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学科主题: 基础医学
题名:
Change of vanilloid receptor I expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund′s adjuvant in rats
作者: Luo, H; Cheng, J; Han, JS; Wan, Y
关键词: complete Freund&prime ; s adjuvant ; dorsal root ganglion ; inflammatory pain ; spinal cord ; VRI
刊名: NEUROREPORT
发表日期: 2004-03-22
DOI: 10.1097/01.wnr.0000118721.38067.44
卷: 15, 期:4, 页:655-658
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CAPSAICIN-RECEPTOR ; PAIN ; HYPERALGESIA ; NEURONS ; CAPSAZEPINE ; ACTIVATION ; MICE
英文摘要:

The present study aimed to systematically observe the change of vanilloid receptor I (VRI) during inflammatory nociception induced by intraplantar injection of complete Freund′s adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistochemistry to observe VRI expression in dorsal root ganglion and spinal cord dorsal horn. Results showed that HPL decreased from day 1 to day 28 after CFA injection, with shortest at day 14. VRI expression correspondingly increased from day 1 to day 21 with peak at day 14, and returning to the control level at day 28. A shift of VRI expression from small to medium DRG neurons over the observation period was seen. These results suggest that VRI could play an important role in the early stage, but not the late stage, of CFA inflammatory nociception.

语种: 英语
WOS记录号: WOS:000225140100016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59227
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Key Lab Neurosci, Minist Educ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Luo, H,Cheng, J,Han, JS,et al. Change of vanilloid receptor I expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund′s adjuvant in rats[J]. NEUROREPORT,2004,15(4):655-658.
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