学科主题临床医学
Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer
Li, Jing Nan1; Zhao, Li1; Wu, Jun1; Wu, Bin2; Yang, Hong1; Zhang, Heng Hui3; Qian, Jia Ming
关键词colon cancer gene profile rectal cancer signal pathway
刊名JOURNAL OF DIGESTIVE DISEASES
2012
DOI10.1111/j.1751-2980.2011.00551.x
13期:1页:24-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]COLORECTAL-CANCER ; PROTEOMIC ANALYSIS ; PROTEIN ; S100P ; TUMORIGENESIS ; REGULATOR ; MIGRATION ; GROWTH ; STAGE
英文摘要

OBJECTIVE: Colon cancer is more common in the USA and Europe than that in China, for reasons that are unclear. The aim of this study was to investigate the differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.

METHODS: Expression profiling of primary tumor tissues from 12 colon and 12 rectal cancers was performed using oligonucleotide microarray analysis. All samples were strictly matched by clinical features. Bioinformatic analyses such as the Kyoto Encyclopedia of Genes and Genomes were used to identify genes and pathways specifically associated with colon or rectal cancers.

RESULTS: A total of 824 genes were differentially expressed in colon and rectal cancers. All differential gene interactions in the Signal-Net were analyzed. More genes were differentially expressed and included in the Signal- Net for rectal than colon cancer. Of the genes differentially expressed between colon and rectal cancer, S100P, the Reg family, ACTN1, CAMK2G and ACAT1 were the most significantly altered. Genes involved in the cell cycle pathway were present in rectal and colon cancers, but were more important in rectal cancer. The p53 and metabolic signaling pathways were significantly different in colon and rectal cancers. Gene expression profiles differed between colon and rectal cancer, with metabolic pathways being more important in rectal cancer.

CONCLUSION: The oncogenesis of rectal cancer may be more complex than that of colon cancer. Some genes could be new biomarkers for distinguishing between these two cancers.

语种英语
WOS记录号WOS:000298480100005
项目编号Z080507030808012
资助机构Beijing Municipal Science and Technology Commission
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59235
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100730, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Jing Nan,Zhao, Li,Wu, Jun,et al. Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer[J]. JOURNAL OF DIGESTIVE DISEASES,2012,13(1):24-32.
APA Li, Jing Nan.,Zhao, Li.,Wu, Jun.,Wu, Bin.,Yang, Hong.,...&Qian, Jia Ming.(2012).Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.JOURNAL OF DIGESTIVE DISEASES,13(1),24-32.
MLA Li, Jing Nan,et al."Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer".JOURNAL OF DIGESTIVE DISEASES 13.1(2012):24-32.
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