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学科主题: 临床医学
题名:
Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
作者: Tang, Yong; Han, Xueyao; Sun, Xiuqin; Lv, Chao; Zhang, Xiaomei; Guo, Wulan; Ren, Qian; Luo, Yingying; Zhang, Xiuying; Zhou, Xianghai; Ji, Linong
关键词: Type 2 diabetes mellitus ; Gene ; IRS1 ; Single nucleotide polymorphism
刊名: ENDOCRINE
发表日期: 2013-02-01
DOI: 10.1007/s12020-012-9693-0
卷: 43, 期:1, 页:84-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: INSULIN-RECEPTOR SUBSTRATE-1 ; GENOME-WIDE ASSOCIATION ; BETA-CELL FUNCTION ; WAIST CIRCUMFERENCE ; GLUCOSE-TOLERANCE ; GENETIC-VARIATION ; RESISTANCE ; OBESITY ; WOMEN ; MICE
英文摘要:

The insulin receptor substrate-1 (IRS1) plays an important role in insulin signaling. A recent genome-wide association study identified rs2943641C > T as a susceptibility locus for type 2 diabetes mellitus (T2DM) in Caucasian patients. Therefore, we determined whether this common variant near IRS1 is also associated with the risk of T2DM and T2DM-related phenotypes in a Chinese Han population. A total of 2,290 unrelated Chinese Han individuals residing in Beijing were recruited in this study, including 1177 T2DM patients and 1113 subjects with normal glucose tolerance (control group). The single nucleotide polymorphism (SNP) was genotyped using a MassARRAY iPLEX system. The frequency of risk allele C was 0.929 in the control group and 0.939 in patients with T2DM. We found no association between the C allele of rs2943641 and T2DM in a recessive model [OR 1.14, 95 % confidence interval (CI) 0.89-1.45, P = 0.298], or after adjusting for sex, age, and body mass index (BMI) (OR 1.10, 95 % CI 0.85-1.43, P = 0.301). Analysis of the clinical features of the control subjects with normal glucose tolerance revealed that the 30-min plasma glucose level during a 75-g oral glucose tolerance test was significantly different between the CC and CT+TT genotypes (P = 0.017). Linear regression analysis showed that the 30-min plasma glucose levels was significantly and positively associated with the CC genotype after adjusting for sex, age, and BMI (beta = 0.065, 95 % CI 0.009-0.654, P = 0.044). In addition, a potential association between this SNP and increased waist circumference (beta = 1.337, 95 % CI -0.179 to 2.853, P = 0.084) was observed with adjustment for the sex and age. Our study was not able to demonstrate the association between rs2943641 near IRS1 and T2DM in a Chinese Han population. However, this SNP may be associated with postprandial hyperglycemia.

语种: 英语
所属项目编号: 2006CB503900 ; 2011CB504001 ; 2006AA02A409 ; 30771031
项目资助者: National Basic Research Program of China (973 program) ; National High Technology Research and Development Program (863 program) ; National Natural Science Foundation of China
WOS记录号: WOS:000313069600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59210
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China

Recommended Citation:
Tang, Yong,Han, Xueyao,Sun, Xiuqin,et al. Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population[J]. ENDOCRINE,2013,43(1):84-91.
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