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Identification of the metabolites of baicalein in human plasma
Guo, Xiao-Yu1; Yang, Lin1,2; Chen, Ying1; Wang, Qi-Fang3; Sun, Qi-Shi3; Che, Yi-Xin1; Che, Qing-Ming1
关键词baicalein flavones metabolites human plasma LC-MS/MS HPLC-DAD
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2011
DOI10.1080/10286020.2011.599321
13期:9页:861-868
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]RATS ; GLUCURONIDE ; RADIX
英文摘要

The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.

语种英语
所属项目编号30225049
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000294802400012
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59256
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
2.China Acad Chinese Med Sci, Xiyuan Hosp, Ctr Cardiovasc Dis, Beijing 100091, Peoples R China
3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
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Guo, Xiao-Yu,Yang, Lin,Chen, Ying,et al. Identification of the metabolites of baicalein in human plasma[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(9):861-868.
APA Guo, Xiao-Yu.,Yang, Lin.,Chen, Ying.,Wang, Qi-Fang.,Sun, Qi-Shi.,...&Che, Qing-Ming.(2011).Identification of the metabolites of baicalein in human plasma.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(9),861-868.
MLA Guo, Xiao-Yu,et al."Identification of the metabolites of baicalein in human plasma".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.9(2011):861-868.
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