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学科主题: 口腔医学
题名:
Oral manifestation of chronic mucocutaneous candidiasis: seven case reports
作者: Liu, Xiaosong; Hua, Hong
关键词: Candida ; chronic mucocutaneous candidiasis ; clinicopathology ; oral manifestation ; oral mucosa
刊名: JOURNAL OF ORAL PATHOLOGY & MEDICINE
发表日期: 2007-10-01
DOI: 10.1111/j.1600-0714.2007.00572.x
卷: 36, 期:9, 页:528-532
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Pathology
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Pathology
关键词[WOS]: DISEASE ; GENE
英文摘要:

BACKGROUND: Chronic mucocutaneous candidiasis (CMC) is a rare disorder characterized by persistent or recurrent candidal infections of the skin, nails and mucous membranes or by a variable combination of endocrine failure as well as immunodeficiency. Oral clinicopathological features of CMC have seldom been described in detail.

METHODS: Seven patients with CMC were reported in the study. The clinical and histological findings, etiological Candida species, immunological evaluation, and therapeutic pattern of oral lesions, were analyzed.

RESULTS: Long-standing whitish hyperplastic and nodule-like lesions with exaggerated deep fissure were the typical and characteristic oral manifestations presented by all patients. The tongue was the most common site affected. Histologically, no obvious distinction was found between CMC and other forms of candidal infection. Abnormal proportions of T-lymphocyte subsets and positive titers of autoantibody were observed in three subjects (42.9%) and one patient (14.3%) respectively. Meanwhile, four subjects (57.1%) showed decreased albumin and increased globulin, three cases (42.9%) had high levels of ESR. But no iron deficiency was found. Candida albicans was the microorganism isolated from these patients.

CONCLUSIONS: Multiple and widespread candidal infectious lesions can be observed on the oral cavity of CMC patients. Hyperplastic and nodule-like lesion with irremovable whitish patches and deep fissure are the most common oral manifestations of these patients. Dentists, otolaryngologists and pediatricians should be familiar with the clinical appearances of CMC to make an accurate diagnosis. Potential systemic disorders should be concerned to avoid the reoccurrence of oral candidiasis.

语种: 英语
WOS记录号: WOS:000249452100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59188
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Sch Hosp Stomatol, Dept Oral Med, Beijing 100081, Peoples R China

Recommended Citation:
Liu, Xiaosong,Hua, Hong. Oral manifestation of chronic mucocutaneous candidiasis: seven case reports[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE,2007,36(9):528-532.
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