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学科主题: 临床医学
题名:
A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles
作者: Jia, Zhaojun1; Li, Ming1; Xiu, Peng2; Xu, Xuchen1; Cheng, Yan1; Zheng, Yufeng1,3; Xi, Tingfei1; Wei, Shicheng1,4; Liu, Zhongjun2
关键词: Electron beam melting (EBM) ; Micro-arc oxidization (MAO) ; Poly(dopamine) (PD) ; Silver nanoparticles (AgNPs)
刊名: MATERIALS LETTERS
发表日期: 2015-10-15
DOI: 10.1016/j.matlet.2015.05.084
卷: 157, 页:143-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Materials Science ; Physics
关键词[WOS]: MICRO-ARC OXIDATION ; IMPLANTS ; STRESS
英文摘要:

Owing to their mechanical properties and bioinertness titanium alloys remain the preferred load-bearing implant material in orthopedics. However, unsatisfactory osteointegration and risks of infection are the two major problems. Herein, Ti6Al4V prostheses with 3D hierarchical (macro/micro-nano) porosity were constructed by combining the state-of-art electron beam melting (EBM) additive manufacturing (AM) process with a traditional micro-arc oxidization (MAO) technique for enhanced integration with bone tissues, and as a measure to improve their antimicrobial properties, releasable silver nanoparticles (AgNPs) were homogeneously immobilized on the multi-scaled porous surfaces via a mussel-inspired strategy. The cytocompatibility of the engineered scaffolds (EBM-MAO/Ag) outperformed the untreated, due to synergistic benefits from micro/nano-porous topography and adhesive chemical composition. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: Z141100002814008 ; 31370954 ; 2012CB619102
项目资助者: Grants of the Project of Scientific and Technical Plan of Beijing ; National Natural Science Foundation of China ; State Key Laboratory of Bioelectronics Open Research Fund of China (Chien-Shiung Wu Laboratory) ; National Basic Research Program (973) of China
WOS记录号: WOS:000358973500037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59216
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
2.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Adv Mat & Nanotechnol, Coll Engn, Beijing 100871, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China

Recommended Citation:
Jia, Zhaojun,Li, Ming,Xiu, Peng,et al. A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles[J]. MATERIALS LETTERS,2015,157:143-146.
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