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学科主题: 临床医学
题名:
New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma
作者: Liu, Fangfang1; Shen, Danhua1; Kang, Xiaoping2; Zhang, Chunfang3; Song, Qiujing1
刊名: JOURNAL OF CLINICAL PATHOLOGY
发表日期: 2015-11-01
DOI: 10.1136/jclinpath-2015-202978
卷: 68, 期:11, 页:913-916
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: COLORECTAL-CARCINOMA ; EXPRESSION ; PLACENTA ; GENE
英文摘要:

Aim To evaluate protein expression and clinical significance of PLAC1/CP1 antigen in primary gastric adenocarcinoma.

Methods Protein expression of PLAC1/CP1 was analysed by tissue chip and immunohistochemistry in surgical specimens obtained from 119 patients with gastric cancer. The data were analysed using SPSS V. 16.0 software applying the chi(2) test and Kaplan-Meier method.

Results The positive expression frequency of PLAC1/CP1 protein was 61.3% (73/119 patients). The overall survival of patients with PLAC1/CP1 protein-positive expression was significantly lower than that of patients with PLAC1/CP1 protein-negative expression (p<0.05). There was no significant relationship between PLAC1/CP1 expression and patient gender, age, tumour position, tumour size, differentiation, gross type, lymph node or TNM stage.

Conclusions PLAC1/CP1 protein is expressed in over half of cases of primary gastric cancer, and PLAC1/CP1 protein expression is inversely correlated with patient survival. The data indicate that PLAC1/CP1 provides a marker for identifying gastric cancers with poor prognosis, and suggest that PLAC1/CP1 may provide a useful target for immunotherapy.

语种: 英语
所属项目编号: 30801093 ; 2101000262 ; 7122195
项目资助者: National Science Foundation of China ; Beijing National Science Foundation
WOS记录号: WOS:000364997000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59257
Appears in Collections:北京大学第二临床医学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
2.Peking Univ, Dept Stat Off, Hlth Sci Ctr, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Fangfang,Shen, Danhua,Kang, Xiaoping,et al. New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma[J]. JOURNAL OF CLINICAL PATHOLOGY,2015,68(11):913-916.
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