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学科主题: 精神卫生
题名:
Association Analyses of MAOA in Chinese Han Subjects with Attention-Deficit/Hyperactivity Disorder: Family-Based Association Test, Case-Control Study, and Quantitative Traits of Impulsivity
作者: Liu, Lu1,2; Guan, Li-Li1,2; Chen, Yun1,2; Ji, Ning1,2; Li, Hai-Mei1,2; Li, Ze-Hua1,2; Qian, Qiu-Jin1,2; Yang, Li1,2; Glatt, Stephen J.3,4; Faraone, Stephen V.3,4; Wang, Yu-Feng1,2
关键词: MAOA ; ADHD ; subtype ; impulsivity ; endophenotype
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2011-09-01
DOI: 10.1002/ajmg.b.31217
卷: 156B, 期:6, 页:737-748
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: DEFICIT-HYPERACTIVITY-DISORDER ; MONOAMINE-OXIDASE-A ; BEHAVIOR RATING INVENTORY ; OPPOSITIONAL DEFIANT DISORDER ; RECEPTOR GENE ADRA2A ; DSM-IV SUBTYPES ; EXECUTIVE FUNCTION ; PREFERENTIAL TRANSMISSION ; FUNCTIONAL POLYMORPHISM ; INHIBITORY CONTROL
英文摘要:

Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Genetic studies have found an association between MAOA and attention-deficit/hyperactivity disorder (ADHD), especially impulsivity. However, there has been inconsistency among studies which may be due to the complexity and heterogeneity of ADHD, including its sexual dimorphism and the presence of several subtypes. We conducted transmission disequilibrium tests (TDTs) in 1,253 trios and found no association between five single nucleotide polymorphisms (SNPs) of MAOA with ADHD in general or in the predominantly inattentive (ADHD-I) or combined types (ADHD-C), but with the predominantly hyperactive/impulsivity type (ADHD-HI). The association with MAOA was restricted to males, especially males with ADHD-HI. Logistic regression analyses of data from 1,824 cases and 957 controls did not indicate any association. We used analysis of covariance to analyze the association between MAOA genotype with the "inhibit′′ factor of the Behavior Rating Inventory of Executive Function (BRIEF) in 640 probands and performance on the Stroop test in 810 probands. Probands homozygous for risk alleles found in the TDT test had higher "inhibit′′ scores on the BRIEF scale which represents more severe impulsivity; this results also was restricted to males. No association was found with Stroop test performance. In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender. (C) 2011 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 200802073 ; 2007BAI17B03 ; 81071109 ; 30800302
项目资助者: Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; China Scholarship Council
WOS记录号: WOS:000294228600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59292
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY USA
4.SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY USA

Recommended Citation:
Liu, Lu,Guan, Li-Li,Chen, Yun,et al. Association Analyses of MAOA in Chinese Han Subjects with Attention-Deficit/Hyperactivity Disorder: Family-Based Association Test, Case-Control Study, and Quantitative Traits of Impulsivity[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2011,156B(6):737-748.
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