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学科主题: 临床医学
题名:
The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rH alpha 3(IV)NC1 is associated with disease severity
作者: Zhao, Juan; Yan, Yu; Cui, Zhao; Yang, Rui; Zhao, Ming-Hui
关键词: Anti-GBM disease ; Anti-GBM autoantibody ; IgG subclass ; Renal function
刊名: HUMAN IMMUNOLOGY
发表日期: 2009-06-01
DOI: 10.1016/j.humimm.2009.04.004
卷: 70, 期:6, 页:425-429
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: GLOMERULAR-BASEMENT-MEMBRANE ; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS ; IGG SUBCLASS ; GOODPASTURE-DISEASE ; COLLAGEN-IV ; RATS ; RESTRICTION ; EXPRESSION ; ANTIBODIES ; NEPHRITIS
英文摘要:

The current Study aimed to investigate the association between antiglomerular basement membrane (GBM) immunoglobulin (Ig) G subclass distribution and the severity of anti-GBM nephritis in human beings. Natural anti-GBM IgG affinity purified from five healthy donors was defined as group A. A total of 73 Chinese patients with anti-GBM disease were divided into three groups (groups B, C, and D) according to their serum creatinine (Scr) on diagnosis. Anti-GBM IgG Subclasses were detected by enzyme-linked immunosorbent assay using recombinant human noncollagenous domain 1 of type IV collagen of the alpha 3 chain [rH alpha 3(IV)NC1]. Anti-GBM IgG I Could not be detected in group A (0%), appeared in group B (7.7%), was significantly higher in group C (69%), and was the highest in group D (93.5%). The frequency of IgG3 ill groups C and D was significantly higher than that in groups A and B. In group A, anti-GBM IgG subclass distribution was restricted to IgG4 and IgG2; in group B, IgG2 and IgG4 remained the Major Subclasses with detectable IgG I : in group C, IgG I became predominant and IgG3 was detectable; ill group D, four IgG Subclasses Could be detected. Ill conclusion, anti-GBM autoantibody IgG subclass distribution was associated with disease severity. IgG I and IgG3 may play a major role in the initiation and progression of the disease. (C) 2009 Published by Elsevier Inc. oil behalf of American Society for Histocompatibility and Immunogenetics.

语种: 英语
所属项目编号: 30700752 ; 30570852
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000266806900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59279
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Key Lab Renal Dis, Minist Hlth China, Div Renal,Dept Med,Inst Nephrol,Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, Juan,Yan, Yu,Cui, Zhao,et al. The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rH alpha 3(IV)NC1 is associated with disease severity[J]. HUMAN IMMUNOLOGY,2009,70(6):425-429.
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