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HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress
Ji, Yajuan1,2; Yang, Fang1,2; Ma, Dongmei1,2; Zhang, Jinqing1,2; Wan, Zhe1,2; Liu, Wei1,2; Li, Ruoyu1,2
关键词Aspergillus fumigatus HOG-MAPK tcsB Thermal stress SakA
刊名MYCOPATHOLOGIA
2012-10-01
DOI10.1007/s11046-012-9557-4
174期:4页:273-282
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]ACTIVATED PROTEIN-KINASE ; CELL-WALL INTEGRITY ; INVASIVE ASPERGILLOSIS ; MEMBRANE-FLUIDITY ; SACCHAROMYCES-CEREVISIAE ; HEAT-STRESS ; PSEUDOMONAS-AERUGINOSA ; 2-COMPONENT SYSTEM ; OXIDANT ADAPTATION ; YEAST
英文摘要

Aspergillus fumigatus is naturally exposed to a highly variable environment and subjected to various kinds of stresses. High-osmolarity glycerol mitogen-activated protein kinase (HOG-MAPK) pathway plays a crucial role in regulating cellular homeostasis in response to environmental changes. Here, we explored the contribution of HOG-MAPK pathway to the adaptive responses to thermal stress and other related stresses in A. fumigatus. We observed the phenotype features of wild-type strains and their derived mutants at 37 and 48 A degrees C, and the results suggested that tcsB participates in response to high temperature. Furthermore, susceptibility test for antifungal drugs showed that SHO1 branch is probably involved in the susceptibility of A. fumigatus to itraconazole at high temperature. Although sakA expression at mRNA level appeared unchanged in wild-type AF293 subjected to thermal stress, phosphorylated SakAp level increased significantly in the strains exposed to cold stress, 250 mmol/L nystatin or 10 % dimethyl sulfoxide in a manner dependent on the SLN1 branch and independent on the SHO1 branch. Taken together, these results indicate that HOG-MAPK pathway, especially the SLN1 branch, plays an important role in the adaptations of A. fumigatus to thermal stress and other related stresses.

语种英语
WOS记录号WOS:000308645900002
项目编号30930006
资助机构National Fund of Natural Sciences in China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59225
专题北京大学第一临床医学院
北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100034, Peoples R China
2.Peking Univ, Res Ctr Med Mycol, Beijing 100034, Peoples R China
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GB/T 7714
Ji, Yajuan,Yang, Fang,Ma, Dongmei,et al. HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress[J]. MYCOPATHOLOGIA,2012,174(4):273-282.
APA Ji, Yajuan.,Yang, Fang.,Ma, Dongmei.,Zhang, Jinqing.,Wan, Zhe.,...&Li, Ruoyu.(2012).HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress.MYCOPATHOLOGIA,174(4),273-282.
MLA Ji, Yajuan,et al."HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress".MYCOPATHOLOGIA 174.4(2012):273-282.
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