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学科主题: 药物依赖
题名:
The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats
作者: Liang, JH; Chen, F; Krstew, E; Cowen, MS; Carroll, FY; Crawford, D; Beart, PM; Lawrence, AJ
关键词: CGP7930 ; allosteric modulator ; GABA(B) receptor ; baclofen alcohol ; operant responding
刊名: NEUROPHARMACOLOGY
发表日期: 2006-04-01
DOI: 10.1016/j.neuropharm.2005.11.011
卷: 50, 期:5, 页:632-639
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: WITHDRAWAL SYNDROME ; ACID(B) RECEPTORS ; DRINKING BEHAVIOR ; SUPPRESSION ; MICE ; COMBINATION ; ACQUISITION ; CONSUMPTION ; MECHANISMS ; NALTREXONE
英文摘要:

GABA systems have been implicated as targets for ethanol at the cellular, molecular and behavioural level. The present study was designed to further examine the potential of the GABA(B) receptor as a target for regulating operant alcohol responding. Given that the prototypic agonist, baclofen, reduces the self-administration of alcohol, we hypothesized that the GABA(B) receptor allosteric modulator, CGP7930, might have similar actions but a reduced side-effect profile. In this context, inbred alcohol-prefening (iP) rats were trained to respond for 10% v/v ethanol in a fixed ratio paradigm; all drug testing was performed under an FR3 schedule. Both baclofen and CGP7930 independently reduced voluntary responding for 10% ethanol in a dose-related manner. Neither drug impacted upon responding for water. A combination of subthreshold doses of baclofen and CGP7930 was also able to reduce operant responding for ethanol, suggesting that CGP7930 is indeed acting to facilitate GABA(B) receptor-mediated signalling in this paradigm. These data demonstrate the potential of positive allosteric modulators of metabotropic GABA(B) receptors to regulate alcohol responding. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000236914300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59190
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Tocris Cookson Ltd, Avonmouth BS11 8TA, England
2.Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, Australia
3.Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Brain Injury & Repair Grp, Parkville, Vic 3010, Australia
4.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100871, Peoples R China

Recommended Citation:
Liang, JH,Chen, F,Krstew, E,et al. The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats[J]. NEUROPHARMACOLOGY,2006,50(5):632-639.
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