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学科主题: 药学
题名:
Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells
作者: Li, Jin-Xia1,2; Liu, Jing-Cheng1,2; Wang, Kui1,2; Yang, Xiao-Gai1
关键词: Gadolinium-containing bioparticles ; Cell cycle progression ; Extracellular-signal-regulated protein kinase ; Phosphatidylinositol 3-kinase ; Nephrogenic systemic fibrosis
刊名: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
发表日期: 2010-05-01
DOI: 10.1007/s00775-010-0622-5
卷: 15, 期:4, 页:547-557
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: NEPHROGENIC SYSTEMIC FIBROSIS ; ENDOMYOCARDIAL FIBROSIS ; SIGNAL-TRANSDUCTION ; CONTRAST AGENTS ; RENAL-FAILURE ; IN-VITRO ; PROLIFERATION ; ERK ; GROWTH ; LANTHANIDES
英文摘要:

In the present study, we demonstrated that gadolinium-containing particles formed in cell culture medium acted as a biologically active entity to mediate cell cycle progression in NIH3T3 cells. The particles were observed to accumulate at the cell surface by scanning electron microscopy. Energy-dispersive X-ray analysis was undertaken and confirmed that gadolinium was incorporated in the agglomerated particles. Moreover, the smaller gadolinium particles exhibited a stronger cell-cycle-promoting effect than the larger ones, but they shared the common signaling pathways. Both extracellular signal regulated kinase and phosphatidylinositol 3-kinase signaling pathways were activated by gadolinium-containing particles and may account for their proliferation-promoting effect on NIH3T3 cells. Furthermore, the study showed that the free gadolinium ion released from gadolinium-containing particles may be responsible for the proliferation effect. This study will be helpful to clarify the biological effect of the insoluble species formed from Gd(3+) as well as other multivalent metal ions under physiological conditions and will help to improve their medical applications.

语种: 英语
所属项目编号: 20637010
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000276660400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59261
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Li, Jin-Xia,Liu, Jing-Cheng,Wang, Kui,et al. Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2010,15(4):547-557.
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