IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rH alpha 3(IV)NC1 is associated with disease severity
Zhao, Juan; Yan, Yu; Cui, Zhao; Yang, Rui; Zhao, Ming-Hui
关键词Anti-GBM disease Anti-GBM autoantibody IgG subclass Renal function
刊名HUMAN IMMUNOLOGY
2009-06-01
DOI10.1016/j.humimm.2009.04.004
70期:6页:425-429
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]GLOMERULAR-BASEMENT-MEMBRANE ; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS ; IGG SUBCLASS ; GOODPASTURE-DISEASE ; COLLAGEN-IV ; RATS ; RESTRICTION ; EXPRESSION ; ANTIBODIES ; NEPHRITIS
英文摘要

The current Study aimed to investigate the association between antiglomerular basement membrane (GBM) immunoglobulin (Ig) G subclass distribution and the severity of anti-GBM nephritis in human beings. Natural anti-GBM IgG affinity purified from five healthy donors was defined as group A. A total of 73 Chinese patients with anti-GBM disease were divided into three groups (groups B, C, and D) according to their serum creatinine (Scr) on diagnosis. Anti-GBM IgG Subclasses were detected by enzyme-linked immunosorbent assay using recombinant human noncollagenous domain 1 of type IV collagen of the alpha 3 chain [rH alpha 3(IV)NC1]. Anti-GBM IgG I Could not be detected in group A (0%), appeared in group B (7.7%), was significantly higher in group C (69%), and was the highest in group D (93.5%). The frequency of IgG3 ill groups C and D was significantly higher than that in groups A and B. In group A, anti-GBM IgG subclass distribution was restricted to IgG4 and IgG2; in group B, IgG2 and IgG4 remained the Major Subclasses with detectable IgG I : in group C, IgG I became predominant and IgG3 was detectable; ill group D, four IgG Subclasses Could be detected. Ill conclusion, anti-GBM autoantibody IgG subclass distribution was associated with disease severity. IgG I and IgG3 may play a major role in the initiation and progression of the disease. (C) 2009 Published by Elsevier Inc. oil behalf of American Society for Histocompatibility and Immunogenetics.

语种英语
WOS记录号WOS:000266806900009
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59279
专题北京大学第一临床医学院_肾脏内科
北京大学第二临床医学院_肾内科
北京大学临床肿瘤学院_药剂科
作者单位Peking Univ, Key Lab Renal Dis, Minist Hlth China, Div Renal,Dept Med,Inst Nephrol,Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Juan,Yan, Yu,Cui, Zhao,et al. The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rH alpha 3(IV)NC1 is associated with disease severity[J]. HUMAN IMMUNOLOGY,2009,70(6):425-429.
APA Zhao, Juan,Yan, Yu,Cui, Zhao,Yang, Rui,&Zhao, Ming-Hui.(2009).The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rH alpha 3(IV)NC1 is associated with disease severity.HUMAN IMMUNOLOGY,70(6),425-429.
MLA Zhao, Juan,et al."The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rH alpha 3(IV)NC1 is associated with disease severity".HUMAN IMMUNOLOGY 70.6(2009):425-429.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Juan]的文章
[Yan, Yu]的文章
[Cui, Zhao]的文章
百度学术
百度学术中相似的文章
[Zhao, Juan]的文章
[Yan, Yu]的文章
[Cui, Zhao]的文章
必应学术
必应学术中相似的文章
[Zhao, Juan]的文章
[Yan, Yu]的文章
[Cui, Zhao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。