IR@PKUHSC  > 北京大学药学院  > 化学生物学系
学科主题药学
Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells
Li, Jin-Xia1,2; Liu, Jing-Cheng1,2; Wang, Kui1,2; Yang, Xiao-Gai1
关键词Gadolinium-containing bioparticles Cell cycle progression Extracellular-signal-regulated protein kinase Phosphatidylinositol 3-kinase Nephrogenic systemic fibrosis
刊名JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
2010-05-01
DOI10.1007/s00775-010-0622-5
15期:4页:547-557
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]NEPHROGENIC SYSTEMIC FIBROSIS ; ENDOMYOCARDIAL FIBROSIS ; SIGNAL-TRANSDUCTION ; CONTRAST AGENTS ; RENAL-FAILURE ; IN-VITRO ; PROLIFERATION ; ERK ; GROWTH ; LANTHANIDES
英文摘要

In the present study, we demonstrated that gadolinium-containing particles formed in cell culture medium acted as a biologically active entity to mediate cell cycle progression in NIH3T3 cells. The particles were observed to accumulate at the cell surface by scanning electron microscopy. Energy-dispersive X-ray analysis was undertaken and confirmed that gadolinium was incorporated in the agglomerated particles. Moreover, the smaller gadolinium particles exhibited a stronger cell-cycle-promoting effect than the larger ones, but they shared the common signaling pathways. Both extracellular signal regulated kinase and phosphatidylinositol 3-kinase signaling pathways were activated by gadolinium-containing particles and may account for their proliferation-promoting effect on NIH3T3 cells. Furthermore, the study showed that the free gadolinium ion released from gadolinium-containing particles may be responsible for the proliferation effect. This study will be helpful to clarify the biological effect of the insoluble species formed from Gd(3+) as well as other multivalent metal ions under physiological conditions and will help to improve their medical applications.

语种英语
所属项目编号20637010
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000276660400007
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59261
Collection北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Jin-Xia,Liu, Jing-Cheng,Wang, Kui,et al. Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2010,15(4):547-557.
APA Li, Jin-Xia,Liu, Jing-Cheng,Wang, Kui,&Yang, Xiao-Gai.(2010).Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,15(4),547-557.
MLA Li, Jin-Xia,et al."Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 15.4(2010):547-557.
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