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学科主题: 临床医学
题名:
Clinical antiangiogenic effect of recombinant adenovirus-p53 combined with hyperthermia for advanced cancer
作者: Li, Xiaofan; Xiao, Shaowen; Li, Yongheng; Zhang, Shanwen
关键词: Vascular epithelial growth factor (VEGF) ; recombinant adenovirus-p53 (rAd-p53) ; advanced cancer ; hyperthermia ; radiotherapy
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2013-12-01
DOI: 10.3978/j.issn.1000-9604.2013.12.05
卷: 25, 期:6, 页:749-755
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: P53 GENE-TRANSFER ; WILD-TYPE P53 ; SQUAMOUS-CELL CARCINOMA ; TUMOR RESPONSE ; LUNG-CANCER ; THERAPY ; CT ; ANGIOGENESIS ; INHIBITION ; HEAD
英文摘要:

Objective: To assess the safety and clinical antiangiogenic effect of recombinant adenovirus-p53 (rAd-p53) combined with hyperthermia plus or not plus radiotherapy in advanced cancer.

Methods: Expression of Vascular epithelial growth factor (VEGF) after intratumoral injection of rAd-p53 was assayed by immunohistochemistry (IHC) imaging. Forty-four patients with advanced cancer were enrolled into this clinical study. The patients were intratumorally injected with rAd-p53 (Gendicine) at a dose of 1 x 10(12) vp once a week, with a total of 4-54 (mean 7.7) times. Total of 4-29 (mean 8.5) times of hyperthermia was given to the patients. Among the 44 patients, 30 patients were concurrently added with radiotherapy of a total dose 30-76 Gy/15-38 f/3-8 w (mean 58 Gy).

Results: Before and after intratumoral infection of rAd-p53, the VEGF IHC positive cell scores were 2.80 and 1.50, respectively (P.0.031). The treatment of rAd-p53 combined with hyperthermia plus or not plus radiotherapy in advanced cancer achieved CR rate of 13.60% (6/44), and PR rate of 29.6% (13/44), and thus the effective rate was 43.2%. In addition to 6 patients with CR, 19 patients (19/38, 50.0%) had low density area (LDA) of more than 50% area on CT image within tumor indicating tumor tissue necrosis.

Conclusions: Our data indicate that rAd-p53 inhibits VEGF expression and angiogenesis, and promotes tumor necrosis and shrinkage induced by hyperthermia plus or not plus radiotherapy in advanced cancer.

语种: 英语
WOS记录号: WOS:000329477800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59275
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Canc Hosp & Inst, Dept Radiotherapy, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Li, Xiaofan,Xiao, Shaowen,Li, Yongheng,et al. Clinical antiangiogenic effect of recombinant adenovirus-p53 combined with hyperthermia for advanced cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(6):749-755.
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