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学科主题临床医学
Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer
Kang, Bin; Guo, Rui-Fang; Tan, Xiao-Hui; Zhao, Min; Tang, Zhuo-Bin; Lu, You-Yong
关键词ATM gastric cancer prognosis DHPLC
刊名MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
2008-02-01
DOI10.1016/j.mrfmmm.2007.08.013
638期:1-2页:17-25
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
关键词[WOS]ATM-DEPENDENT PHOSPHORYLATION ; DNA-DAMAGE RESPONSE ; CHECKPOINT PATHWAY ; IONIZING-RADIATION ; ACTIVATION ; MUTATIONS ; BREAST ; P53 ; CARCINOMA ; APOPTOSIS
英文摘要

Many studies have revealed the ATM alterations involved in cancer development and progression. In order to elucidate ATM deficiency in advanced GC and its clinical significance, a total of 20 exons of ATM gene, including frequently reported variations, were screened in 40 advanced primary GC and matched normal tissues using denaturing high performance liquid chromatography (DHPLC) and DNA sequencing analysis. Furthermore, ATM mRNA level was analyzed using Real-time RT-PCR and in situ hybridization, and protein expression and phosphorylation at Ser1981 were measured by immunohistochemical assessment in tissue microarray of GC. Five variants were identified in 6 of 40 cases (15%), but no hot spot of variation was detected. However, decreased expression and phosphorylation of ATM were consistently presented in tumors. In a cohort of 70 GC samples, low level of phosphorylated ATM was significantly correlated with poor differentiation, lymph node metastasis and poor 5-year survival (P < 0.05). These results indicated that ATM phosphorylation status might be a prognostic marker for individual therapy in advanced GC patients. (C) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000253034000003
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59181
专题北京大学临床肿瘤学院_分子肿瘤学研究室
作者单位Peking Univ, Beijing Canc Hosp, Sch Oncol, Mol Oncol Lab, Beijing 100036, Peoples R China
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Kang, Bin,Guo, Rui-Fang,Tan, Xiao-Hui,et al. Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2008,638(1-2):17-25.
APA Kang, Bin,Guo, Rui-Fang,Tan, Xiao-Hui,Zhao, Min,Tang, Zhuo-Bin,&Lu, You-Yong.(2008).Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,638(1-2),17-25.
MLA Kang, Bin,et al."Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 638.1-2(2008):17-25.
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