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学科主题: 药学
题名:
Identification of the metabolites of baicalein in human plasma
作者: Guo, Xiao-Yu1; Yang, Lin1,2; Chen, Ying1; Wang, Qi-Fang3; Sun, Qi-Shi3; Che, Yi-Xin1; Che, Qing-Ming1
关键词: baicalein ; flavones ; metabolites ; human plasma ; LC-MS/MS ; HPLC-DAD
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2011
DOI: 10.1080/10286020.2011.599321
卷: 13, 期:9, 页:861-868
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: RATS ; GLUCURONIDE ; RADIX
英文摘要:

The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.

语种: 英语
所属项目编号: 30225049
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000294802400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59256
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
2.China Acad Chinese Med Sci, Xiyuan Hosp, Ctr Cardiovasc Dis, Beijing 100091, Peoples R China
3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

Recommended Citation:
Guo, Xiao-Yu,Yang, Lin,Chen, Ying,et al. Identification of the metabolites of baicalein in human plasma[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(9):861-868.
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