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学科主题临床医学
Helicobacter Pylori and Gastric Cancer: Clinical Aspects
Song, Zhi-Qiang; Zhou, Li-Ya
关键词Clinical Eradication Gastric Cancer Helicobacter pylori Screening
刊名CHINESE MEDICAL JOURNAL
2015-11-20
DOI10.4103/0366-6999.169107
128期:22页:3101-3105
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Science and Technology Pillar Program during the Twelfth Five-year Plan Period ; Capital Health Research and Development of Special ; Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases in Beijing ; National Science and Technology Pillar Program during the Twelfth Five-year Plan Period ; Capital Health Research and Development of Special ; Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases in Beijing
研究领域[WOS]General & Internal Medicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; ENDOSCOPIC RESECTION ; COST-EFFECTIVENESS ; ERADICATION ; ELIMINATION ; PREVENTION ; MANAGEMENT ; RESISTANCE ; MORTALITY ; INFECTION
英文摘要

Objective: Although Helicobacter pylori (H. pylori) is considered as the main etiological factor for gastric cancer, the strategy of screening and treating the oncogenic bacterium is still controversial. The objective was to evaluate the status and progress of the cognition about the relationship between H. pylori infection and gastric cancer from a clinical aspect.

Data Sources: The data used in this review were mainly from the PubMed articles published in English from 1984 to 2015.

Study Selection: Clinical research articles were selected mainly according to their level of relevance to this topic.

Results: Gastric cancer is the fifth most common malignancy and the third leading cause of cancer deaths worldwide. The main etiological factor for gastric cancer is H. pylori infection. About 74.7-89.0% gastric cancer was related to H. pylori infection. Up to date, some regional gastric cancer prevention programs including the detection and treatment of H. pylori infection are under way. Current data obtained from the randomized controlled trials suggest that population-based H. pylori screening and treatment is feasible and cost-effective in preventing gastric cancer; however, a population-based H. pylori eradication campaign would potentially lead to bacterial resistance to the corresponding antibiotics, as well as a negative impact on the normal flora.

Conclusions: The important questions of feasibility, program costs, appropriate target groups for intervention, and the potential harm of mass therapy with antibiotics must first be answered before implementing any large-scale program.

语种英语
所属项目编号2012BAI06B02 ; 2011-4032-02 ; BZ0371
资助者National Science and Technology Pillar Program during the Twelfth Five-year Plan Period ; Capital Health Research and Development of Special ; Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases in Beijing ; National Science and Technology Pillar Program during the Twelfth Five-year Plan Period ; Capital Health Research and Development of Special ; Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases in Beijing
WOS记录号WOS:000365773400019
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59268
专题北京大学第三临床医学院_消化科
作者单位Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Song, Zhi-Qiang,Zhou, Li-Ya. Helicobacter Pylori and Gastric Cancer: Clinical Aspects[J]. CHINESE MEDICAL JOURNAL,2015,128(22):3101-3105.
APA Song, Zhi-Qiang,&Zhou, Li-Ya.(2015).Helicobacter Pylori and Gastric Cancer: Clinical Aspects.CHINESE MEDICAL JOURNAL,128(22),3101-3105.
MLA Song, Zhi-Qiang,et al."Helicobacter Pylori and Gastric Cancer: Clinical Aspects".CHINESE MEDICAL JOURNAL 128.22(2015):3101-3105.
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