IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Aristolochic acid nephropathy: variation in presentation and prognosis
Yang, Li1; Su, Tao1; Li, Xiao-Mei1; Wang, Xuan2; Cai, Shao-Qing2; Meng, Li-Qiang1; Zou, Wan-Zhong3; Wang, Hai-Yan1
关键词aristolochic acid aristolochic acid nephropathy chronic kidney disease prognosis
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2012
DOI10.1093/ndt/gfr291
27期:1页:292-298
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]CHINESE HERBS NEPHROPATHY ; INTERSTITIAL RENAL FIBROSIS ; BALKAN ENDEMIC NEPHROPATHY ; FANCONIS-SYNDROME ; IDENTIFICATION ; PATIENT ; JAPAN
英文摘要

Background. Aristolochic acid nephropathy (AAN) is a worldwide problem and one of the common causes of chronic kidney disease (CKD) in China.

Methods. Three hundred patients diagnosed as AAN from 1997 to 2006 were enrolled. Medical histories of Chinese herb ingestion, clinical-pathological features and risk factors for renal failure were recorded. Patients were followed up for 2-156 months. Factors involved in the prognosis of AAN were investigated.

Results. The 300 patients with AAN manifested three clinical subtypes, including acute kidney injury (acute AAN) in 13 patients, abrupt tubular dysfunction with normal serum creatinine (Scr) levels in seven cases and chronic tubulointerstitial nephropathy with decreased estimated glomerular filtration rate (eGFR) (chronic AAN) in 280 cases. The acute AAN cases had the highest aristolochic acid (AA)-I intake per day and developed progressive kidney failure during 1-7 years follow-up. The tubular dysfunction AAN patients had the lowest cumulative AA-I intake and were able to keep normal Scr levels during 2-8 years follow-up. The chronic AAN patients took the lowest AA-I dose per day but with the longest period and the highest cumulative dosage and exhibited a very large range of eGFR changing rate (from -21.6 to 5.2, median -3.5 mL/min/year). The cumulative AA-I intake (r = 0.330, P = 0.045) and the time course from the termination of AA medication to the start of follow-up (r = -0.430, P = 0.009) were found to be independent factors correlated with the decrease rate of eGFR in the chronic AAN patients. AA and the metabolites could be detected in a high frequency in patients who had stopped herbal medication for 1 year, which indicates a rather long washout time for these chemicals.

Conclusions. AAN has variant phenotypes with distinct prognosis, which is determined by the variable AA medications. With better understanding of toxic and environmental causes for kidney injury, there would be a better chance to uncover the causal factors of cases of ′CKD without known causes′ which is crucial for improving the disease outcomes.

语种英语
WOS记录号WOS:000299957700044
项目编号985-2001
资助机构Education Ministry of China
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59208
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
3.Peking Univ, Dept Pathol, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Li,Su, Tao,Li, Xiao-Mei,et al. Aristolochic acid nephropathy: variation in presentation and prognosis[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,27(1):292-298.
APA Yang, Li.,Su, Tao.,Li, Xiao-Mei.,Wang, Xuan.,Cai, Shao-Qing.,...&Wang, Hai-Yan.(2012).Aristolochic acid nephropathy: variation in presentation and prognosis.NEPHROLOGY DIALYSIS TRANSPLANTATION,27(1),292-298.
MLA Yang, Li,et al."Aristolochic acid nephropathy: variation in presentation and prognosis".NEPHROLOGY DIALYSIS TRANSPLANTATION 27.1(2012):292-298.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Aristolochic acid ne(280KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Li]的文章
[Su, Tao]的文章
[Li, Xiao-Mei]的文章
百度学术
百度学术中相似的文章
[Yang, Li]的文章
[Su, Tao]的文章
[Li, Xiao-Mei]的文章
必应学术
必应学术中相似的文章
[Yang, Li]的文章
[Su, Tao]的文章
[Li, Xiao-Mei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Aristolochic acid nephropathy_ variation in presentation and prognosis.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。