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学科主题: 临床医学
题名:
Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPAR gamma-Dependent Nongenomic Signaling
作者: Endo, Yoko1; Suzuki, Masashi1; Yamada, Hideomi1; Horita, Shoko1; Kunimi, Motoei1; Yamazaki, Osamu1; Shirai, Ayumi1; Nakamura, Motonobu1; Iso-O, Naoyuki1; Li, Yuehong1,3; Hara, Masumi1; Tsukamoto, Kazuhisa1; Moriyama, Nobuo4; Kudo, Akihiko5; Kawakami, Hayato5; Yamauchi, Toshimasa1; Kubota, Naoto1; Kadowaki, Takashi1; Kume, Haruki2; Enomoto, Yutaka2; Homma, Yukio2; Seki, George1; Fujita, Toshiro1
刊名: CELL METABOLISM
发表日期: 2011-05-04
DOI: 10.1016/j.cmet.2011.02.015
卷: 13, 期:5, 页:550-561
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Endocrinology & Metabolism
研究领域[WOS]: Cell Biology ; Endocrinology & Metabolism
关键词[WOS]: INDUCED FLUID RETENTION ; GROWTH-FACTOR-RECEPTOR ; BIPHASIC REGULATION ; CELLULAR ACIDOSIS ; UP-REGULATION ; CELLS ; TRANSPORT ; STIMULATION ; ACTIVATION ; ESTROGEN
英文摘要:

Thiazolidinediones (TZDs) improve insulin resistance by activating a nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma). However, the use of TZDs is associated with plasma volume expansion through a mechanism that remains to be clarified. Here we showed that TZDs rapidly stimulate sodium-coupled bicarbonate absorption from the renal proximal tubule in vitro and in vivo. TZD-induced transport stimulation is dependent on PPAR gamma-Src-EGFR-ERK and observed in rat, rabbit and human, but not in mouse proximal tubules where Src-EGFR is constitutively activated. The existence of PPAR gamma-Src-dependent nongenomic signaling, which requires the ligand-binding ability, but not the transcriptional activity of PPAR gamma, is confirmed in mouse embryonic fibroblast cells. The enhancement of the association between PPAR gamma and Src by TZDs supports an indispensable role of Src in this signaling. These results suggest that the PPAR gamma-dependent nongenomic stimulation of renal proximal transport is also involved in TZD-induced volume expansion.

语种: 英语
项目资助者: Ministry of Education, Culture, Sports, Science and Technology of Japan ; Takeda Pharmaceutical Co., Ltd.
WOS记录号: WOS:000290291300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59242
Appears in Collections:北京大学第二临床医学院_肾内科_期刊论文

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作者单位: 1.Univ Tokyo, Dept Internal Med, Tokyo 1130033, Japan
2.Univ Tokyo, Dept Urol, Fac Med, Tokyo 1130033, Japan
3.Peking Univ, Dept Nephrol, Peoples Hosp, Beijing 100044, Peoples R China
4.Fukuoka Prefectural Univ, Dept Expt Nursing, Fac Nursing, Fukuoka 8258585, Japan
5.Kyorin Univ, Dept Anat, Sch Med, Tokyo 1818611, Japan

Recommended Citation:
Endo, Yoko,Suzuki, Masashi,Yamada, Hideomi,et al. Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPAR gamma-Dependent Nongenomic Signaling[J]. CELL METABOLISM,2011,13(5):550-561.
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