IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes
Zhao, Yi1,2; Zhang, Cheng-Feng1,3; Rossiter, Heidemarie1; Eckhart, Leopold1; Koenig, Ulrich1; Karner, Susanne1; Mildner, Michael1; Bochkov, Valery N.4; Tschachler, Erwin1; Gruber, Florian1
刊名JOURNAL OF INVESTIGATIVE DERMATOLOGY
2013-06-01
DOI10.1038/jid.2013.26
133期:6页:1629-1637
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]TRANSCRIPTION FACTOR NRF2 ; LIPID-PEROXIDATION ; HUMAN SKIN ; STRESS-RESPONSE ; DERMAL FIBROBLASTS ; IN-VIVO ; DEGRADATION ; IRRADIATION ; P62/SQSTM1 ; IDENTIFICATION
英文摘要

The skin is exposed to environmental insults such as UV light that cause oxidative damage to macromolecules. A centerpiece in the defense against oxidative stress is the Nrf2 (nuclear factor (erythroid-derived-2)-like 2)-mediated transcriptional upregulation of antioxidant and detoxifying enzymes and the removal of oxidatively damaged material. Autophagy has an important role in the intracellular degradation of damaged proteins and entire organelles, but its role in the epidermis has remained elusive. Here, we show that both UVA and UVA-oxidized phospholipids induced autophagy in epidermal keratinocytes. Oxidative stressors induced massive accumulation of high-molecular-weight protein aggregates containing the autophagy adaptor protein p62/SQSTM1 in autophagy-deficient (autophagy-related 7 (ATG7) negative) keratinocytes. Strikingly, even in the absence of exogenous stress, the expression of Nrf2-dependent genes was elevated in autophagy-deficient keratinocytes. Furthermore, we show that autophagy-deficient cells contained significantly elevated levels of reactive oxidized phospholipids. Thus, our data demonstrate that autophagy is crucial for both the degradation of proteins and lipids modified by environmental UV stress and for limiting Nrf2 activity in keratinocytes. Lipids that promote inflammation and tissue damage because of their reactivity and signaling functions are commonly observed in aged and diseased skin, and thus targeting autophagy may be a promising strategy to counteract the damage promoted by excessive lipid oxidation.

语种英语
WOS记录号WOS:000319121500029
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59187
专题北京大学第一临床医学院
作者单位1.Med Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria
2.Med Univ Vienna, Dept Vasc Biol, Vienna, Austria
3.Peking Univ, Dept Dermatol & Venereol, Hosp 1, Beijing 100871, Peoples R China
4.Fu Dan Univ, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China
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GB/T 7714
Zhao, Yi,Zhang, Cheng-Feng,Rossiter, Heidemarie,et al. Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY,2013,133(6):1629-1637.
APA Zhao, Yi.,Zhang, Cheng-Feng.,Rossiter, Heidemarie.,Eckhart, Leopold.,Koenig, Ulrich.,...&Gruber, Florian.(2013).Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes.JOURNAL OF INVESTIGATIVE DERMATOLOGY,133(6),1629-1637.
MLA Zhao, Yi,et al."Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes".JOURNAL OF INVESTIGATIVE DERMATOLOGY 133.6(2013):1629-1637.
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