IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
Cao, Jie1; Zhou, Jing2; Gao, Yan1; Gu, Liankun2; Meng, Huanxin1; Liu, Hongwei1; Deng, Dajun2
刊名CLINICAL CANCER RESEARCH
2009-08-15
DOI10.1158/1078-0432.CCR-09-0580
15期:16页:5178-5183
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TUMOR-SUPPRESSOR GENE ; PROMOTER METHYLATION ; DNA METHYLATION ; HUMAN CANCERS ; NECK-CANCER ; INACTIVATION ; FREQUENCY ; RISK ; HEAD ; TRANSFORMATION
英文摘要

Purpose: Inactivation of p16 gene by CpG methylation is a frequent event in oral epithelial dysplasia. To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospective cohort study.

Experimental Design: One hundred one patients with histologically confirmed mild or moderate oral epithelial dysplasia were included in the present cohort study. p16 Methylation status of the oral epithelial dysplasia lesions from 93 cases was obtained by methylation-specific PCR. Progression of the oral epithelial dysplasia lesions was examined in 78 cases histologically during a 45.8 months follow-up period. The association between p16 methylation and progression of oral epithelial dysplasia was analyzed.

Results: Of the 93 enrolled cases, 15 cases were lost during the follow-up because of changes of contact information, with a compliance of 83.9%. p16 Methylation was detectable in oral epithelial dysplasia lesions from 32 (41.0%) of 78 enrolled patients. Oral epithelial dysplasia-related squamous cell carcinomas were observed in 22 patients (28.2%) during the follow-up. Rate of progression to oral cancer in patients with the p16-methylated oral epithelial dysplasia was significantly higher than that with the p16-unmethylated oral epithelial dysplasia (43.8% versus 17.4%; adjusted odds ratio, 3.7; P = 0.013), especially for patients at the baseline age of 60 years (adjusted odds ratio, 12.0; P = 0.003) and patients with moderate oral epithelial dysplasia (adjusted odds ratio, 15.6; P = 0.022). The overall sensitivity and specificity of prediction of malignant transformation of oral epithelial dysplasia by p16 methylation were 63.6% and 67.9%, respectively.

Conclusion: p16 Methylation was correlated with malignant transformation of oral epithelial dysplasia and is a potential biomarker for prediction of prognosis of mild or moderate oral epithelial dysplasia. (Clin Cancer Res 2009;15(16):5178-83)

语种英语
WOS记录号WOS:000269024900020
项目编号2005CB 522403 ; 434
资助机构National Basic Research Program of China ; Capital Program for Development of Health Sciences
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59286
专题北京大学临床肿瘤学院
北京大学口腔医学院_牙周科
北京大学口腔医学院_口腔黏膜科
北京大学临床肿瘤学院_病因学研究室
作者单位1.Peking Univ, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp Inst, Minist Educ,Dept Aetiol,Sch Oncol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Cao, Jie,Zhou, Jing,Gao, Yan,et al. Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study[J]. CLINICAL CANCER RESEARCH,2009,15(16):5178-5183.
APA Cao, Jie.,Zhou, Jing.,Gao, Yan.,Gu, Liankun.,Meng, Huanxin.,...&Deng, Dajun.(2009).Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study.CLINICAL CANCER RESEARCH,15(16),5178-5183.
MLA Cao, Jie,et al."Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study".CLINICAL CANCER RESEARCH 15.16(2009):5178-5183.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cao, Jie]的文章
[Zhou, Jing]的文章
[Gao, Yan]的文章
百度学术
百度学术中相似的文章
[Cao, Jie]的文章
[Zhou, Jing]的文章
[Gao, Yan]的文章
必应学术
必应学术中相似的文章
[Cao, Jie]的文章
[Zhou, Jing]的文章
[Gao, Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。