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Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice
Feng, Juan1,2; Zhang, Zhenmin1,2; Kong, Wei1,2; Liu, Bo1,2; Xu, Qingbo3; Wang, Xian1,2
关键词Regulatory T cells Atherosclerosis Hyperhomocysteinaemia Immunoinflammatory diseases T lymphocytes
刊名CARDIOVASCULAR RESEARCH
2009-10-01
DOI10.1093/cvr/cvp182
84期:1页:155-163
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]POTENTIAL ROLE ; HOMOCYSTEINE ; FOXP3 ; INFLAMMATION ; MECHANISMS ; INDUCTION ; IMMUNITY ; PROLIFERATION ; EXPRESSION ; TOLERANCE
英文摘要

Atherosclerosis is an inflammatory disease with T cell-driven immunoinflammatory responses contributing to disease initiation and progression. We investigated the potential role of regulatory T cells (Tregs) in hyperhomocysteinaemia (HHcy)-accelerated atherosclerosis in apoE-/- mice.

apoE-/- mice were fed normal mouse chow supplemented with or without a high level of homocysteine (Hcy) (1.8 g/L) in drinking water for 2, 4, and 6 weeks. Atherosclerotic lesion area was slightly increased at 2 weeks and substantially elevated at 4 and 6 weeks in HHcy apoE-/- mice. Cotransfer of normal Tregs significantly attenuated atherosclerotic lesion size and infiltration of T cells and macrophages into plaque. Furthermore, Treg cotransfer reversed HHcy-accelerated proliferation of T cells, -increased pro-inflammatory, and -decreased anti-inflammatory cytokine secretion from activated splenic T cells. With a clinically relevant level of plasma Hcy, the proportion of Tregs and suppressive activity in splenic T cells were reduced in HHcy apoE-/- mice, which was associated with reduced mRNA and protein expression of Foxp3, a factor governing mouse Treg development and function. In addition, Hcy significantly attenuated the proportion and suppressive effects of Tregs in vitro.

HHcy suppresses the function of Tregs, which may be responsible for HHcy-accelerated atherosclerosis in apoE-/- mice.

语种英语
WOS记录号WOS:000269735600021
项目编号30730042 ; 30570714 ; 30821001 ; 2006CB503802
资助机构National Natural Science Foundation of the PR China ; National Basic Research Program of the PR China ; Chang Jiang Scholars Program
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59236
专题北京大学基础医学院
北京大学医学部管理机构_人事处
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Kings Coll London, BHF Ctr, Div Cardiovasc, London SE5 9NU, England
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GB/T 7714
Feng, Juan,Zhang, Zhenmin,Kong, Wei,et al. Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice[J]. CARDIOVASCULAR RESEARCH,2009,84(1):155-163.
APA Feng, Juan,Zhang, Zhenmin,Kong, Wei,Liu, Bo,Xu, Qingbo,&Wang, Xian.(2009).Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice.CARDIOVASCULAR RESEARCH,84(1),155-163.
MLA Feng, Juan,et al."Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice".CARDIOVASCULAR RESEARCH 84.1(2009):155-163.
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