yarong,Zhang, Yi,et al. Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study[J]. BRAIN RESEARCH,2012,1469:63-72.
APA Li, Qiang.,Wang, Yarong.,Zhang, Yi.,Li, Wei.,Yang, Weichuan.,...&Tian, Jie.(2012).Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study.BRAIN RESEARCH,1469,63-72.
MLA Li, Qiang,et al."Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study".BRAIN RESEARCH 1469(2012):63-72.
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