IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科
学科主题临床医学
Personalized targeted therapy for esophageal squamous cell carcinoma
Kang, Xiaozheng1; Chen, Keneng1; Li, Yicheng2; Li, Jianying3; D′ Amico, Thomas A.4; Chen, Xiaoxin2,5
关键词Cancer heterogeneity Cultured tumor cells Driver mutation Drug side effects Esophageal squamous cell carcinoma Exceptional responder High-throughput nucleotide sequencing Neoplasm drug resistance Personalized medicine Xenograft model
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2015-07-07
DOI10.3748/wjg.v21.i25.7648
21期:25页:7648-7658
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PATHWAY-BASED CLASSIFICATION ; CANCER DRIVER GENES ; COLORECTAL-CANCER ; ACQUIRED-RESISTANCE ; BREAST-CANCER ; MOUSE MODELS ; LUNG ADENOCARCINOMAS ; DRUG DEVELOPMENT ; LYMPH-NODE ; MUTATIONS
英文摘要

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

语种英语
WOS记录号WOS:000357584700004
项目编号2009-2-17 ; 7102029 ; 2007-1023 ; 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003 ; NIH/NCI U54 CA156735
资助机构Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Fund ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59200
专题北京大学临床肿瘤学院_胸外科
作者单位1.Euclados Bioinformat Solut LLC, Cary, NC 27519 USA
2.Duke Univ, Med Ctr, Div Thorac Surg, Durham, NC 27705 USA
3.Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
4.N Carolina Cent Univ, Julius L Chambers Biomed Biotechnol Res Inst, Canc Res Program, Durham, NC 27707 USA
5.Univ N Carolina, Ctr Esophageal Dis & Swallowing, Dept Med, Div Gastroenterol & Hepatol, Chapel Hill, NC 27519 USA
推荐引用方式
GB/T 7714
Kang, Xiaozheng,Chen, Keneng,Li, Yicheng,et al. Personalized targeted therapy for esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2015,21(25):7648-7658.
APA Kang, Xiaozheng.,Chen, Keneng.,Li, Yicheng.,Li, Jianying.,D&prime.,...&Chen, Xiaoxin.(2015).Personalized targeted therapy for esophageal squamous cell carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,21(25),7648-7658.
MLA Kang, Xiaozheng,et al."Personalized targeted therapy for esophageal squamous cell carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 21.25(2015):7648-7658.
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