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学科主题临床医学
Changing pattern of adenocarcinoma of the esophagogastric junction in recent 10 years: experience at a large tertiary, medical center in China
Wang, Kun1; Yang, Chang-qing1; Duan, Li-ping1; Yang, Xue-song1; Xia, Zhi-wei1; Cui, Rong-li1; Jin, Zhu1; McNutt, Michael2
关键词adenocarcinoma of the esophagogastric junction changing pattern reflux esophagitis
刊名TUMORI
2012-09-01
98期:5页:568-574
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HELICOBACTER-PYLORI INFECTION ; GASTROESOPHAGEAL JUNCTION ; ESOPHAGEAL CANCER ; GASTRIC CARDIA ; INTESTINAL METAPLASIA ; REFLUX ESOPHAGITIS ; RISK ; DYSPLASIA ; INFLAMMATION ; METAANALYSIS
英文摘要

Aims and background. To investigate the changing pattern of adenocarcinoma of the esophagogastric junction subtypes and its time trend relationship with that of reflux esophagitis over 10 years at a tertiary medical center in China.

Methods and study design. The medical records of all patients who underwent gastroscopy from 2000 to 2009 were reviewed. Subtypes of adenocarcinoma of the esophagogastric junction according to Siewert′s classification, gastric non-cardiac adenocarcinoma, esophageal squamous cell carcinoma, reflux esophagitis and Helicobacter pylori infection were diagnosed according to the results of gastroscopy and mucosal histopathology. All the patients were divided into three cohorts (cohort A [2000-2003], cohort B [2004-2006]), cohort C [2007-2009]), and the proportion of adenocarcinoma of the esophagogastric junction and its subtypes in all upper gastrointestinal tumors (adenocarcinoma of the esophagogastric junction, gastric non-cardiac adenocarcinoma and esophageal squamous cell carcinoma) in each cohort were compared. The annual percentages of adenocarcinoma of the esophagogastric junction, reflux esophagitis and H pylori in all patients were also compared.

Results. 70,073 patients (cohort A, n = 20298, cohort B, n = 20443, cohort C, n = 29332) who underwent gastroscopy were reviewed. Totally there were 279 patients with adenocarcinoma of the esophagogastric junction (0.398%, M:F = 5.6:1), 794 gastric non-cardiac adenocarcinoma patients (1.133%, M:F = 2:1), 366 esophageal squamous cell carcinoma patients (0.522%, M:F = 3.4:1) and 4681 reflux esophagitis patients. Among the three subtypes of adenocarcinoma of the esophagogastric junction, only type I adenocarcinoma of the esophagogastric junction in upper GI tumors exhibited increasing trend over time (1.86%, 3.39% and 4.94% for cohort A, B and C, respectively, P = 0.009). According to the WHO classification of histological types, the tubular types of adenocarcinoma of the esophagogastric junction have decreased (P = 0.008), whereas papillary type (P = 0.001) increased. The annual detection rate of type I adenocarcinoma of the esophagogastric junction appeared to be positively correlated with reflux esophagitis (r = 0.846, P = 0.002) and negatively with H pylori infection (r = -0.785, P = 0.007) in time trend.

Conclusions. Over a recent 10-year period, the three subtypes of adenocarcinoma of the esophagogastric junction showed different changing trends, suggesting heterogeneous characteristics of the three Siewert types of adenocarcinoma of the esophagogastric junction.

语种英语
WOS记录号WOS:000312431200005
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59202
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pathol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Kun,Yang, Chang-qing,Duan, Li-ping,et al. Changing pattern of adenocarcinoma of the esophagogastric junction in recent 10 years: experience at a large tertiary, medical center in China[J]. TUMORI,2012,98(5):568-574.
APA Wang, Kun.,Yang, Chang-qing.,Duan, Li-ping.,Yang, Xue-song.,Xia, Zhi-wei.,...&McNutt, Michael.(2012).Changing pattern of adenocarcinoma of the esophagogastric junction in recent 10 years: experience at a large tertiary, medical center in China.TUMORI,98(5),568-574.
MLA Wang, Kun,et al."Changing pattern of adenocarcinoma of the esophagogastric junction in recent 10 years: experience at a large tertiary, medical center in China".TUMORI 98.5(2012):568-574.
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