北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities
作者: Stevens, Lesley A.1; Claybon, Marcie A.; Schmid, Christopher H.; Chen, Jing2; Horio, Masaru3; Imai, Enyu3; Nelson, Robert G.4; Van Deventer, Manuel5,6; Wang, Hai-Yan7; Zuo, Li7; Zhang, Yaping; Levey, Andrew S.
关键词: creatinine ; ethnicity ; glomerular filtration rate
刊名: KIDNEY INTERNATIONAL
发表日期: 2011-03-01
DOI: 10.1038/ki.2010.462
卷: 79, 期:5, 页:555-562
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GFR-ESTIMATING EQUATIONS ; SERUM CREATININE ; MUSCLE MASS ; CYSTATIN-C ; ADULTS ; AGE
英文摘要:

An equation from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) provides more accurate estimates of the glomerular filtration rate (eGFR) than that from the modification of diet in renal disease (MDRD) Study, although both include a two-level variable for race (Black and White and other). Since creatinine generation differs among ethnic groups, it is possible that a multilevel ethnic variable would allow more accurate estimates across all groups. To evaluate this, we developed an equation to calculate eGFR that includes a four-level race variable (Black, Asian, Native American and Hispanic, and White and other) using a database of 8254 patients pooled from 10 studies. This equation was then validated in 4014 patients using 17 additional studies from the United States and Europe (validation database), and in 1022 patients from China (675), Japan (248), and South Africa (99). Coefficients for the Black, Asian, and Native American and Hispanic groups resulted in 15, 5, and 1% higher levels of eGFR, respectively, compared with the White and other group. In the validation database, the two-level race equation had minimal bias in Black, Native American and Hispanic, and White and other cohorts. The four-level ethnicity equation significantly improved bias in Asians of the validation data set and in Chinese. Both equations had a large bias in Japanese and South African patients. Thus, heterogeneity in performance among the ethnic and geographic groups precludes use of the four-level race equation. The CKD-EPI two-level race equation can be used in the United States and Europe across a wide range of ethnicity. Kidney International (2011) 79, 555-562; doi: 10.1038/ki.2010.462; published online 24 November 2010

语种: 英语
所属项目编号: UO1 DK 053869 ; UO1 DK 067651 ; UO1 DK 35073
WOS记录号: WOS:000287353000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59238
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.Tufts Med Ctr, Div Nephrol, Boston, MA 02111 USA
3.Tulane Univ, Sch Med, New Orleans, LA 70112 USA
4.Osaka Univ, Grad Sch Med, Osaka, Japan
5.Univ Witwatersrand, NHLS, Johannesburg, South Africa
6.NIDDK, Phoenix, AZ USA
7.Univ Witwatersrand, Dept Chem Pathol, Johannesburg, South Africa

Recommended Citation:
Stevens, Lesley A.,Claybon, Marcie A.,Schmid, Christopher H.,et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities[J]. KIDNEY INTERNATIONAL,2011,79(5):555-562.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Stevens, Lesley A.]'s Articles
[Claybon, Marcie A.]'s Articles
[Schmid, Christopher H.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Stevens, Lesley A.]‘s Articles
[Claybon, Marcie A.]‘s Articles
[Schmid, Christopher H.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace