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A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking
Luo, Yi-xiao1,2; Xue, Yan-xue2; Liu, Jian-feng1,2; Shi, Hai-shui3; Jian, Min1,2; Han, Ying1,2; Zhu, Wei-li2; Bao, Yan-ping2; Wu, Ping2; Ding, Zeng-bo2; Shen, Hao-wei2; Shi, Jie2; Shaham, Yavin4; Lu, Lin1,2,5
刊名NATURE COMMUNICATIONS
2015-07-01
DOI10.1038/ncomms8675
6
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NUCLEUS-ACCUMBENS CORE ; CONDITIONED PLACE PREFERENCE ; AMPA RECEPTOR ENDOCYTOSIS ; LONG-TERM DEPRESSION ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; FEAR MEMORY ; BEHAVIORAL SENSITIZATION ; INDUCED REINSTATEMENT ; SIGNALING PATHWAY
英文摘要

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.

语种英语
WOS记录号WOS:000358858100019
项目编号2015CB856400 ; 2015CB553503 ; 31230033 ; 81221002 ; 91432303
资助机构National Basic Research Program of China ; Natural Science Foundation of China ; NIDA
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59291
专题北京大学精神卫生研究所
北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Key Lab Mental Hlth, Inst Mental Hlth, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Drug Dependence Res, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China
4.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA
5.Peking Univ, McGovern Inst Brain Res, Peking Tsinghua Ctr Life Sci, PKU IDG, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Luo, Yi-xiao,Xue, Yan-xue,Liu, Jian-feng,et al. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking[J]. NATURE COMMUNICATIONS,2015,6.
APA Luo, Yi-xiao.,Xue, Yan-xue.,Liu, Jian-feng.,Shi, Hai-shui.,Jian, Min.,...&Lu, Lin.(2015).A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.NATURE COMMUNICATIONS,6.
MLA Luo, Yi-xiao,et al."A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking".NATURE COMMUNICATIONS 6(2015).
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