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学科主题: 精神卫生
题名:
A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking
作者: Luo, Yi-xiao1,2; Xue, Yan-xue2; Liu, Jian-feng1,2; Shi, Hai-shui3; Jian, Min1,2; Han, Ying1,2; Zhu, Wei-li2; Bao, Yan-ping2; Wu, Ping2; Ding, Zeng-bo2; Shen, Hao-wei2; Shi, Jie2; Shaham, Yavin4; Lu, Lin1,2,5
刊名: NATURE COMMUNICATIONS
发表日期: 2015-07-01
DOI: 10.1038/ncomms8675
卷: 6
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: NUCLEUS-ACCUMBENS CORE ; CONDITIONED PLACE PREFERENCE ; AMPA RECEPTOR ENDOCYTOSIS ; LONG-TERM DEPRESSION ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; FEAR MEMORY ; BEHAVIORAL SENSITIZATION ; INDUCED REINSTATEMENT ; SIGNALING PATHWAY
英文摘要:

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.

语种: 英语
所属项目编号: 2015CB856400 ; 2015CB553503 ; 31230033 ; 81221002 ; 91432303
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China ; NIDA
WOS记录号: WOS:000358858100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59291
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Key Lab Mental Hlth, Inst Mental Hlth, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Drug Dependence Res, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China
4.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA
5.Peking Univ, McGovern Inst Brain Res, Peking Tsinghua Ctr Life Sci, PKU IDG, Beijing 100871, Peoples R China

Recommended Citation:
Luo, Yi-xiao,Xue, Yan-xue,Liu, Jian-feng,et al. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking[J]. NATURE COMMUNICATIONS,2015,6.
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