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学科主题: 临床医学
题名:
HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress
作者: Ji, Yajuan1,2; Yang, Fang1,2; Ma, Dongmei1,2; Zhang, Jinqing1,2; Wan, Zhe1,2; Liu, Wei1,2; Li, Ruoyu1,2
关键词: Aspergillus fumigatus ; HOG-MAPK ; tcsB ; Thermal stress ; SakA
刊名: MYCOPATHOLOGIA
发表日期: 2012-10-01
DOI: 10.1007/s11046-012-9557-4
卷: 174, 期:4, 页:273-282
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; CELL-WALL INTEGRITY ; INVASIVE ASPERGILLOSIS ; MEMBRANE-FLUIDITY ; SACCHAROMYCES-CEREVISIAE ; HEAT-STRESS ; PSEUDOMONAS-AERUGINOSA ; 2-COMPONENT SYSTEM ; OXIDANT ADAPTATION ; YEAST
英文摘要:

Aspergillus fumigatus is naturally exposed to a highly variable environment and subjected to various kinds of stresses. High-osmolarity glycerol mitogen-activated protein kinase (HOG-MAPK) pathway plays a crucial role in regulating cellular homeostasis in response to environmental changes. Here, we explored the contribution of HOG-MAPK pathway to the adaptive responses to thermal stress and other related stresses in A. fumigatus. We observed the phenotype features of wild-type strains and their derived mutants at 37 and 48 A degrees C, and the results suggested that tcsB participates in response to high temperature. Furthermore, susceptibility test for antifungal drugs showed that SHO1 branch is probably involved in the susceptibility of A. fumigatus to itraconazole at high temperature. Although sakA expression at mRNA level appeared unchanged in wild-type AF293 subjected to thermal stress, phosphorylated SakAp level increased significantly in the strains exposed to cold stress, 250 mmol/L nystatin or 10 % dimethyl sulfoxide in a manner dependent on the SLN1 branch and independent on the SHO1 branch. Taken together, these results indicate that HOG-MAPK pathway, especially the SLN1 branch, plays an important role in the adaptations of A. fumigatus to thermal stress and other related stresses.

语种: 英语
所属项目编号: 30930006
项目资助者: National Fund of Natural Sciences in China
WOS记录号: WOS:000308645900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59225
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100034, Peoples R China
2.Peking Univ, Res Ctr Med Mycol, Beijing 100034, Peoples R China

Recommended Citation:
Ji, Yajuan,Yang, Fang,Ma, Dongmei,et al. HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress[J]. MYCOPATHOLOGIA,2012,174(4):273-282.
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