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学科主题: 临床医学
题名:
Intervention study of the association of antibiotic utilization measures with control of extended-spectrum beta-lactamase (ESBL)-producing bacteria
作者: Wen, Zhongguang1; Wei, Xiaoyang1; Xiao, Yonghong2; Xue, Feng2; Hao, Fenglan2; Zhu, Yan2; Ma, Nan1; Xiao, Yan1; Wang, Haiyan1
关键词: Cephalosporins ; Extended spectrum beta-lactamases ; Piperacillin-tazobactam ; Acquisition rate ; Infection rate
刊名: MICROBES AND INFECTION
发表日期: 2010-09-01
DOI: 10.1016/j.micinf.2010.04.015
卷: 12, 期:10, 页:710-715
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]: Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]: INTENSIVE-CARE-UNIT ; KLEBSIELLA-PNEUMONIAE ; ESCHERICHIA-COLI ; RESISTANCE ; CEPHALOSPORINS ; PATTERNS ; IMPACT ; POLICY
英文摘要:

We investigated the effects of replacing third-/fourth-generation cephalosporins with piperacillin tazobactam on the rate of acquisition of extended spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli by patients hospitalized in a Department of Respiratory Medicine.

This 9-month, prospective, non-controlled, intervention study comprised two phases: a 3-month pre-intervention phase (Phase I) and a 6-month intervention phase (Phase II), during which the use of third-/forth-generation cephalosporins was restricted and replaced by piperacillin tazobactam. Rectal swabs were obtained within 24 h after admission (baseline screening), weekly, and 48 h before discharge during Phase I and the last 3 months of Phase II (Phase lib). Swabs were tested for E. coli and K. pneumoniae, and extended spectrum beta-lactamase production was detected with the double disc test.

Use of third/fourth-generation cephalosporins decreased by 63.0% and 100%, respectively; while the use of piperacillin tazobactam increased by 28-fold. The rate of acquisition of extended spectrum beta-lactamase-producing E. coli and K. pneumoniae together in rectal swab specimens decreased in Phase IIb as compared with Phase I (19.5% vs 29.5%). Few rectal swab specimens were positive for extended spectrum beta-lactamases-producing K. pneumoniae, and no substantial decrease in the rate of its acquisition was observed. (C) 2010 Elsevier Masson SAS. All rights reserved.

语种: 英语
项目资助者: Wyeth Pharmaceuticals
WOS记录号: WOS:000282906000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59277
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Beijing 100048, Peoples R China
2.Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing 100191, Peoples R China

Recommended Citation:
Wen, Zhongguang,Wei, Xiaoyang,Xiao, Yonghong,et al. Intervention study of the association of antibiotic utilization measures with control of extended-spectrum beta-lactamase (ESBL)-producing bacteria[J]. MICROBES AND INFECTION,2010,12(10):710-715.
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