|Helicobacter pylori infection: an overview in 2013, focus on therapy|
|Cui Rongli; Zhou Liya|
|关键词||Helicobacter pylori antibiotic resistance prevalence therapy|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||PROTON PUMP INHIBITOR ; RANDOMIZED CONTROLLED-TRIAL ; TRIPLE THERAPY ; GASTRIC-CANCER ; ANTIBIOTIC-RESISTANCE ; ANTIMICROBIAL-RESISTANCE ; PATHOLOGICAL-CHANGES ; CONCOMITANT THERAPY ; ERADICATION THERAPY ; PREVALENCE|
Objective This article aimed to review the incidence of Helicobacter pylori (H. pylon) infection and its therapy.
Data sources Relevant articles published in English were identified by searching in PubMed from 2000 to 2013, with keywords "H. pylori′. Important references from selected articles were also retrieved from Elsevier, Wiley, EBSCO, and SPRINGER. The Chinese articles published were searched from China National Knowledge Infrastructure (CNKI).
Study selection Articles about "prevalence", "gastric carcinoma", "peptic ulcer", "gastroesophageal reflux disease", "functional dyspepsia", "pathogenic mechanism", "therapy", "eradication rate", "antibiotic resistance", and "gene polymorphisms" were selected.
Results The decreased infection rates of H. pylori could also be linked to the changed disease spectrum, such as the decreased morbidity and recurrence rate of H. pylori-related peptic ulcer, and the increased morbidity of gastroesophageal reflux. Although different treatment regimens have been used for H. pylon infection, the H. pylori eradication rate declined gradually. Due to primary resistance to antibiotics, the gene polymorphism of host and infected strain, and the therapy regimes, H. pylori eradication became even more difficult.
Conclusions The prevalence of H. pylori infection had been decreasing, but the rate of eradication failure has dramatically risen in many countries due to resistance to antibiotic. H. pylori therapy in clinical practice is becoming progressively more difficult.
|资助机构||National "Twelfth Five-Year" Plan for Science & ; Technology support program plan|
|作者单位||Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China|
|Cui Rongli,Zhou Liya. Helicobacter pylori infection: an overview in 2013, focus on therapy[J]. CHINESE MEDICAL JOURNAL,2014,127(3):568-573.|
|APA||Cui Rongli,&Zhou Liya.(2014).Helicobacter pylori infection: an overview in 2013, focus on therapy.CHINESE MEDICAL JOURNAL,127(3),568-573.|
|MLA||Cui Rongli,et al."Helicobacter pylori infection: an overview in 2013, focus on therapy".CHINESE MEDICAL JOURNAL 127.3(2014):568-573.|