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The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats
Liang, JH; Chen, F; Krstew, E; Cowen, MS; Carroll, FY; Crawford, D; Beart, PM; Lawrence, AJ
关键词CGP7930 allosteric modulator GABA(B) receptor baclofen alcohol operant responding
刊名NEUROPHARMACOLOGY
2006-04-01
DOI10.1016/j.neuropharm.2005.11.011
50期:5页:632-639
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]WITHDRAWAL SYNDROME ; ACID(B) RECEPTORS ; DRINKING BEHAVIOR ; SUPPRESSION ; MICE ; COMBINATION ; ACQUISITION ; CONSUMPTION ; MECHANISMS ; NALTREXONE
英文摘要

GABA systems have been implicated as targets for ethanol at the cellular, molecular and behavioural level. The present study was designed to further examine the potential of the GABA(B) receptor as a target for regulating operant alcohol responding. Given that the prototypic agonist, baclofen, reduces the self-administration of alcohol, we hypothesized that the GABA(B) receptor allosteric modulator, CGP7930, might have similar actions but a reduced side-effect profile. In this context, inbred alcohol-prefening (iP) rats were trained to respond for 10% v/v ethanol in a fixed ratio paradigm; all drug testing was performed under an FR3 schedule. Both baclofen and CGP7930 independently reduced voluntary responding for 10% ethanol in a dose-related manner. Neither drug impacted upon responding for water. A combination of subthreshold doses of baclofen and CGP7930 was also able to reduce operant responding for ethanol, suggesting that CGP7930 is indeed acting to facilitate GABA(B) receptor-mediated signalling in this paradigm. These data demonstrate the potential of positive allosteric modulators of metabotropic GABA(B) receptors to regulate alcohol responding. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000236914300013
引用统计
被引频次:87[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59190
专题中国药物依赖性研究所
作者单位1.Tocris Cookson Ltd, Avonmouth BS11 8TA, England
2.Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, Australia
3.Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Brain Injury & Repair Grp, Parkville, Vic 3010, Australia
4.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100871, Peoples R China
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GB/T 7714
Liang, JH,Chen, F,Krstew, E,et al. The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats[J]. NEUROPHARMACOLOGY,2006,50(5):632-639.
APA Liang, JH.,Chen, F.,Krstew, E.,Cowen, MS.,Carroll, FY.,...&Lawrence, AJ.(2006).The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats.NEUROPHARMACOLOGY,50(5),632-639.
MLA Liang, JH,et al."The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats".NEUROPHARMACOLOGY 50.5(2006):632-639.
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