北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科  > 期刊论文
学科主题: 临床医学
题名:
Personalized targeted therapy for esophageal squamous cell carcinoma
作者: Kang, Xiaozheng1; Chen, Keneng1; Li, Yicheng2; Li, Jianying3; D′ Amico, Thomas A.4; Chen, Xiaoxin2,5
关键词: Cancer heterogeneity ; Cultured tumor cells ; Driver mutation ; Drug side effects ; Esophageal squamous cell carcinoma ; Exceptional responder ; High-throughput nucleotide sequencing ; Neoplasm drug resistance ; Personalized medicine ; Xenograft model
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2015-07-07
DOI: 10.3748/wjg.v21.i25.7648
卷: 21, 期:25, 页:7648-7658
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PATHWAY-BASED CLASSIFICATION ; CANCER DRIVER GENES ; COLORECTAL-CANCER ; ACQUIRED-RESISTANCE ; BREAST-CANCER ; MOUSE MODELS ; LUNG ADENOCARCINOMAS ; DRUG DEVELOPMENT ; LYMPH-NODE ; MUTATIONS
英文摘要:

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

语种: 英语
所属项目编号: 2009-2-17 ; 7102029 ; 2007-1023 ; 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003 ; NIH/NCI U54 CA156735
项目资助者: Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Fund ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China
WOS记录号: WOS:000357584700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59200
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Euclados Bioinformat Solut LLC, Cary, NC 27519 USA
2.Duke Univ, Med Ctr, Div Thorac Surg, Durham, NC 27705 USA
3.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
4.N Carolina Cent Univ, Julius L Chambers Biomed Biotechnol Res Inst, Canc Res Program, Durham, NC 27707 USA
5.Univ N Carolina, Ctr Esophageal Dis & Swallowing, Dept Med, Div Gastroenterol & Hepatol, Chapel Hill, NC 27519 USA

Recommended Citation:
Kang, Xiaozheng,Chen, Keneng,Li, Yicheng,et al. Personalized targeted therapy for esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2015,21(25):7648-7658.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Kang, Xiaozheng]'s Articles
[Chen, Keneng]'s Articles
[Li, Yicheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Kang, Xiaozheng]‘s Articles
[Chen, Keneng]‘s Articles
[Li, Yicheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace