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学科主题: 临床医学
题名:
Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer
作者: Li, Jing Nan1; Zhao, Li1; Wu, Jun1; Wu, Bin2; Yang, Hong1; Zhang, Heng Hui3; Qian, Jia Ming
关键词: colon cancer ; gene profile ; rectal cancer ; signal pathway
刊名: JOURNAL OF DIGESTIVE DISEASES
发表日期: 2012
DOI: 10.1111/j.1751-2980.2011.00551.x
卷: 13, 期:1, 页:24-32
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: COLORECTAL-CANCER ; PROTEOMIC ANALYSIS ; PROTEIN ; S100P ; TUMORIGENESIS ; REGULATOR ; MIGRATION ; GROWTH ; STAGE
英文摘要:

OBJECTIVE: Colon cancer is more common in the USA and Europe than that in China, for reasons that are unclear. The aim of this study was to investigate the differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer.

METHODS: Expression profiling of primary tumor tissues from 12 colon and 12 rectal cancers was performed using oligonucleotide microarray analysis. All samples were strictly matched by clinical features. Bioinformatic analyses such as the Kyoto Encyclopedia of Genes and Genomes were used to identify genes and pathways specifically associated with colon or rectal cancers.

RESULTS: A total of 824 genes were differentially expressed in colon and rectal cancers. All differential gene interactions in the Signal-Net were analyzed. More genes were differentially expressed and included in the Signal- Net for rectal than colon cancer. Of the genes differentially expressed between colon and rectal cancer, S100P, the Reg family, ACTN1, CAMK2G and ACAT1 were the most significantly altered. Genes involved in the cell cycle pathway were present in rectal and colon cancers, but were more important in rectal cancer. The p53 and metabolic signaling pathways were significantly different in colon and rectal cancers. Gene expression profiles differed between colon and rectal cancer, with metabolic pathways being more important in rectal cancer.

CONCLUSION: The oncogenesis of rectal cancer may be more complex than that of colon cancer. Some genes could be new biomarkers for distinguishing between these two cancers.

语种: 英语
所属项目编号: Z080507030808012
项目资助者: Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000298480100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59235
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100730, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China

Recommended Citation:
Li, Jing Nan,Zhao, Li,Wu, Jun,et al. Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer[J]. JOURNAL OF DIGESTIVE DISEASES,2012,13(1):24-32.
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