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Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia Nine Years of Experience at a Single Center
Wang, Yu; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Zhang, Xiao-Hui; Han, Wei; Chen, Huan; Chen, Yu-Hong; Wang, Feng-Rong; Wang, Jing-Zhi; Sun, Yu-Qian; Huang, Xiao-Jun
关键词hematopoietic stem cell transplantation allogeneic human leukocyte antigen mismatched haploidentical
刊名CANCER
2013-03-01
DOI10.1002/cncr.27761
119期:5页:978-985
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; DONOR LYMPHOCYTE INFUSION ; HEMATOLOGIC MALIGNANCIES ; MATERNAL ANTIGENS ; MYELOID-LEUKEMIA ; SIBLING DONOR ; HIGH-RISK ; RELAPSE ; TOLERANCE
英文摘要

BACKGROUND: Many patients who require allogeneic hematopoietic stem cell transplantation (allo-HSCT) lack a human leukocyte antigen (HLA)-matched donor. Recently, a new strategy was developed for HLA-mismatched/haploidentical transplantation from family donors without in vitro T cell depletion (TCD). METHODS: Over the past 9 years, 756 patients underwent haploidentical transplantation using a protocol developed by the authors, which combines granulocyte-colony stimulating factorprimed bone marrow (G-BM) and peripheral blood stem cells without in vitro TCD. The long-term outcome with this treatment modality was reported, and a risk-factor analysis was provided. RESULTS: Of these patients, 752 (99%) achieved sustained, full donor chimerism. The incidence of grades 2 through 4 acute graft-versus-host disease (GVHD) was 43%, and the 2-year cumulative incidence of total chronic GVHD was 53%. The 3-year cumulative incidence of nonrelapse mortality was 18%. The 2-year cumulative incidences of relapse were 15% and 26% in the standard-risk and high-risk groups, respectively. Of the 756 patients, 480 survived throughout the follow-up period of 1154 days (range: 335-3511 days) with the 3-year leukemia-free survival rates of 68% and 49% in the standard-risk and high-risk groups, respectively. Lower leukemia-free survival was associated with high-risk disease status (P = .001), chronic myelogenous leukemia disease type (P = .004), neutrophil engraftment beyond 13 days after transplant (P = .012), and the occurrence of grades 2 through 4 acute GVHD (P = .019). CONCLUSIONS: The results from the authors′ 9-year experience showed that G-BM combined with peripheral blood stem cells from haploidentical donors, without in vitro TCD, is a reliable source of stem cells for transplantation by using the protocol developed by the authors. Cancer 2013. (c) 2012 American Cancer Society.

语种英语
WOS记录号WOS:000315214000011
项目编号30971292 ; 2008zx09312-026
资助机构National Natural Science Foundation of China ; National High-tech R&amp ; D Program of China (863 Program) ; Leading Program of Clinical Faculty ; National Scientific Major Program-major new drug formulation ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation
引用统计
被引频次:114[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59206
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yu,Liu, Dai-Hong,Liu, Kai-Yan,et al. Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia Nine Years of Experience at a Single Center[J]. CANCER,2013,119(5):978-985.
APA Wang, Yu.,Liu, Dai-Hong.,Liu, Kai-Yan.,Xu, Lan-Ping.,Zhang, Xiao-Hui.,...&Huang, Xiao-Jun.(2013).Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia Nine Years of Experience at a Single Center.CANCER,119(5),978-985.
MLA Wang, Yu,et al."Long-term follow-up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia Nine Years of Experience at a Single Center".CANCER 119.5(2013):978-985.
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