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学科主题: 临床医学
题名:
Rapid downregulation of programmed death-1 and interferon-gamma-inducible protein-10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B
作者: Hou, F. -Q.; Wu, X. -J.; Wang, Y.; Chen, J.; Liu, Y. -Z.; Ren, Y. -Y.; Song, G.; Ding, Y. -P.; Yu, M.; Wang, G. -Q.
关键词: hepatitis B virus ; telbivudine ; virological response
刊名: JOURNAL OF VIRAL HEPATITIS
发表日期: 2013-04-01
DOI: 10.1111/jvh.12060
卷: suppl.1, 期:SI, 页:18-26
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]: CD8(+) T-CELLS ; DENDRITIC CELLS ; PD-1 EXPRESSION ; MESSENGER-RNA ; INFECTION ; ACTIVATION ; CHEMOKINE ; FAMILY ; LIVER ; IMMUNOTHERAPY
英文摘要:

The dynamics of programmed death-1 (PD-1) as well as cytokine/chemokine expression and its correlation with virological response in patients with chronic hepatitis B (CHB) is unclear. This study was conducted in 29 treatment-naivepatients undergoing telbivudine treatment for 52weeks. The results showed that PD-1 expression on both CD4+ and CD8+ T cells was positively correlated with hepatitis B virus (HBV) DNA levels (r=0.621, P<0.0001; r=0.548, P=0.002, respectively), and in virological responders, this decrease was directly correlated with a decrease in HBV DNA levels (r=0.664, P=0.002; r=0.572, P=0.01, respectively). Furthermore, at the end of 52weeks, in virological responders, the decreased rate in the frequency of PD-1+ CD8+ T cells was significantly higher than in non-virological responders (58.3% vs 25.7%, P=0.001), and at weeks 24 and 52, in virological responders, PD-1 expression on CD4+ and CD8+ T cells was lower than in non-virological responders (P=0.01 and P=0.035; P<0.0001 and P<0.0001, respectively). In 34 cytokines/chemokines detected in serum, IP-10 expression was positively correlated with viral load, level of ALT and PD-1 expression on CD8+ and CD4+ T cells at baseline (r=0.36, P=0.055, r=0.635, P<0.0001, r=0.414, P=0.026, and r=0.402, P=0.030, respectively). Moreover, the decrease in IP-10 in serum directly correlated with a decrease in ALT levels (r=0.751, P<0.0001). At weeks 24 and 25, IP-10 expression was significantly lower than baseline in virological responders (both P=0.005); however, this was not observed in nonresponders. Based on the above findings, PD-1 and IP-10 may be used as predictors for virological response, and blockade of their pathway may improve the outcome of patients with CHB.

语种: 英语
所属项目编号: 30771905
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000315822400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59185
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Ctr Liver Dis, Dept Infect Dis, Beijing 10034, Peoples R China

Recommended Citation:
Hou, F. -Q.,Wu, X. -J.,Wang, Y.,et al. Rapid downregulation of programmed death-1 and interferon-gamma-inducible protein-10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B[J]. JOURNAL OF VIRAL HEPATITIS,2013,suppl.1(SI):18-26.
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