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学科主题: 临床医学
题名:
SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapy
作者: Yang, Ruijie1; Wang, Junjie1; Xu, Shouping2; Li, Hua3
关键词: Endometrial cancer ; Helical tomotherapy ; Intensity-modulated radiation therapy ; Volumetric modulated arc therapy
刊名: BMC CANCER
发表日期: 2013-11-01
DOI: 10.1186/1471-2407-13-515
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: 3-DIMENSIONAL CONFORMAL RADIOTHERAPY ; WHOLE PELVIC RADIOTHERAPY ; CERVICAL-CANCER ; GYNECOLOGIC MALIGNANCIES ; PROSTATE-CANCER ; BONE-MARROW ; IMRT ; DELIVERY ; TUMORS ; WOMEN
英文摘要:

Background: The purpose of the present study was to investigate the feasibility of using volumetric modulated arc therapy with SmartArc (VMAT-S) to achieve radiation delivery efficiency higher than that of intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) when treating endometrial cancer, while maintaining plan quality.

Methods: Nine patients with endometrial cancer were retrospectively studied. Three plans per patient were generated for VMAT-S, IMRT and HT. The dose distributions for the planning target volume (PTV), organs at risk (OARs) and normal tissue were compared. The monitor units (MUs) and treatment delivery time were also evaluated.

Results: The average homogeneity index was 1.06, 1.10 and 1.07 for the VMAT-S, IMRT and HT plans, respectively. The V-40 for the rectum, bladder and pelvis bone decreased by 9.0%, 3.0% and 3.0%, respectively, in the VMAT-S plan relative to the IMRT plan. The target coverage and sparing of OARs were comparable between the VMAT-S and HT plans. The average MU was 823, 1105 and 8403 for VMAT-S, IMRT and HT, respectively; the average delivery time was 2.6, 8.6 and 9.5 minutes, respectively.

Conclusions: For endometrial cancer, the VMAT-S plan provided comparable quality with significantly shorter delivery time and fewer MUs than with the IMRT and HT plans. In addition, more homogeneous PTV coverage and superior sparing of OARs in the medium to high dose region were observed in the VMAT-S relative to the IMRT plan.

语种: 英语
所属项目编号: 81071237
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000329026400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59198
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100871, Peoples R China
2.Peoples Liberat Army, Gen Hosp, Dept Radiat Oncol, Beijing, Peoples R China
3.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Ruijie,Wang, Junjie,Xu, Shouping,et al. SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapy[J]. BMC CANCER,2013,13.
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