|The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients|
|Luo, Huan; Chen, Min1; Cui, Zhao; Yang, Rui; Xu, Peng-Cheng; Zhou, Xu-Jie; Zhao, Ming-Hui|
|关键词||Anti-GBM disease HLA-DPB1*0401 Chinese|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||GOODPASTURES-DISEASE ; HLA ; SUSCEPTIBILITY ; AUTOANTIBODIES ; SEVERITY ; OUTCOMES ; LOCUS ; CELLS|
Background: Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was strongly associated with anti-GBM disease in Chinese. However, the association of anti-GBM disease and other HLA class II genes, including HLA-DQB1, -DQA1, -DPB1 alleles, has rarely been investigated in Asian, especially Chinese patients. The present study further analyzed the association between anti-GBM disease and HLA-DQB1, -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk amino acid residues of anti-GBM disease.
Methods: This study included 44 Chinese patients with anti-GBM disease and 200 healthy controls. The clinical and pathological data of the patients were collected and analyzed. Typing of HLA-DQB1, -DQA1 and -DPB1 alleles were performed by bi-directional sequencing of exon 2 using the SeCoreTM Sequencing Kits.
Results: Compared with normal controls, the prevalence of HLA-DPB1*0401 was significantly lower in patients with anti-GBM disease (3/88 vs. 74/400, p = 4.4 x 10(-4), pc = 0.039). Comparing with normal controls, the combination of presence of DRB1*1501 and absence of DPB1*0401 was significantly prominent among anti-GBM patients (p = 2.0 x 10(-12), pc = 1.7 x 10(-10)).
Conclusions: HLA-DPB1*0401 might be a protective allele to anti-GBM disease in Chinese patients. The combined presence of DRB1*1501 and absence of DPB1*0401 might have an even higher risk to anti-GBM disease than HLA-DRB1*1501 alone.
|项目编号||30725034 ; 30972733|
|资助机构||National Science Foundation for Distinguished Young Scholars ; National Natural Science Fund|
|作者单位||1.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100034, Peoples R China|
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
|Luo, Huan,Chen, Min,Cui, Zhao,et al. The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients[J]. BMC NEPHROLOGY,2011,12.|
|APA||Luo, Huan.,Chen, Min.,Cui, Zhao.,Yang, Rui.,Xu, Peng-Cheng.,...&Zhao, Ming-Hui.(2011).The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients.BMC NEPHROLOGY,12.|
|MLA||Luo, Huan,et al."The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients".BMC NEPHROLOGY 12(2011).|