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学科主题: 临床医学
题名:
The molecular mechanism and potential role of heat shock-induced p53 protein accumulation
作者: Han, Juqiang1,2; Xu, Xiaojie2; Qin, Hongzhen3; Liu, Anheng4; Fan, Zhongyi2; Kang, Lei2,5; Fu, Jing2; Liu, Jiahong2; Ye, Qinong2
关键词: Heat stress ; p53 ; Heat therapy
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2013-06-01
DOI: 10.1007/s11010-013-1607-9
卷: 378, 期:1-2, 页:161-169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: RADIOFREQUENCY ABLATION ; HEPATOCELLULAR-CARCINOMA ; CELLULAR-RESPONSE ; CELLS ; EXPRESSION ; TUMORS ; STRESS ; GENE ; RADIATION ; APOPTOSIS
英文摘要:

Workers who are exposed to extreme heat or work in hot environments may be at risk of heat stress. Exposure to extreme heat can result in occupational illnesses and injuries. On the other hand, local and regional heat therapy has been used for the treatment of some cancers, such as liver cancer, lung cancer, and kidney cancer. Although heat stress has been shown to induce the accumulation of p53 protein, a key regulator of cell cycle, apoptosis, DNA repair, and autophagy, how it regulates p53 protein accumulation and what the p53 targets are remain unclear. Here, we show that, among various genotoxic stresses, including ionizing radiation (IR) and ultraviolet (UV) radiation, heat stress contributes significantly to increase p53 protein levels in normal liver cells and liver cancer cells. Heat stress did not increase p53 mRNA expression as well as p53 promoter activity. However, heat stress enhanced the half-life of p53 protein. Moreover, heat stress increased the expression of puma and light chain 3 (LC-3), which are associated with the apoptotic and autophagic function of p53, respectively, whereas it did not change the expression of the cell cycle regulators p21, 14-3-3 delta, and GADD45 alpha, suggesting that heat-triggered alteration of p53 selectively modulates the downstream targets of p53. Our study provides a novel mechanism by which heat shock stimulates p53 protein accumulation, which is different from common DNA damages, such as IR and UV, and also provides new molecular basis for heat injuries or heat therapy.

语种: 英语
所属项目编号: 31100604 ; 81101065 ; 30972594 ; 81272913
项目资助者: National Natural Science Foundation
WOS记录号: WOS:000318184100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59183
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Beijing Mil Gen Hosp, Inst Hepatol, Beijing 100700, Peoples R China
2.305 Hosp PLA, Dept Gen Surg, Beijing, Peoples R China
3.307 Hosp PLA, Dept Cardiol, Beijing 100071, Peoples R China
4.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China
5.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China

Recommended Citation:
Han, Juqiang,Xu, Xiaojie,Qin, Hongzhen,et al. The molecular mechanism and potential role of heat shock-induced p53 protein accumulation[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2013,378(1-2):161-169.
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