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学科主题: 临床医学
题名:
Helicobacter pylori infection: an overview in 2013, focus on therapy
作者: Cui Rongli; Zhou Liya
关键词: Helicobacter pylori ; antibiotic resistance ; prevalence ; therapy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-02-05
DOI: 10.3760/cma.j.issn.0366-6999.20132708
卷: 127, 期:3, 页:568-573
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PROTON PUMP INHIBITOR ; RANDOMIZED CONTROLLED-TRIAL ; TRIPLE THERAPY ; GASTRIC-CANCER ; ANTIBIOTIC-RESISTANCE ; ANTIMICROBIAL-RESISTANCE ; PATHOLOGICAL-CHANGES ; CONCOMITANT THERAPY ; ERADICATION THERAPY ; PREVALENCE
英文摘要:

Objective This article aimed to review the incidence of Helicobacter pylori (H. pylon) infection and its therapy.

Data sources Relevant articles published in English were identified by searching in PubMed from 2000 to 2013, with keywords "H. pylori′. Important references from selected articles were also retrieved from Elsevier, Wiley, EBSCO, and SPRINGER. The Chinese articles published were searched from China National Knowledge Infrastructure (CNKI).

Study selection Articles about "prevalence", "gastric carcinoma", "peptic ulcer", "gastroesophageal reflux disease", "functional dyspepsia", "pathogenic mechanism", "therapy", "eradication rate", "antibiotic resistance", and "gene polymorphisms" were selected.

Results The decreased infection rates of H. pylori could also be linked to the changed disease spectrum, such as the decreased morbidity and recurrence rate of H. pylori-related peptic ulcer, and the increased morbidity of gastroesophageal reflux. Although different treatment regimens have been used for H. pylon infection, the H. pylori eradication rate declined gradually. Due to primary resistance to antibiotics, the gene polymorphism of host and infected strain, and the therapy regimes, H. pylori eradication became even more difficult.

Conclusions The prevalence of H. pylori infection had been decreasing, but the rate of eradication failure has dramatically risen in many countries due to resistance to antibiotic. H. pylori therapy in clinical practice is becoming progressively more difficult.

语种: 英语
所属项目编号: 2012BAI06B00
项目资助者: National "Twelfth Five-Year" Plan for Science &amp ; Technology support program plan
WOS记录号: WOS:000333498400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59184
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China

Recommended Citation:
Cui Rongli,Zhou Liya. Helicobacter pylori infection: an overview in 2013, focus on therapy[J]. CHINESE MEDICAL JOURNAL,2014,127(3):568-573.
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