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学科主题: 临床医学
题名:
Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes
作者: Zhao, Yi1,2; Zhang, Cheng-Feng1,3; Rossiter, Heidemarie1; Eckhart, Leopold1; Koenig, Ulrich1; Karner, Susanne1; Mildner, Michael1; Bochkov, Valery N.4; Tschachler, Erwin1; Gruber, Florian1
刊名: JOURNAL OF INVESTIGATIVE DERMATOLOGY
发表日期: 2013-06-01
DOI: 10.1038/jid.2013.26
卷: 133, 期:6, 页:1629-1637
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: TRANSCRIPTION FACTOR NRF2 ; LIPID-PEROXIDATION ; HUMAN SKIN ; STRESS-RESPONSE ; DERMAL FIBROBLASTS ; IN-VIVO ; DEGRADATION ; IRRADIATION ; P62/SQSTM1 ; IDENTIFICATION
英文摘要:

The skin is exposed to environmental insults such as UV light that cause oxidative damage to macromolecules. A centerpiece in the defense against oxidative stress is the Nrf2 (nuclear factor (erythroid-derived-2)-like 2)-mediated transcriptional upregulation of antioxidant and detoxifying enzymes and the removal of oxidatively damaged material. Autophagy has an important role in the intracellular degradation of damaged proteins and entire organelles, but its role in the epidermis has remained elusive. Here, we show that both UVA and UVA-oxidized phospholipids induced autophagy in epidermal keratinocytes. Oxidative stressors induced massive accumulation of high-molecular-weight protein aggregates containing the autophagy adaptor protein p62/SQSTM1 in autophagy-deficient (autophagy-related 7 (ATG7) negative) keratinocytes. Strikingly, even in the absence of exogenous stress, the expression of Nrf2-dependent genes was elevated in autophagy-deficient keratinocytes. Furthermore, we show that autophagy-deficient cells contained significantly elevated levels of reactive oxidized phospholipids. Thus, our data demonstrate that autophagy is crucial for both the degradation of proteins and lipids modified by environmental UV stress and for limiting Nrf2 activity in keratinocytes. Lipids that promote inflammation and tissue damage because of their reactivity and signaling functions are commonly observed in aged and diseased skin, and thus targeting autophagy may be a promising strategy to counteract the damage promoted by excessive lipid oxidation.

语种: 英语
所属项目编号: S10713-B13
项目资助者: Centre de Recherche et d&prime ; Investigations Epidermiques et Sensorielles de CHANEL (CE.R.I.E.S, Neuilly, France) ; Austrian Science Fund (FWF)
WOS记录号: WOS:000319121500029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59187
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Med Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria
2.Med Univ Vienna, Dept Vasc Biol, Vienna, Austria
3.Peking Univ, Dept Dermatol & Venereol, Hosp 1, Beijing 100871, Peoples R China
4.Fu Dan Univ, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China

Recommended Citation:
Zhao, Yi,Zhang, Cheng-Feng,Rossiter, Heidemarie,et al. Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY,2013,133(6):1629-1637.
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