IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
Tang, Yong; Han, Xueyao; Sun, Xiuqin; Lv, Chao; Zhang, Xiaomei; Guo, Wulan; Ren, Qian; Luo, Yingying; Zhang, Xiuying; Zhou, Xianghai; Ji, Linong
关键词Type 2 diabetes mellitus Gene IRS1 Single nucleotide polymorphism
刊名ENDOCRINE
2013-02-01
DOI10.1007/s12020-012-9693-0
43期:1页:84-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]INSULIN-RECEPTOR SUBSTRATE-1 ; GENOME-WIDE ASSOCIATION ; BETA-CELL FUNCTION ; WAIST CIRCUMFERENCE ; GLUCOSE-TOLERANCE ; GENETIC-VARIATION ; RESISTANCE ; OBESITY ; WOMEN ; MICE
英文摘要

The insulin receptor substrate-1 (IRS1) plays an important role in insulin signaling. A recent genome-wide association study identified rs2943641C > T as a susceptibility locus for type 2 diabetes mellitus (T2DM) in Caucasian patients. Therefore, we determined whether this common variant near IRS1 is also associated with the risk of T2DM and T2DM-related phenotypes in a Chinese Han population. A total of 2,290 unrelated Chinese Han individuals residing in Beijing were recruited in this study, including 1177 T2DM patients and 1113 subjects with normal glucose tolerance (control group). The single nucleotide polymorphism (SNP) was genotyped using a MassARRAY iPLEX system. The frequency of risk allele C was 0.929 in the control group and 0.939 in patients with T2DM. We found no association between the C allele of rs2943641 and T2DM in a recessive model [OR 1.14, 95 % confidence interval (CI) 0.89-1.45, P = 0.298], or after adjusting for sex, age, and body mass index (BMI) (OR 1.10, 95 % CI 0.85-1.43, P = 0.301). Analysis of the clinical features of the control subjects with normal glucose tolerance revealed that the 30-min plasma glucose level during a 75-g oral glucose tolerance test was significantly different between the CC and CT+TT genotypes (P = 0.017). Linear regression analysis showed that the 30-min plasma glucose levels was significantly and positively associated with the CC genotype after adjusting for sex, age, and BMI (beta = 0.065, 95 % CI 0.009-0.654, P = 0.044). In addition, a potential association between this SNP and increased waist circumference (beta = 1.337, 95 % CI -0.179 to 2.853, P = 0.084) was observed with adjustment for the sex and age. Our study was not able to demonstrate the association between rs2943641 near IRS1 and T2DM in a Chinese Han population. However, this SNP may be associated with postprandial hyperglycemia.

语种英语
WOS记录号WOS:000313069600015
项目编号2006CB503900 ; 2011CB504001 ; 2006AA02A409 ; 30771031
资助机构National Basic Research Program of China (973 program) ; National High Technology Research and Development Program (863 program) ; National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59210
专题北京大学第二临床医学院
北京大学第二临床医学院_内分泌科
作者单位Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Tang, Yong,Han, Xueyao,Sun, Xiuqin,et al. Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population[J]. ENDOCRINE,2013,43(1):84-91.
APA Tang, Yong.,Han, Xueyao.,Sun, Xiuqin.,Lv, Chao.,Zhang, Xiaomei.,...&Ji, Linong.(2013).Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population.ENDOCRINE,43(1),84-91.
MLA Tang, Yong,et al."Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population".ENDOCRINE 43.1(2013):84-91.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tang, Yong]的文章
[Han, Xueyao]的文章
[Sun, Xiuqin]的文章
百度学术
百度学术中相似的文章
[Tang, Yong]的文章
[Han, Xueyao]的文章
[Sun, Xiuqin]的文章
必应学术
必应学术中相似的文章
[Tang, Yong]的文章
[Han, Xueyao]的文章
[Sun, Xiuqin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。