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学科主题: 基础医学
题名:
Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice
作者: Feng, Juan1,2; Zhang, Zhenmin1,2; Kong, Wei1,2; Liu, Bo1,2; Xu, Qingbo3; Wang, Xian1,2
关键词: Regulatory T cells ; Atherosclerosis ; Hyperhomocysteinaemia ; Immunoinflammatory diseases ; T lymphocytes
刊名: CARDIOVASCULAR RESEARCH
发表日期: 2009-10-01
DOI: 10.1093/cvr/cvp182
卷: 84, 期:1, 页:155-163
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: POTENTIAL ROLE ; HOMOCYSTEINE ; FOXP3 ; INFLAMMATION ; MECHANISMS ; INDUCTION ; IMMUNITY ; PROLIFERATION ; EXPRESSION ; TOLERANCE
英文摘要:

Atherosclerosis is an inflammatory disease with T cell-driven immunoinflammatory responses contributing to disease initiation and progression. We investigated the potential role of regulatory T cells (Tregs) in hyperhomocysteinaemia (HHcy)-accelerated atherosclerosis in apoE-/- mice.

apoE-/- mice were fed normal mouse chow supplemented with or without a high level of homocysteine (Hcy) (1.8 g/L) in drinking water for 2, 4, and 6 weeks. Atherosclerotic lesion area was slightly increased at 2 weeks and substantially elevated at 4 and 6 weeks in HHcy apoE-/- mice. Cotransfer of normal Tregs significantly attenuated atherosclerotic lesion size and infiltration of T cells and macrophages into plaque. Furthermore, Treg cotransfer reversed HHcy-accelerated proliferation of T cells, -increased pro-inflammatory, and -decreased anti-inflammatory cytokine secretion from activated splenic T cells. With a clinically relevant level of plasma Hcy, the proportion of Tregs and suppressive activity in splenic T cells were reduced in HHcy apoE-/- mice, which was associated with reduced mRNA and protein expression of Foxp3, a factor governing mouse Treg development and function. In addition, Hcy significantly attenuated the proportion and suppressive effects of Tregs in vitro.

HHcy suppresses the function of Tregs, which may be responsible for HHcy-accelerated atherosclerosis in apoE-/- mice.

语种: 英语
所属项目编号: 30730042 ; 30570714 ; 30821001 ; 2006CB503802
项目资助者: National Natural Science Foundation of the PR China ; National Basic Research Program of the PR China ; Chang Jiang Scholars Program
WOS记录号: WOS:000269735600021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59236
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Kings Coll London, BHF Ctr, Div Cardiovasc, London SE5 9NU, England

Recommended Citation:
Feng, Juan,Zhang, Zhenmin,Kong, Wei,et al. Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice[J]. CARDIOVASCULAR RESEARCH,2009,84(1):155-163.
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