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学科主题: 公共卫生
题名:
Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice
作者: Yang, Ruiyue; Zhang, Zhaofeng; Pei, Xinrong; Han, Xiaolong; Wang, Junbo; Wang, Linlin; Long, Zhu; Shen, Xiaoyi; Li, Yong
关键词: Immunomodulatory peptide ; T cell subpopulation ; Cytokine ; Bead-based multiplex assay
刊名: FOOD CHEMISTRY
发表日期: 2009-03-15
DOI: 10.1016/j.foodchem.2008.07.086
卷: 113, 期:2, 页:464-470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: ENZYME INHIBITORY PEPTIDE ; PROTEIN HYDROLYSATE ; GELATIN HYDROLYSATE ; BIOACTIVE PEPTIDES ; SOYBEAN PROTEIN ; CYTOKINES ; RESPONSES ; ASSAY ; RATS ; SKIN
英文摘要:

To observe the immunomodulatory effects of marine oligopeptide preparation (MOP) from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, female ICR mice (6-8 weeks old) were administered the MOP for four weeks with the dose of 0, 0.22, 0.45 and 1.35 g/kg/body weight. In comparison with the control group, the MOP could significantly enhance the capacity of lymphocyte proliferation induced by the mitogen concanavalin A, the number of plaque-forming cells, natural killer cell activity, the percentage of CD4(+) T helper (Th) cells in spleen and the secretion of Th1 (IL-2, IFN-gamma) and Th2 (IL-5, IL-6) type cell cytokines. Nevertheless, no significant differences in weight gain, lymphoid organ indices and phagocytosis capacity were observed in our study. These results suggest that MOP is a possible immune stimulant and may strengthen the immune response of its host. (c) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006BAD271308
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000261084600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59224
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Ruiyue,Zhang, Zhaofeng,Pei, Xinrong,et al. Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice[J]. FOOD CHEMISTRY,2009,113(2):464-470.
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