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Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice
Yang, Ruiyue; Zhang, Zhaofeng; Pei, Xinrong; Han, Xiaolong; Wang, Junbo; Wang, Linlin; Long, Zhu; Shen, Xiaoyi; Li, Yong
关键词Immunomodulatory peptide T cell subpopulation Cytokine Bead-based multiplex assay
刊名FOOD CHEMISTRY
2009-03-15
DOI10.1016/j.foodchem.2008.07.086
113期:2页:464-470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]ENZYME INHIBITORY PEPTIDE ; PROTEIN HYDROLYSATE ; GELATIN HYDROLYSATE ; BIOACTIVE PEPTIDES ; SOYBEAN PROTEIN ; CYTOKINES ; RESPONSES ; ASSAY ; RATS ; SKIN
英文摘要

To observe the immunomodulatory effects of marine oligopeptide preparation (MOP) from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, female ICR mice (6-8 weeks old) were administered the MOP for four weeks with the dose of 0, 0.22, 0.45 and 1.35 g/kg/body weight. In comparison with the control group, the MOP could significantly enhance the capacity of lymphocyte proliferation induced by the mitogen concanavalin A, the number of plaque-forming cells, natural killer cell activity, the percentage of CD4(+) T helper (Th) cells in spleen and the secretion of Th1 (IL-2, IFN-gamma) and Th2 (IL-5, IL-6) type cell cytokines. Nevertheless, no significant differences in weight gain, lymphoid organ indices and phagocytosis capacity were observed in our study. These results suggest that MOP is a possible immune stimulant and may strengthen the immune response of its host. (c) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000261084600014
项目编号2006BAD271308
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:64[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59224
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Ruiyue,Zhang, Zhaofeng,Pei, Xinrong,et al. Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice[J]. FOOD CHEMISTRY,2009,113(2):464-470.
APA Yang, Ruiyue.,Zhang, Zhaofeng.,Pei, Xinrong.,Han, Xiaolong.,Wang, Junbo.,...&Li, Yong.(2009).Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice.FOOD CHEMISTRY,113(2),464-470.
MLA Yang, Ruiyue,et al."Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice".FOOD CHEMISTRY 113.2(2009):464-470.
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