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学科主题临床医学
Helicobacter pylori infection: an overview in 2013, focus on therapy
Cui Rongli; Zhou Liya
关键词Helicobacter pylori antibiotic resistance prevalence therapy
刊名CHINESE MEDICAL JOURNAL
2014-02-05
DOI10.3760/cma.j.issn.0366-6999.20132708
127期:3页:568-573
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National "Twelfth Five-Year" Plan for Science &amp ; Technology support program plan ; National "Twelfth Five-Year" Plan for Science &amp ; Technology support program plan
研究领域[WOS]General & Internal Medicine
关键词[WOS]PROTON PUMP INHIBITOR ; RANDOMIZED CONTROLLED-TRIAL ; TRIPLE THERAPY ; GASTRIC-CANCER ; ANTIBIOTIC-RESISTANCE ; ANTIMICROBIAL-RESISTANCE ; PATHOLOGICAL-CHANGES ; CONCOMITANT THERAPY ; ERADICATION THERAPY ; PREVALENCE
英文摘要

Objective This article aimed to review the incidence of Helicobacter pylori (H. pylon) infection and its therapy.

Data sources Relevant articles published in English were identified by searching in PubMed from 2000 to 2013, with keywords "H. pylori′. Important references from selected articles were also retrieved from Elsevier, Wiley, EBSCO, and SPRINGER. The Chinese articles published were searched from China National Knowledge Infrastructure (CNKI).

Study selection Articles about "prevalence", "gastric carcinoma", "peptic ulcer", "gastroesophageal reflux disease", "functional dyspepsia", "pathogenic mechanism", "therapy", "eradication rate", "antibiotic resistance", and "gene polymorphisms" were selected.

Results The decreased infection rates of H. pylori could also be linked to the changed disease spectrum, such as the decreased morbidity and recurrence rate of H. pylori-related peptic ulcer, and the increased morbidity of gastroesophageal reflux. Although different treatment regimens have been used for H. pylon infection, the H. pylori eradication rate declined gradually. Due to primary resistance to antibiotics, the gene polymorphism of host and infected strain, and the therapy regimes, H. pylori eradication became even more difficult.

Conclusions The prevalence of H. pylori infection had been decreasing, but the rate of eradication failure has dramatically risen in many countries due to resistance to antibiotic. H. pylori therapy in clinical practice is becoming progressively more difficult.

语种英语
所属项目编号2012BAI06B00
资助者National "Twelfth Five-Year" Plan for Science &amp ; Technology support program plan ; National "Twelfth Five-Year" Plan for Science &amp ; Technology support program plan
WOS记录号WOS:000333498400029
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59184
Collection北京大学第三临床医学院_消化科
作者单位Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Cui Rongli,Zhou Liya. Helicobacter pylori infection: an overview in 2013, focus on therapy[J]. CHINESE MEDICAL JOURNAL,2014,127(3):568-573.
APA Cui Rongli,&Zhou Liya.(2014).Helicobacter pylori infection: an overview in 2013, focus on therapy.CHINESE MEDICAL JOURNAL,127(3),568-573.
MLA Cui Rongli,et al."Helicobacter pylori infection: an overview in 2013, focus on therapy".CHINESE MEDICAL JOURNAL 127.3(2014):568-573.
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