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学科主题临床医学
Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone
Qu, Huayi; Guo, Wei; Yang, Rongli; Li, Dasen; Tang, Shun; Yang, Yi; Dong, Sen; Zang, Jie
关键词Intercalary bone defect Bone tumor Devitalization Reconstruction
刊名WORLD JOURNAL OF SURGICAL ONCOLOGY
2015-09-24
DOI10.1186/s12957-015-0694-3
13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
资助者NHFPC special fund for health scientific research in the public welfare ; NHFPC special fund for health scientific research in the public welfare
研究领域[WOS]Oncology ; Surgery
关键词[WOS]INTERCALARY RECONSTRUCTION ; PROTEIN STABILITY ; ALLOGRAFT ; AUTOGRAFT ; SYSTEM
英文摘要

Background: The reconstruction of an intercalary bone defect after a tumor resection of a long bone remains a challenge to orthopedic surgeons. Though several methods have been adopted to enhance the union of long segmental allografts or retrieved segmental autografts to the host bones, still more progresses are required to achieve a better union rate. Several methods have been adopted to devitalize tumor bone for recycling usage, and the results varied. We describe our experiences of using devitalized tumor-bearing bones for the repairing of segmental defects after tumor resection.

Methods: Twenty-seven eligible patients treated from February 2004 to May 2012 were included. The segmental tumor bone (mean length, 14 cm) was resected, and then devitalized in 20 % sterile saline at 65 degrees C for 30 min after the tumor tissue was removed. The devitalized bone was implanted back into the defect by using nails or plates.

Results: Complete healing of 50 osteotomy ends was achieved at a median time of 11 months (interquartile range (IQR) 9-13 months). Major complications included bone nonunion in four bone junctions (7.4 %), devitalized bone fracture in one patient (3.7 %), deep infection in three patients (11.1 %), and fixation failure in two patients (7.4 %). The bone union rates at 1 and 2 years were 74.1 and 92.6 %, respectively. The average functional score according to the Musculoskeletal Tumor Society (MSTS) 93 scoring system was 93 % (IQR 80-96.7 %).

Conclusions: Incubation in 20 % sterile saline at 65 degrees C for 30 min is an effective method of devitalization of tumor-bearing bone. The retrieved bone graft may provide as a less expensive alternative for limb salvage. The structural bone and the preserved osteoinductivity of protein may improve bone union.

语种英语
所属项目编号20140216
资助者NHFPC special fund for health scientific research in the public welfare ; NHFPC special fund for health scientific research in the public welfare
WOS记录号WOS:000361648000001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59280
专题北京大学第二临床医学院_骨肿瘤科
作者单位Peking Univ, Musculoskeletal Tumor Ctr, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Qu, Huayi,Guo, Wei,Yang, Rongli,et al. Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2015,13.
APA Qu, Huayi.,Guo, Wei.,Yang, Rongli.,Li, Dasen.,Tang, Shun.,...&Zang, Jie.(2015).Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone.WORLD JOURNAL OF SURGICAL ONCOLOGY,13.
MLA Qu, Huayi,et al."Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone".WORLD JOURNAL OF SURGICAL ONCOLOGY 13(2015).
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