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Association Analyses of MAOA in Chinese Han Subjects with Attention-Deficit/Hyperactivity Disorder: Family-Based Association Test, Case-Control Study, and Quantitative Traits of Impulsivity
Liu, Lu1,2; Guan, Li-Li1,2; Chen, Yun1,2; Ji, Ning1,2; Li, Hai-Mei1,2; Li, Ze-Hua1,2; Qian, Qiu-Jin1,2; Yang, Li1,2; Glatt, Stephen J.3,4; Faraone, Stephen V.3,4; Wang, Yu-Feng1,2
关键词MAOA ADHD subtype impulsivity endophenotype
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2011-09-01
DOI10.1002/ajmg.b.31217
156B期:6页:737-748
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT-HYPERACTIVITY-DISORDER ; MONOAMINE-OXIDASE-A ; BEHAVIOR RATING INVENTORY ; OPPOSITIONAL DEFIANT DISORDER ; RECEPTOR GENE ADRA2A ; DSM-IV SUBTYPES ; EXECUTIVE FUNCTION ; PREFERENTIAL TRANSMISSION ; FUNCTIONAL POLYMORPHISM ; INHIBITORY CONTROL
英文摘要

Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Genetic studies have found an association between MAOA and attention-deficit/hyperactivity disorder (ADHD), especially impulsivity. However, there has been inconsistency among studies which may be due to the complexity and heterogeneity of ADHD, including its sexual dimorphism and the presence of several subtypes. We conducted transmission disequilibrium tests (TDTs) in 1,253 trios and found no association between five single nucleotide polymorphisms (SNPs) of MAOA with ADHD in general or in the predominantly inattentive (ADHD-I) or combined types (ADHD-C), but with the predominantly hyperactive/impulsivity type (ADHD-HI). The association with MAOA was restricted to males, especially males with ADHD-HI. Logistic regression analyses of data from 1,824 cases and 957 controls did not indicate any association. We used analysis of covariance to analyze the association between MAOA genotype with the "inhibit′′ factor of the Behavior Rating Inventory of Executive Function (BRIEF) in 640 probands and performance on the Stroop test in 810 probands. Probands homozygous for risk alleles found in the TDT test had higher "inhibit′′ scores on the BRIEF scale which represents more severe impulsivity; this results also was restricted to males. No association was found with Stroop test performance. In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender. (C) 2011 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000294228600012
项目编号200802073 ; 2007BAI17B03 ; 81071109 ; 30800302
资助机构Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; China Scholarship Council
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59292
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY USA
4.SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY USA
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Liu, Lu,Guan, Li-Li,Chen, Yun,et al. Association Analyses of MAOA in Chinese Han Subjects with Attention-Deficit/Hyperactivity Disorder: Family-Based Association Test, Case-Control Study, and Quantitative Traits of Impulsivity[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2011,156B(6):737-748.
APA Liu, Lu.,Guan, Li-Li.,Chen, Yun.,Ji, Ning.,Li, Hai-Mei.,...&Wang, Yu-Feng.(2011).Association Analyses of MAOA in Chinese Han Subjects with Attention-Deficit/Hyperactivity Disorder: Family-Based Association Test, Case-Control Study, and Quantitative Traits of Impulsivity.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,156B(6),737-748.
MLA Liu, Lu,et al."Association Analyses of MAOA in Chinese Han Subjects with Attention-Deficit/Hyperactivity Disorder: Family-Based Association Test, Case-Control Study, and Quantitative Traits of Impulsivity".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 156B.6(2011):737-748.
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