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The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients
Luo, Huan; Chen, Min1; Cui, Zhao; Yang, Rui; Xu, Peng-Cheng; Zhou, Xu-Jie; Zhao, Ming-Hui
关键词Anti-GBM disease HLA-DPB1*0401 Chinese
刊名BMC NEPHROLOGY
2011-05-13
DOI10.1186/1471-2369-12-21
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GOODPASTURES-DISEASE ; HLA ; SUSCEPTIBILITY ; AUTOANTIBODIES ; SEVERITY ; OUTCOMES ; LOCUS ; CELLS
英文摘要

Background: Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was strongly associated with anti-GBM disease in Chinese. However, the association of anti-GBM disease and other HLA class II genes, including HLA-DQB1, -DQA1, -DPB1 alleles, has rarely been investigated in Asian, especially Chinese patients. The present study further analyzed the association between anti-GBM disease and HLA-DQB1, -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk amino acid residues of anti-GBM disease.

Methods: This study included 44 Chinese patients with anti-GBM disease and 200 healthy controls. The clinical and pathological data of the patients were collected and analyzed. Typing of HLA-DQB1, -DQA1 and -DPB1 alleles were performed by bi-directional sequencing of exon 2 using the SeCoreTM Sequencing Kits.

Results: Compared with normal controls, the prevalence of HLA-DPB1*0401 was significantly lower in patients with anti-GBM disease (3/88 vs. 74/400, p = 4.4 x 10(-4), pc = 0.039). Comparing with normal controls, the combination of presence of DRB1*1501 and absence of DPB1*0401 was significantly prominent among anti-GBM patients (p = 2.0 x 10(-12), pc = 1.7 x 10(-10)).

Conclusions: HLA-DPB1*0401 might be a protective allele to anti-GBM disease in Chinese patients. The combined presence of DRB1*1501 and absence of DPB1*0401 might have an even higher risk to anti-GBM disease than HLA-DRB1*1501 alone.

语种英语
WOS记录号WOS:000304358600002
项目编号30725034 ; 30972733
资助机构National Science Foundation for Distinguished Young Scholars ; National Natural Science Fund
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59248
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Luo, Huan,Chen, Min,Cui, Zhao,et al. The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients[J]. BMC NEPHROLOGY,2011,12.
APA Luo, Huan.,Chen, Min.,Cui, Zhao.,Yang, Rui.,Xu, Peng-Cheng.,...&Zhao, Ming-Hui.(2011).The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients.BMC NEPHROLOGY,12.
MLA Luo, Huan,et al."The association of HLA-DQB1,-DQA1 and-DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients".BMC NEPHROLOGY 12(2011).
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