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Rapid downregulation of programmed death-1 and interferon-gamma-inducible protein-10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B
Hou, F. -Q.; Wu, X. -J.; Wang, Y.; Chen, J.; Liu, Y. -Z.; Ren, Y. -Y.; Song, G.; Ding, Y. -P.; Yu, M.; Wang, G. -Q.
关键词hepatitis B virus telbivudine virological response
刊名JOURNAL OF VIRAL HEPATITIS
2013-04-01
DOI10.1111/jvh.12060
suppl.1期:SI页:18-26
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]CD8(+) T-CELLS ; DENDRITIC CELLS ; PD-1 EXPRESSION ; MESSENGER-RNA ; INFECTION ; ACTIVATION ; CHEMOKINE ; FAMILY ; LIVER ; IMMUNOTHERAPY
英文摘要

The dynamics of programmed death-1 (PD-1) as well as cytokine/chemokine expression and its correlation with virological response in patients with chronic hepatitis B (CHB) is unclear. This study was conducted in 29 treatment-naivepatients undergoing telbivudine treatment for 52weeks. The results showed that PD-1 expression on both CD4+ and CD8+ T cells was positively correlated with hepatitis B virus (HBV) DNA levels (r=0.621, P<0.0001; r=0.548, P=0.002, respectively), and in virological responders, this decrease was directly correlated with a decrease in HBV DNA levels (r=0.664, P=0.002; r=0.572, P=0.01, respectively). Furthermore, at the end of 52weeks, in virological responders, the decreased rate in the frequency of PD-1+ CD8+ T cells was significantly higher than in non-virological responders (58.3% vs 25.7%, P=0.001), and at weeks 24 and 52, in virological responders, PD-1 expression on CD4+ and CD8+ T cells was lower than in non-virological responders (P=0.01 and P=0.035; P<0.0001 and P<0.0001, respectively). In 34 cytokines/chemokines detected in serum, IP-10 expression was positively correlated with viral load, level of ALT and PD-1 expression on CD8+ and CD4+ T cells at baseline (r=0.36, P=0.055, r=0.635, P<0.0001, r=0.414, P=0.026, and r=0.402, P=0.030, respectively). Moreover, the decrease in IP-10 in serum directly correlated with a decrease in ALT levels (r=0.751, P<0.0001). At weeks 24 and 25, IP-10 expression was significantly lower than baseline in virological responders (both P=0.005); however, this was not observed in nonresponders. Based on the above findings, PD-1 and IP-10 may be used as predictors for virological response, and blockade of their pathway may improve the outcome of patients with CHB.

语种英语
WOS记录号WOS:000315822400005
项目编号30771905
资助机构National Natural Science Foundation of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59185
专题北京大学第一临床医学院_感染疾病科
北京大学第一临床医学院_泌尿外科
作者单位Peking Univ, Hosp 1, Ctr Liver Dis, Dept Infect Dis, Beijing 10034, Peoples R China
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Hou, F. -Q.,Wu, X. -J.,Wang, Y.,et al. Rapid downregulation of programmed death-1 and interferon-gamma-inducible protein-10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B[J]. JOURNAL OF VIRAL HEPATITIS,2013,suppl.1(SI):18-26.
APA Hou, F. -Q..,Wu, X. -J..,Wang, Y..,Chen, J..,Liu, Y. -Z..,...&Wang, G. -Q..(2013).Rapid downregulation of programmed death-1 and interferon-gamma-inducible protein-10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B.JOURNAL OF VIRAL HEPATITIS,suppl.1(SI),18-26.
MLA Hou, F. -Q.,et al."Rapid downregulation of programmed death-1 and interferon-gamma-inducible protein-10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B".JOURNAL OF VIRAL HEPATITIS suppl.1.SI(2013):18-26.
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