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学科主题: 临床医学
题名:
The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients
作者: Luo, Huan; Chen, Min1; Cui, Zhao; Yang, Rui; Xu, Peng-Cheng; Zhou, Xu-Jie; Zhao, Ming-Hui
关键词: Anti-GBM disease HLA-DPB1*0401 ; Chinese
刊名: BMC NEPHROLOGY
发表日期: 2011-05-13
DOI: 10.1186/1471-2369-12-21
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GOODPASTURES-DISEASE ; HLA ; SUSCEPTIBILITY ; AUTOANTIBODIES ; SEVERITY ; OUTCOMES ; LOCUS ; CELLS
英文摘要:

Background: Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was strongly associated with anti-GBM disease in Chinese. However, the association of anti-GBM disease and other HLA class II genes, including HLA-DQB1, -DQA1, -DPB1 alleles, has rarely been investigated in Asian, especially Chinese patients. The present study further analyzed the association between anti-GBM disease and HLA-DQB1, -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk amino acid residues of anti-GBM disease.

Methods: This study included 44 Chinese patients with anti-GBM disease and 200 healthy controls. The clinical and pathological data of the patients were collected and analyzed. Typing of HLA-DQB1, -DQA1 and -DPB1 alleles were performed by bi-directional sequencing of exon 2 using the SeCoreTM Sequencing Kits.

Results: Compared with normal controls, the prevalence of HLA-DPB1*0401 was significantly lower in patients with anti-GBM disease (3/88 vs. 74/400, p = 4.4 x 10(-4), pc = 0.039). Comparing with normal controls, the combination of presence of DRB1*1501 and absence of DPB1*0401 was significantly prominent among anti-GBM patients (p = 2.0 x 10(-12), pc = 1.7 x 10(-10)).

Conclusions: HLA-DPB1*0401 might be a protective allele to anti-GBM disease in Chinese patients. The combined presence of DRB1*1501 and absence of DPB1*0401 might have an even higher risk to anti-GBM disease than HLA-DRB1*1501 alone.

语种: 英语
所属项目编号: 30725034 ; 30972733
项目资助者: National Science Foundation for Distinguished Young Scholars ; National Natural Science Fund
WOS记录号: WOS:000304358600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59248
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China

Recommended Citation:
Luo, Huan,Chen, Min,Cui, Zhao,et al. The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients[J]. BMC NEPHROLOGY,2011,12.
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