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Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities
Stevens, Lesley A.1; Claybon, Marcie A.; Schmid, Christopher H.; Chen, Jing2; Horio, Masaru3; Imai, Enyu3; Nelson, Robert G.4; Van Deventer, Manuel5,6; Wang, Hai-Yan7; Zuo, Li7; Zhang, Yaping; Levey, Andrew S.
关键词creatinine ethnicity glomerular filtration rate
刊名KIDNEY INTERNATIONAL
2011-03-01
DOI10.1038/ki.2010.462
79期:5页:555-562
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GFR-ESTIMATING EQUATIONS ; SERUM CREATININE ; MUSCLE MASS ; CYSTATIN-C ; ADULTS ; AGE
英文摘要

An equation from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) provides more accurate estimates of the glomerular filtration rate (eGFR) than that from the modification of diet in renal disease (MDRD) Study, although both include a two-level variable for race (Black and White and other). Since creatinine generation differs among ethnic groups, it is possible that a multilevel ethnic variable would allow more accurate estimates across all groups. To evaluate this, we developed an equation to calculate eGFR that includes a four-level race variable (Black, Asian, Native American and Hispanic, and White and other) using a database of 8254 patients pooled from 10 studies. This equation was then validated in 4014 patients using 17 additional studies from the United States and Europe (validation database), and in 1022 patients from China (675), Japan (248), and South Africa (99). Coefficients for the Black, Asian, and Native American and Hispanic groups resulted in 15, 5, and 1% higher levels of eGFR, respectively, compared with the White and other group. In the validation database, the two-level race equation had minimal bias in Black, Native American and Hispanic, and White and other cohorts. The four-level ethnicity equation significantly improved bias in Asians of the validation data set and in Chinese. Both equations had a large bias in Japanese and South African patients. Thus, heterogeneity in performance among the ethnic and geographic groups precludes use of the four-level race equation. The CKD-EPI two-level race equation can be used in the United States and Europe across a wide range of ethnicity. Kidney International (2011) 79, 555-562; doi: 10.1038/ki.2010.462; published online 24 November 2010

语种英语
所属项目编号UO1 DK 053869 ; UO1 DK 067651 ; UO1 DK 35073
WOS记录号WOS:000287353000011
引用统计
被引频次:121[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59238
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.Tufts Med Ctr, Div Nephrol, Boston, MA 02111 USA
3.Tulane Univ, Sch Med, New Orleans, LA 70112 USA
4.Osaka Univ, Grad Sch Med, Osaka, Japan
5.Univ Witwatersrand, NHLS, Johannesburg, South Africa
6.NIDDK, Phoenix, AZ USA
7.Univ Witwatersrand, Dept Chem Pathol, Johannesburg, South Africa
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GB/T 7714
Stevens, Lesley A.,Claybon, Marcie A.,Schmid, Christopher H.,et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities[J]. KIDNEY INTERNATIONAL,2011,79(5):555-562.
APA Stevens, Lesley A..,Claybon, Marcie A..,Schmid, Christopher H..,Chen, Jing.,Horio, Masaru.,...&Levey, Andrew S..(2011).Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities.KIDNEY INTERNATIONAL,79(5),555-562.
MLA Stevens, Lesley A.,et al."Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities".KIDNEY INTERNATIONAL 79.5(2011):555-562.
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