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IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone
作者: Qu, Huayi; Guo, Wei; Yang, Rongli; Li, Dasen; Tang, Shun; Yang, Yi; Dong, Sen; Zang, Jie
关键词: Intercalary bone defect ; Bone tumor ; Devitalization ; Reconstruction
刊名: WORLD JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2015-09-24
DOI: 10.1186/s12957-015-0694-3
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: INTERCALARY RECONSTRUCTION ; PROTEIN STABILITY ; ALLOGRAFT ; AUTOGRAFT ; SYSTEM
英文摘要:

Background: The reconstruction of an intercalary bone defect after a tumor resection of a long bone remains a challenge to orthopedic surgeons. Though several methods have been adopted to enhance the union of long segmental allografts or retrieved segmental autografts to the host bones, still more progresses are required to achieve a better union rate. Several methods have been adopted to devitalize tumor bone for recycling usage, and the results varied. We describe our experiences of using devitalized tumor-bearing bones for the repairing of segmental defects after tumor resection.

Methods: Twenty-seven eligible patients treated from February 2004 to May 2012 were included. The segmental tumor bone (mean length, 14 cm) was resected, and then devitalized in 20 % sterile saline at 65 degrees C for 30 min after the tumor tissue was removed. The devitalized bone was implanted back into the defect by using nails or plates.

Results: Complete healing of 50 osteotomy ends was achieved at a median time of 11 months (interquartile range (IQR) 9-13 months). Major complications included bone nonunion in four bone junctions (7.4 %), devitalized bone fracture in one patient (3.7 %), deep infection in three patients (11.1 %), and fixation failure in two patients (7.4 %). The bone union rates at 1 and 2 years were 74.1 and 92.6 %, respectively. The average functional score according to the Musculoskeletal Tumor Society (MSTS) 93 scoring system was 93 % (IQR 80-96.7 %).

Conclusions: Incubation in 20 % sterile saline at 65 degrees C for 30 min is an effective method of devitalization of tumor-bearing bone. The retrieved bone graft may provide as a less expensive alternative for limb salvage. The structural bone and the preserved osteoinductivity of protein may improve bone union.

语种: 英语
所属项目编号: 20140216
项目资助者: NHFPC special fund for health scientific research in the public welfare
WOS记录号: WOS:000361648000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59280
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: Peking Univ, Musculoskeletal Tumor Ctr, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Qu, Huayi,Guo, Wei,Yang, Rongli,et al. Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2015,13.
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