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IR@PKUHSC  > 北京大学临床肿瘤学院  > 分子肿瘤学研究室  > 期刊论文
学科主题: 临床医学
题名:
Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer
作者: Kang, Bin; Guo, Rui-Fang; Tan, Xiao-Hui; Zhao, Min; Tang, Zhuo-Bin; Lu, You-Yong
关键词: ATM ; gastric cancer ; prognosis ; DHPLC
刊名: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
发表日期: 2008-02-01
DOI: 10.1016/j.mrfmmm.2007.08.013
卷: 638, 期:1-2, 页:17-25
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
关键词[WOS]: ATM-DEPENDENT PHOSPHORYLATION ; DNA-DAMAGE RESPONSE ; CHECKPOINT PATHWAY ; IONIZING-RADIATION ; ACTIVATION ; MUTATIONS ; BREAST ; P53 ; CARCINOMA ; APOPTOSIS
英文摘要:

Many studies have revealed the ATM alterations involved in cancer development and progression. In order to elucidate ATM deficiency in advanced GC and its clinical significance, a total of 20 exons of ATM gene, including frequently reported variations, were screened in 40 advanced primary GC and matched normal tissues using denaturing high performance liquid chromatography (DHPLC) and DNA sequencing analysis. Furthermore, ATM mRNA level was analyzed using Real-time RT-PCR and in situ hybridization, and protein expression and phosphorylation at Ser1981 were measured by immunohistochemical assessment in tissue microarray of GC. Five variants were identified in 6 of 40 cases (15%), but no hot spot of variation was detected. However, decreased expression and phosphorylation of ATM were consistently presented in tumors. In a cohort of 70 GC samples, low level of phosphorylated ATM was significantly correlated with poor differentiation, lymph node metastasis and poor 5-year survival (P < 0.05). These results indicated that ATM phosphorylation status might be a prognostic marker for individual therapy in advanced GC patients. (C) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000253034000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59181
Appears in Collections:北京大学临床肿瘤学院_分子肿瘤学研究室_期刊论文

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作者单位: Peking Univ, Beijing Canc Hosp, Sch Oncol, Mol Oncol Lab, Beijing 100036, Peoples R China

Recommended Citation:
Kang, Bin,Guo, Rui-Fang,Tan, Xiao-Hui,et al. Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2008,638(1-2):17-25.
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